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Tobrex

Tobrex (generic name: tobramycin) is an aminoglycoside antibiotic used to treat bacterial infections of the eye, such as bacterial conjunctivitis and blepharitis. It works by killing the bacteria that cause the infection, thereby reducing symptoms such as redness, swelling, and discomfort. Tobrex is effective against a wide range of bacteria and is commonly prescribed for short-term treatment of eye infections.



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Frequently Asked Questions

How long does it take for Tobrex to work?
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You may notice improvement in your symptoms within 1 to 2 days of starting treatment, but it’s important to continue using the medication for the full prescribed duration to ensure the infection is fully treated.

Can I use Tobrex with contact lenses?
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No, you should not wear contact lenses while using Tobrex, as they can worsen the infection or irritation. Wait until your infection is fully resolved and your doctor gives you the go-ahead before wearing lenses again.

What should I do if I miss a dose of Tobrex?
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If you miss a dose, apply it as soon as you remember. If it’s close to the time of your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Can Tobrex cause blurry vision?
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Yes, temporary blurry vision is a common side effect after applying the eye drops or ointment. This should resolve within a few minutes.

How long should I use Tobrex?
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Tobrex should generally be used for 7 to 10 days or as directed by your doctor. Prolonged use may increase the risk of resistant infections or other complications.

Comprehensive Drug Guide

How Does Tobrex Work?

Tobramycin works by binding to bacterial ribosomes, inhibiting protein synthesis, and leading to bacterial cell death. This prevents the spread of infection and promotes the healing of the affected area.



Common Dosages

  • Ophthalmic solution (eye drops): 0.3% tobramycin
  • Ophthalmic ointment: 0.3% tobramycin

Typical Dosing

  • For bacterial infections of the eye: The usual dose of Tobrex eye drops is one or two drops in the affected eye(s) every 4 hours. In severe infections, the dosage may be increased to every 1 to 2 hours initially. The ointment is typically applied 2 to 3 times daily or as directed by your healthcare provider.


Typical Dosing

FDA Approved Indications

  • Bacterial infections of the eye, such as bacterial conjunctivitis, keratitis, and blepharitis


Who Shouldn't Take Tobrex?

  • Known hypersensitivity to tobramycin or any other components of the formulation


Advice From The Pharmacist

  • Shake the bottle well before each use for the ophthalmic solution.
  • Do not wear contact lenses while using Tobrex, as this can worsen the infection or cause irritation.
  • Complete the full course of treatment even if symptoms improve early, to ensure the infection is fully treated and prevent recurrence.
  • Avoid touching the dropper tip or tube opening to your eye or any surface to prevent contamination.

Side Effects of Tobrex

Common Side Effects

  • Temporary blurred vision
  • Eye redness or irritation
  • Itching or stinging sensation
  • Increased tearing


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Development of resistant bacteria with prolonged use


Risks and Warnings of Tobrex

  • Allergic Reactions: Some individuals may develop allergic reactions to Tobrex, which can lead to worsening symptoms. Discontinue use and consult your healthcare provider if signs of an allergic reaction occur.
  • Prolonged Use: Using Tobrex for extended periods can lead to the growth of non-susceptible organisms, including fungi. It is recommended for short-term use as directed by your healthcare provider.


Interactions with Tobrex

Common Drug Interactions

  • Other aminoglycoside antibiotics: Concurrent use of systemic aminoglycosides (e.g., gentamicin) may increase the risk of additive toxicity. Monitor for signs of toxicity if using more than one aminoglycoside.


Alternatives to Tobrex

  • Polytrim (polymyxin B/trimethoprim): Another antibiotic used to treat bacterial eye infections.
  • Ciprofloxacin (Ciloxan): A fluoroquinolone antibiotic used to treat bacterial conjunctivitis and keratitis.
  • Erythromycin ophthalmic ointment: A macrolide antibiotic used for treating eye infections, particularly in newborns.