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AzaSite
AzaSite (azithromycin ophthalmic solution) is a topical antibiotic used to treat bacterial conjunctivitis (commonly known as pink eye). It belongs to the macrolide antibiotics class and works by stopping the growth of bacteria in the eye. AzaSite is typically used to treat infections caused by susceptible strains of bacteria and is available as an eye drop solution.
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Frequently Asked Questions
How quickly does AzaSite start working?
AzaSite typically starts to relieve symptoms within 2 to 3 days of starting treatment, but it is important to complete the full course to ensure the infection is fully resolved.
Can I wear contact lenses while using AzaSite?
No, you should avoid wearing contact lenses during the course of treatment with AzaSite, as it may aggravate the infection or increase irritation.
What should I do if I miss a dose of AzaSite?
If you miss a dose, apply it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Can AzaSite be used for viral or fungal eye infections?
No, AzaSite is only effective against bacterial infections. It should not be used to treat viral or fungal eye infections.
Is AzaSite safe for use in children?
Yes, AzaSite is safe for use in children aged 1 year and older, under the guidance of a healthcare provider.
Comprehensive Drug Guide
How Does AzaSite Work?
AzaSite works by inhibiting bacterial protein synthesis. Azithromycin, the active ingredient, binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein production necessary for bacterial growth and replication. This action helps to reduce the bacterial infection in the eye and relieve symptoms like redness, irritation, and discharge.
Common Dosages
- Ophthalmic solution: 1% azithromycin
Typical Dosing
- For bacterial conjunctivitis: Instill one drop of AzaSite in the affected eye(s) twice daily for the first two days, followed by one drop once daily for the next five days.
Typical Dosing
FDA Approved Indications
- Bacterial conjunctivitis caused by susceptible strains of bacteria, including Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pneumoniae.
Who Shouldn't Take AzaSite?
- Known hypersensitivity to azithromycin, other macrolide antibiotics, or any component of the formulation.
- Viral or fungal eye infections, as AzaSite is only effective against bacterial infections.
Advice From The Pharmacist
- Wash your hands before applying AzaSite to avoid contaminating the solution.
- Avoid touching the tip of the dropper to any surface, including your eye, to prevent contamination.
- Contact lenses should not be worn during the course of treatment with AzaSite, as they may worsen the infection.
- Store AzaSite in the refrigerator, and allow it to warm to room temperature before using. Do not freeze the solution.
Side Effects of AzaSite
Common Side Effects
- Eye irritation or burning sensation
- Blurred vision
- Dryness or itching of the eyes
Uncommon/Severe Side Effects
- Severe allergic reactions, such as rash, swelling, or difficulty breathing
- Increased risk of other eye infections due to overuse
Risks and Warnings of AzaSite
- Allergic Reactions: Patients with a history of hypersensitivity to macrolides should not use AzaSite, as it may cause allergic reactions, including anaphylaxis.
- Superinfection Risk: Prolonged use of antibiotics, including AzaSite, may result in the overgrowth of non-susceptible organisms, including fungi. If new infections occur, discontinue use and consult your healthcare provider.
- Use in Pregnancy: AzaSite should be used during pregnancy only if clearly needed and prescribed by a healthcare provider.
Interactions with AzaSite
Common Drug Interactions
- Other Eye Medications: AzaSite should not be used concurrently with other eye drops unless directed by a healthcare provider. Using multiple eye medications may dilute the effectiveness of AzaSite or increase irritation.
- Anticoagulants: Azithromycin may interact with certain blood thinners (such as warfarin), increasing the risk of bleeding. Consult with your healthcare provider if you are using both.
Alternatives to AzaSite
- Tobrex (tobramycin): Another antibiotic eye drop used to treat bacterial eye infections.
- Vigamox (moxifloxacin): A fluoroquinolone antibiotic used for bacterial conjunctivitis.
- Polytrim (polymyxin B/trimethoprim): A combination antibiotic eye drop used for a wide range of bacterial eye infections.
- Ofloxacin (generic): A fluoroquinolone antibiotic eye drop used to treat bacterial infections.
