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Polytrim
Polytrim (polymyxin B and trimethoprim) is a combination antibiotic used for the treatment of bacterial infections of the eye, particularly conjunctivitis (pink eye) and other superficial infections caused by susceptible organisms. The combination of polymyxin B, a polypeptide antibiotic, and trimethoprim, a sulfonamide antibiotic, provides broad-spectrum coverage against a variety of Gram-positive and Gram-negative bacteria.
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Frequently Asked Questions
How quickly does Polytrim start to work?
Patients may begin to notice improvement in symptoms within a few days of starting treatment, but it is essential to complete the full course of medication for complete resolution of the infection.
Can I stop using Polytrim suddenly?
It is important to complete the entire course of Polytrim as prescribed to ensure that the infection is fully treated. Stopping early may lead to treatment failure.
Are there any specific dietary restrictions while using Polytrim?
There are no specific dietary restrictions associated with Polytrim.
What should I do if I miss a dose of Polytrim?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Polytrim safe for long-term use?
Polytrim is intended for short-term use for treating bacterial eye infections. Long-term use should be monitored by a healthcare provider to assess effectiveness and any potential side effects. Regular follow-ups are important to ensure the resolution of the infection.
Comprehensive Drug Guide
How Does Polytrim Work?
- Polymyxin B works by disrupting the bacterial cell membrane, leading to cell death. It is particularly effective against Gram-negative bacteria.
- Trimethoprim inhibits bacterial dihydrofolate reductase, an enzyme crucial for the synthesis of folate, which is necessary for bacterial growth and replication. This action helps to stop the growth of susceptible bacteria.
Common Dosages
- Ophthalmic solution: Each mL contains 10000 units of polymyxin B and 1 mg of trimethoprim.
Typical Dosing
- The usual recommended dosing is 1 to 2 drops in the affected eye(s) every 3 hours during waking hours for 7 to 10 days. Dosing may be adjusted based on the severity of the infection and the healthcare provider's discretion.
Typical Dosing
FDA Approved Indications
- Treatment of superficial bacterial infections of the eye, including conjunctivitis caused by susceptible bacteria.
Who Shouldn't Take Polytrim?
- Known hypersensitivity to polymyxin B, trimethoprim, or any components of the formulation.
- History of severe allergic reactions to other antibiotics in the same class.
Advice From The Pharmacist
- Instruct patients on the proper technique for administering eye drops, emphasizing the importance of avoiding contact between the dropper and any surface, including the eye.
- Advise patients to complete the full course of treatment as prescribed, even if symptoms improve before finishing the medication.
- Discuss potential side effects and encourage patients to report any persistent or severe symptoms, such as increased redness, swelling, or discharge from the eye.
Side Effects of Polytrim
Common Side Effects
- Eye irritation or discomfort
- Burning or stinging upon application
- Dry eyes
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Increased redness, swelling, or discharge from the eye, which may indicate worsening infection or a new one.
Risks and Warnings of Polytrim
- Infection Risk: Prolonged use of topical antibiotics can lead to the overgrowth of non-susceptible organisms, including fungi. Monitor patients for signs of secondary infection.
- Contact Lens Use: Patients should avoid wearing contact lenses while using Polytrim, as this can increase the risk of eye infections.
Interactions with Polytrim
Common Drug Interactions
- Other Ophthalmic Medications: Patients should inform their healthcare provider about all medications they are using, including other eye drops, to avoid potential interactions and to ensure appropriate timing of administration.
Alternatives to Polytrim
- Other Ophthalmic Antibiotics: Alternatives may include other topical antibiotics such as ciprofloxacin or ofloxacin for treating bacterial eye infections, depending on the specific bacteria involved and patient considerations.
