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Provera
Provera (medroxyprogesterone acetate) is a progestin medication used in hormone therapy for various conditions. It is primarily prescribed for the treatment of amenorrhea (absence of menstrual periods), abnormal uterine bleeding, and for the prevention of endometrial hyperplasia in postmenopausal women who are receiving estrogen. Provera can also be used in the management of certain cancers and as part of a contraceptive regimen.
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Frequently Asked Questions
How quickly does Provera start to work?
The onset of action can vary; some patients may notice changes in their menstrual cycle within a few days, while others may take longer to experience effects.
Can I stop taking Provera suddenly?
It is generally safe to stop taking Provera as prescribed; however, consult your healthcare provider for guidance, especially if you have been using it for an extended period.
Are there any specific dietary restrictions while taking Provera?
There are no specific dietary restrictions, but maintaining a healthy diet can support overall well-being during treatment.
What should I do if I miss a dose of Provera?
If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Provera safe for long-term use?
Provera can be used long-term under medical supervision, especially for managing certain conditions. Regular follow-up appointments are essential to monitor for side effects and evaluate the ongoing need for therapy.
Comprehensive Drug Guide
How Does Provera Work?
Medroxyprogesterone acetate works by mimicking the effects of progesterone, a natural hormone in the body. It acts on the endometrial lining of the uterus, promoting changes that prepare the lining for potential implantation of a fertilized egg, or causing it to shed if pregnancy does not occur. This action helps regulate the menstrual cycle and prevent abnormal uterine growth.
Common Dosages
- Tablets: 2.5 mg, 5 mg, and 10 mg.
Typical Dosing
- For secondary amenorrhea: The usual dose is 5 to 10 mg taken once daily for 5 to 10 days.
- For abnormal uterine bleeding: The usual dose is 10 mg taken once daily for 5 to 14 days.
- For endometrial hyperplasia prevention: 5 mg to 10 mg daily is typically prescribed for a cyclic regimen.
Typical Dosing
FDA Approved Indications
- Treatment of secondary amenorrhea.
- Management of abnormal uterine bleeding due to hormonal imbalance.
- Prevention of endometrial hyperplasia in postmenopausal women taking estrogen.
- Treatment of certain types of endometrial or renal cancer (as part of combination therapy).
Who Shouldn't Take Provera?
- Known hypersensitivity to medroxyprogesterone acetate or any components of the formulation.
- History of thromboembolic disorders (such as deep vein thrombosis or pulmonary embolism).
- Undiagnosed vaginal bleeding or known or suspected pregnancy.
Advice From The Pharmacist
- Advise patients to take Provera exactly as prescribed and to adhere to the dosing schedule to maximize effectiveness.
- Monitor for side effects, such as changes in menstrual cycle, weight gain, or mood changes, and report any severe or persistent reactions to their healthcare provider.
- Discuss lifestyle modifications, such as diet and exercise, to mitigate potential weight gain associated with progestin therapy.
Side Effects of Provera
Common Side Effects
- Weight gain
- Breast tenderness
- Headache
- Mood changes
- Nausea
Uncommon/Severe Side Effects
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Thromboembolic events (deep vein thrombosis or pulmonary embolism)
- Changes in vision or migraines
Risks and Warnings of Provera
- Cardiovascular Risks: Patients should be monitored for signs of thromboembolic events, especially those with a history of such conditions.
- Hormonal Effects: Regular follow-up is important to assess the effectiveness of treatment and monitor for any adverse effects related to hormonal changes.
Interactions with Provera
Common Drug Interactions
- Anticonvulsants: Certain anticonvulsants (like phenytoin) may reduce the effectiveness of Provera and require dose adjustments.
- Antibiotics: Some antibiotics may affect the metabolism of Provera, potentially leading to altered efficacy.
Alternatives to Provera
- Other Progestins: Such as norethindrone or progesterone, may be considered for similar indications based on patient-specific factors.
- Combined Hormonal Contraceptives: May be used for similar purposes in some cases.
