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Ayuna
Ayuna (desogestrel and ethinyl estradiol) is a combination oral contraceptive that contains progestin (desogestrel) and estrogen (ethinyl estradiol). It is used primarily for birth control to prevent pregnancy. Ayuna works by inhibiting ovulation, altering the cervical mucus to hinder sperm movement, and changing the lining of the uterus to prevent implantation of a fertilized egg. It is also used for menstrual cycle regulation, reduction of menstrual cramps, and treatment of acne in some patients.
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Frequently Asked Questions
Can Ayuna cause weight gain?
Some women may experience slight weight gain, but significant changes in weight are uncommon while using Ayuna.
What should I do if I miss a pill?
If you miss one active pill, take it as soon as you remember and take the next pill at your regular time. If you miss two or more active pills, consult the patient leaflet or your healthcare provider, as backup contraception may be needed.
Can Ayuna help with acne?
Yes, Ayuna may be prescribed to help reduce acne in some patients, as the hormones can decrease the production of sebum (oil) in the skin.
Can I take Ayuna while breastfeeding?
Ayuna is not recommended for use during breastfeeding, as it may reduce milk supply. Progestin-only contraceptives are a better option for breastfeeding mothers.
Does Ayuna protect against sexually transmitted infections (STIs)?
No, Ayuna does not protect against STIs. You should use condoms or other barrier methods to protect against infections.
Comprehensive Drug Guide
How Does Ayuna Work?
Ayuna works by preventing ovulation (the release of an egg from the ovaries). It also thickens the cervical mucus, making it harder for sperm to enter the uterus and fertilize an egg. Additionally, it alters the uterine lining, making it less suitable for implantation of a fertilized egg, further preventing pregnancy.
Common Dosages
- Oral tablets: Each pack contains 21 active tablets with desogestrel 0.15 mg and ethinyl estradiol 0.03 mg, plus 7 inactive (placebo) tablets.
Typical Dosing
- For contraception: Take one active tablet daily for 21 consecutive days, followed by one inactive tablet daily for 7 days to complete the 28-day cycle. Start a new pack immediately after finishing the 28-day cycle.
Typical Dosing
FDA Approved Indications
- Contraception to prevent pregnancy
Who Shouldn't Take Ayuna?
- Known hypersensitivity to desogestrel, ethinyl estradiol, or any component of the formulation.
- History of blood clots, stroke, or heart attack.
- Uncontrolled high blood pressure.
- Liver disease.
- Breast cancer or other hormone-sensitive cancers.
- Pregnancy.
Advice From The Pharmacist
- Take Ayuna at the same time each day to maintain consistent hormone levels and maximize its effectiveness.
- If you miss a dose, refer to the patient information leaflet for guidance. Backup contraception (such as condoms) may be needed depending on how many doses were missed.
- Ayuna does not protect against sexually transmitted infections (STIs). Use condoms or other barrier methods to protect against STIs.
- Be sure to inform your healthcare provider about any medications or supplements you are taking, as some drugs can reduce the effectiveness of Ayuna.
Side Effects of Ayuna
Common Side Effects
- Nausea
- Headache
- Breast tenderness
- Mood changes
- Breakthrough bleeding (spotting between periods)
Uncommon/Severe Side Effects
- Blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism)
- Stroke
- Liver problems
- High blood pressure
Risks and Warnings of Ayuna
- Blood Clot Risk: Combination oral contraceptives like Ayuna increase the risk of blood clots, especially in women who smoke and are over the age of 35. Avoid smoking while using Ayuna to reduce this risk.
- Cancer Risk: Ayuna may slightly increase the risk of breast and cervical cancers. Routine screenings are recommended for women taking hormonal contraceptives.
- Liver Disease: Ayuna should not be used by women with severe liver disease, as it can worsen liver function.
Interactions with Ayuna
Common Drug Interactions
- Antibiotics: Some antibiotics, such as rifampin, can decrease the effectiveness of Ayuna. Backup contraception may be needed while taking these medications.
- Antiepileptic Drugs: Certain seizure medications can reduce the effectiveness of Ayuna. Use additional contraceptive methods if needed.
- St. John's Wort: This herbal supplement can reduce the effectiveness of Ayuna and lead to unintended pregnancy.
Alternatives to Ayuna
- Ortho Tri-Cyclen (norgestimate and ethinyl estradiol): A combination oral contraceptive that is also used to treat acne.
- Lo Loestrin Fe (norethindrone acetate and ethinyl estradiol): A low-dose oral contraceptive option.
- Nexplanon: A long-acting contraceptive implant that lasts for up to three years.
- Depo-Provera (medroxyprogesterone acetate): An injectable contraceptive that lasts for three months.
