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Apriso
Apriso is a type of medication recognized in the group of antiinflammatory agents, particularly recognized as an aminosalicylate. It is mainly used for the management of ulcerative colitis, an inflammatory bowel disease. Some common side effects include headaches, diarrhea, or abdominal pain, but the downsides are frequently outweighed by the relief it brings to the patient?s symptoms.
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Frequently Asked Questions
How long does it take for Apriso to start working?
Apriso is primarily used for maintenance, so its effects may not be immediately noticeable. It works over time to keep the inflammation under control and prevent flare-ups.
Can I take Apriso with other medications for ulcerative colitis?
Yes, Apriso is often used in combination with other medications, such as immunosuppressants or corticosteroids. However, always consult your healthcare provider before combining treatments.
Can Apriso cause kidney problems?
Yes, Apriso can cause kidney issues, such as interstitial nephritis, especially with long-term use. Your healthcare provider may monitor your kidney function during treatment.
What should I do if I miss a dose of Apriso?
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
Is Apriso safe to use during pregnancy?
Apriso may be used during pregnancy if the potential benefits outweigh the risks. It is important to consult with your healthcare provider to discuss your specific situation and the best treatment plan for you.
Comprehensive Drug Guide
How Does Apriso Work?
Apriso is a slowrelease oral capsule that assists in the release of mesalamine in the terminal ileum and beyond for the treatment of ulcerative colitis.
What is Apriso Used For?
FDA indications: Apriso is used to treat ulcerative colitis and maintain remission.
Offlabel uses: Some healthcare providers might use it for offlabel treatment of Crohn's Disease, though this varies by case.
Common Dosages
Capsules: 0.375g
XR Capsules: 0.375g
Typical Dosing
FDA Approved Indications
- Ulcerative colitis: The typical dose is 1.5g (four 0.375g capsules) once a day in the morning.
Off-Label Uses
- Crohn's Disease: Dosing varies depending on severity and is at the discretion of the healthcare provider.
Who Shouldn't Take Apriso?
- Have kidney disease or abnormal renal function tests.
- Have pyloric stenosis or any other conditions that obstruct the gastric outlet.
- Are hypersensitive to salicylates or aminosalicylates or their derivatives.
- Are allergic to any ingredient of Apriso.
- Have a history of myocarditis or pericarditis
Advice From The Pharmacist
- Take Apriso in the morning with a meal to help ensure full absorption.
- It might be easier on your stomach if you take it with food or milk.
- Do not crush or chew Apriso. It's designed to be absorbed slowly to be more effective.
- If you're having trouble swallowing, let your doctor know. They may suggest an alternative.
- Do not stop taking Apriso suddenly. Always follow your doctor's instructions.
- Keep all your doctor appointments and get regular checkups.
- Taking an antacid may increase the blood levels of Apriso. It may be best to separate the time of antacid from Apriso taking.
Side Effects of Apriso
Common Side Effects
- You might have headaches, diarrhea, or abdominal pain.
- You might experience nausea or vomiting.
- You could have flulike symptoms.
Uncommon/Severe Side Effects
- Uncommon Side Effects:
- You might feel dizzy or have vertigo.
- You may experience hair loss.
- You could have difficulty sleeping or have abnormal dreams.
- Rare Side Effects:
- You might have a disturbance in vision.
- You may experience hallucinations.
- You could have mood changes.
- Severe Side Effects:
- You might have bloody diarrhea.
- Your urine may turn a darker color.
- Signs of an allergic reaction such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing need immediate medical attention.
Risks and Warnings of Apriso
- Remember, Apriso is not suitable for everyone. It should be avoided if you have a known hypersensitivity to salicylates or aminosalicylates, or if you have any impairment in kidney function or gastric outlet obstruction.
- It should also be used with caution in patients with a history of cardiac conditions such as myocarditis and pericarditis.
Interactions with Apriso
Common Drug Interactions
- Digoxin
- Anticoagulants (like warfarin)
- Probenecid
- Sulfinpyrazone
- Rifampin
- Methotrexate
Alternatives to Apriso
- Azulfidine
- Asacol
- Balsalazide
- Colazal
- Dipentum
- Lialda
