Blephamide S.O.P.

The typical dosage of Blephamide S.O.P. is:

• Application: A small amount of the ointment (approximately 1/2 inch) is applied to the inside of the lower eyelid (conjunctival sac) one to three times daily, depending on the severity of the condition and the response to treatment.

Blephamide S.O.P. is contraindicated in patients with:

• Known hypersensitivity to sulfacetamide sodium, prednisolone acetate, or any other component of the formulation.
• Viral diseases of the cornea and conjunctiva, such as herpes simplex keratitis, vaccinia, or varicella.
• Fungal diseases of ocular structures, as corticosteroids can exacerbate these conditions.
• Mycobacterial eye infections (e.g., tuberculosis of the eye).

Patients using Blephamide S.O.P. should be advised to:

• Follow the prescribed dosage and duration of use carefully. Do not use the ointment longer than recommended by your healthcare provider to avoid potential side effects.
• Avoid wearing contact lenses during treatment, as they can exacerbate irritation and may become contaminated by the ointment.
• Report any signs of worsening symptoms, such as increased redness, pain, or swelling, to your healthcare provider, as these may indicate a worsening infection or an adverse reaction.
• Be aware of possible side effects, such as blurred vision immediately after application, and avoid driving or operating heavy machinery until vision clears.
• Store the ointment at room temperature and keep the cap tightly closed when not in use to prevent contamination.

• Temporary blurred vision after application.
• Mild stinging, burning, or itching of the eye.
• Increased sensitivity to light.
• Tearing or watery eyes.

• Increased Intraocular Pressure (IOP): Prolonged use of corticosteroids can lead to increased IOP, which may result in glaucoma.
• Cataract Formation: Long-term use of corticosteroids in the eye can increase the risk of developing cataracts.
• Delayed Wound Healing: Corticosteroids can delay the healing of corneal injuries.
• Secondary Infections: Prolonged use of antibiotics and corticosteroids may promote the growth of non-susceptible organisms, including fungi.

Patients should seek immediate medical attention if they experience severe or persistent side effects, especially if they notice vision changes, significant eye pain, or symptoms of an allergic reaction.

Increased Intraocular Pressure: Regular monitoring of intraocular pressure is recommended if the ointment is used for extended periods, as corticosteroids can increase IOP and lead to glaucoma.

Risk of Cataracts: Prolonged use of corticosteroids can increase the risk of developing cataracts. Patients should be monitored for vision changes if long-term use is necessary.

Secondary Infections: The use of antibiotics can lead to the overgrowth of non-susceptible organisms, including fungi. If signs of a new infection develop, discontinue use and consult your healthcare provider.

Blephamide S.O.P. may interact with other medications, particularly other eye medications:

• Other Ophthalmic Medications: If using other eye drops or ointments, wait at least 5 minutes between applications to prevent dilution or interaction of the medications.
• Systemic Corticosteroids: Concurrent use with systemic corticosteroids can increase the risk of systemic side effects.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

Alternative treatments for inflammatory ocular conditions with a bacterial component include:

• Other Combination Eye Drops or Ointments: Such as Tobradex (tobramycin and dexamethasone), which also combine an antibiotic with a corticosteroid.
• Monotherapy Options: Separate antibiotic eye drops (e.g., ofloxacin or ciprofloxacin) and corticosteroid eye drops (e.g., prednisolone acetate) may be used depending on the severity and specific needs of the patient.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Such as ketorolac eye drops, which can reduce inflammation without the risks associated with corticosteroids.

The choice of treatment depends on the specific condition, the patient’s response to previous treatments, and any underlying medical conditions.