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Depo-Provera
Depo-Provera is a progestin-only contraceptive injection that contains medroxyprogesterone acetate. It is used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, making it more difficult for sperm to reach an egg and for a fertilized egg to implant. Depo-Provera is typically administered as an intramuscular injection every three months and is also prescribed for certain medical conditions, such as endometriosis and abnormal uterine bleeding.
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Frequently Asked Questions
How long does Depo-Provera take to start working?
Depo-Provera is effective at preventing pregnancy within 24 hours if given during the first five days of your menstrual cycle. If administered at another time, use backup contraception for seven days.
Can I stop using Depo-Provera at any time?
Yes, you can stop Depo-Provera at any time, but it may take several months to a year for your fertility to return and for regular menstrual cycles to resume.
What happens if I miss my scheduled Depo-Provera injection?
If you miss your injection by more than two weeks, you should use backup contraception (such as condoms) and contact your healthcare provider as soon as possible to schedule the next injection.
Does Depo-Provera cause weight gain?
Weight gain is a common side effect of Depo-Provera. Some women may experience significant weight changes over time, so regular monitoring of weight and lifestyle adjustments may help.
Can Depo-Provera protect against sexually transmitted infections (STIs)?
No, Depo-Provera does not provide protection against STIs. Use condoms or other barrier methods to reduce the risk of STIs.
Comprehensive Drug Guide
How Does Depo-Provera Work?
Depo-Provera works by delivering a high dose of medroxyprogesterone acetate, which inhibits the release of gonadotropins (LH and FSH). This prevents ovulation, thickens cervical mucus to block sperm entry, and alters the uterine lining, making it less suitable for implantation.
What is Depo-Provera Used For?
- Prevention of pregnancy
- Management of endometriosis
- Treatment of abnormal uterine bleeding
- Reduction of pain from endometriosis
Common Dosages
Depo-Provera is available in the following strengths:
- 150 mg/mL intramuscular injection
Typical Dosing
FDA Approved Indications
- The recommended dose is 150 mg administered intramuscularly every 12 weeks. To maintain effective contraception, it is important to receive the injection on time every three months.
Who Shouldn't Take Depo-Provera?
Depo-Provera should not be used in individuals with:
- Active or history of thromboembolic disorders
- Known or suspected breast cancer
- Liver disease
- Known hypersensitivity to medroxyprogesterone or any component of the formulation
- Unexplained vaginal bleeding
Advice From The Pharmacist
- Depo-Provera should be administered by a healthcare provider in a clinic setting every three months.
- You may experience changes in your menstrual cycle, including irregular bleeding or no periods. This is a common effect and may persist for as long as you use the injection.
- Long-term use of Depo-Provera can cause bone density loss, so discuss with your healthcare provider the potential need for calcium and vitamin D supplements or other preventative measures for bone health.
- Depo-Provera does not protect against sexually transmitted infections (STIs), so use additional barrier protection methods such as condoms if necessary.
Side Effects of Depo-Provera
Common Side Effects
- Irregular or absent menstrual periods
- Weight gain
- Headache
- Decreased bone mineral density
- Mood changes
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Severe abdominal or pelvic pain
- Signs of blood clots (e.g., leg pain, shortness of breath)
Risks and Warnings of Depo-Provera
Bone Density Loss: Long-term use of Depo-Provera (more than two years) may cause a decrease in bone density, which can increase the risk of fractures. This effect may be reversible after discontinuation, but bone health should be closely monitored during long-term use.
Weight Gain: Many women experience weight gain while using Depo-Provera. Regular exercise and a balanced diet may help mitigate this effect.
Delayed Fertility: After stopping Depo-Provera, it may take several months to a year for regular menstrual cycles and fertility to return. If you are planning to become pregnant in the near future, consider discussing other contraceptive options with your healthcare provider.
Interactions with Depo-Provera
Common Drug Interactions
- Corticosteroids: Concomitant use of Depo-Provera with corticosteroids may increase the risk of bone density loss.
- Aminoglutethimide: This medication may reduce the effectiveness of Depo-Provera.
- Other Hormonal Contraceptives: Avoid using other hormonal contraceptives while on Depo-Provera, unless directed by your healthcare provider.
Alternatives to Depo-Provera
- Nexplanon: A progestin implant that provides long-term birth control for up to three years.
- Mirena: A hormonal intrauterine device (IUD) that provides contraception for up to five years.
- Oral contraceptives: Combination birth control pills taken daily to prevent pregnancy.
- Copper IUD: A non-hormonal IUD that provides contraception for up to ten years.
