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medroxyPROGESTERone Acetate
Medroxyprogesterone acetate is a synthetic form of the hormone progesterone. It is primarily used in various therapeutic applications, including the treatment of abnormal uterine bleeding, endometriosis, and as a part of hormone replacement therapy. It is also used as a contraceptive when administered as an injection.
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Frequently Asked Questions
How long does it take for medroxyprogesterone acetate to work?
The onset of action varies; for contraception, it is effective immediately if injected during the first 5 days of the menstrual cycle.
Can I use medroxyprogesterone acetate while breastfeeding?
Consult your healthcare provider, as it can be used during breastfeeding but may require monitoring.
What should I do if I miss a dose?
For oral doses, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose. For injections, follow your healthcare provider's advice regarding rescheduling.
Are there any dietary restrictions while taking medroxyprogesterone acetate?
There are no specific dietary restrictions, but maintaining a balanced diet is advisable.
Is it safe to smoke while taking medroxyprogesterone acetate?
Smoking increases the risk of cardiovascular side effects and is generally discouraged, especially in women over 35 who take hormonal contraceptives.
Comprehensive Drug Guide
How Does medroxyPROGESTERone Acetate Work?
Medroxyprogesterone acetate works by mimicking the effects of natural progesterone in the body. It helps regulate the menstrual cycle, thickens the cervical mucus to inhibit sperm passage, and alters the uterine lining to prevent the implantation of a fertilized egg. In hormone replacement therapy, it balances estrogen effects on the endometrium.
Common Dosages
- Tablets: 2.5 mg, 5 mg, and 10 mg.
- Injectable: Typically 150 mg/mL for contraceptive use.
Typical Dosing
- For abnormal uterine bleeding: The typical dosing may vary; often, 10 mg to 20 mg taken for 5 to 10 days in a cycle.
- For endometriosis: 10 mg to 100 mg daily may be prescribed for specific durations.
- For contraception: An injection of 150 mg every 3 months (12 weeks) is recommended.
Typical Dosing
FDA Approved Indications
- Abnormal Uterine Bleeding: treatment of excessive or irregular menstrual bleeding.
- Endometriosis: management of symptoms associated with endometriosis.
- Hormone Replacement Therapy: to reduce the risk of endometrial hyperplasia in women with a uterus receiving estrogen.
- Contraception: as a long-acting injectable contraceptive (Depo-Provera).
Who Shouldn't Take medroxyPROGESTERone Acetate?
- Known hypersensitivity to medroxyprogesterone or any component of the formulation.
- History of thromboembolic disorders, stroke, or liver disease.
- Undiagnosed abnormal genital bleeding.
Advice From The Pharmacist
- Take medroxyprogesterone acetate exactly as prescribed, and do not exceed the recommended dosage.
- For the injectable form, ensure to return for your scheduled injections to maintain contraceptive effectiveness.
- Monitor for any unusual side effects and report them to your healthcare provider.
Side Effects of medroxyPROGESTERone Acetate
Common Side Effects
- Weight gain
- Headaches
- Breast tenderness
- Mood changes
- Spotting or changes in menstrual flow
Uncommon/Severe Side Effects
- Signs of a blood clot (swelling, pain, sudden shortness of breath)
- Severe allergic reactions (rash, itching, swelling)
- Liver dysfunction (jaundice, severe abdominal pain)
Risks and Warnings of medroxyPROGESTERone Acetate
- Cardiovascular Risk: Progestins can increase the risk of thromboembolic events, especially in women with pre-existing risk factors.
- Bone Density: Long-term use of medroxyprogesterone acetate for contraception can lead to decreased bone mineral density.
- Hormonal Changes: Be aware of potential changes in mood or mental health; discuss any concerns with your healthcare provider.
Interactions with medroxyPROGESTERone Acetate
Common Drug Interactions
- Anticonvulsants: Certain medications may reduce the effectiveness of medroxyprogesterone acetate.
- Antibiotics: Some antibiotics can affect hormone metabolism, so it's essential to discuss any medications you are taking with your healthcare provider.
Alternatives to medroxyPROGESTERone Acetate
- Other Progestins: Such as norethindrone or levonorgestrel for similar indications.
- Combination Oral Contraceptives: For contraception and management of menstrual disorders.
- Intrauterine Devices (IUDs): Such as hormonal IUDs for long-term contraception.
