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ZyPREXA Zydis

Zyprexa Zydis (olanzapine) is an atypical antipsychotic medication that comes in an orally disintegrating tablet (ODT) form. It is primarily used to treat schizophrenia and bipolar disorder in adults and adolescents. Zyprexa Zydis works by affecting the activity of dopamine and serotonin in the brain, helping to manage symptoms such as hallucinations, delusions, mood swings, and irritability. The orally disintegrating formulation is particularly helpful for patients who have difficulty swallowing traditional tablets.

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Frequently Asked Questions

How does Zyprexa Zydis differ from regular Zyprexa?
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Zyprexa Zydis is an orally disintegrating tablet (ODT) that dissolves on the tongue, whereas regular Zyprexa comes as a standard tablet that must be swallowed. Zyprexa Zydis is ideal for patients who have difficulty swallowing pills.

How long does it take for Zyprexa Zydis to work?
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Some symptoms, such as agitation, may improve within a few days, but it may take several weeks to see the full benefits of Zyprexa Zydis for mood stabilization and psychosis.

Can I take Zyprexa Zydis with food?
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Yes, Zyprexa Zydis can be taken with or without food. The orally disintegrating tablets dissolve on the tongue without the need for water.

Can Zyprexa Zydis cause weight gain?
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Yes, weight gain is a common side effect of Zyprexa Zydis, and patients should monitor their weight regularly while on the medication.

What should I do if I miss a dose of Zyprexa Zydis?
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If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.

Comprehensive Drug Guide

How Does ZyPREXA Zydis Work?

Zyprexa Zydis works by modulating the activity of dopamine and serotonin, two key neurotransmitters involved in mood regulation and thought processes. By reducing the effects of these neurotransmitters, Zyprexa Zydis helps alleviate symptoms of schizophrenia and bipolar disorder, including psychosis, mood instability, and disorganized thinking.

Common Dosages

  • 5 mg, 10 mg, 15 mg, 20 mg orally disintegrating tablets

Typical Dosing

  • For schizophrenia: The typical starting dose is 5-10 mg daily, with maintenance doses ranging from 10-20 mg daily.
  • For bipolar disorder: The dose is usually 10-15 mg daily, with adjustments based on response and tolerance.
  • For depression (with fluoxetine): The usual dose of olanzapine in combination with fluoxetine is 5-12.5 mg daily.

Typical Dosing

FDA Approved Indications

  • Schizophrenia in adults and adolescents aged 13-17
  • Bipolar I disorder (both manic and mixed episodes) in adults and adolescents aged 13-17
  • As an adjunctive treatment for depression in combination with fluoxetine (under the brand name Symbyax)

Who Shouldn't Take ZyPREXA Zydis?

  • Known hypersensitivity to olanzapine or any components of the formulation.
  • Severe liver impairment.

Advice From The Pharmacist

  • Zyprexa Zydis tablets dissolve on the tongue and do not require water. Simply place the tablet in your mouth and allow it to dissolve.
  • Be aware that Zyprexa Zydis may cause drowsiness, so avoid driving or operating heavy machinery until you know how the medication affects you.
  • Weight gain and metabolic changes (such as increased blood sugar) are possible with Zyprexa Zydis. Regular monitoring of weight, blood sugar, and cholesterol is recommended during treatment.
  • Do not drink alcohol while taking Zyprexa Zydis, as it can increase the risk of sedation and drowsiness.

Side Effects of ZyPREXA Zydis

Common Side Effects

  • Weight gain
  • Drowsiness or sedation
  • Increased appetite
  • Dry mouth
  • Constipation

Uncommon/Severe Side Effects

  • Tardive dyskinesia: Involuntary movements, particularly of the face and tongue, which can become permanent with long-term use.
  • Neuroleptic malignant syndrome (NMS): A rare but life-threatening reaction characterized by muscle rigidity, fever, and altered mental status.
  • Metabolic changes: Such as increased blood sugar or cholesterol levels, leading to a higher risk of diabetes or heart disease.

Risks and Warnings of ZyPREXA Zydis

  • Weight Gain and Metabolic Changes: Zyprexa Zydis is associated with significant weight gain and metabolic changes such as elevated blood sugar and cholesterol. Regular monitoring is necessary.
  • Tardive Dyskinesia: Long-term use of Zyprexa Zydis may lead to tardive dyskinesia, a potentially irreversible movement disorder.
  • Neuroleptic Malignant Syndrome (NMS): This rare but serious condition requires immediate medical attention if symptoms such as muscle stiffness, fever, or confusion occur.
  • Orthostatic Hypotension: Zyprexa Zydis can cause a sudden drop in blood pressure when moving from sitting to standing, leading to dizziness or fainting.

Interactions with ZyPREXA Zydis

Common Drug Interactions

  • Central Nervous System Depressants: Combining Zyprexa Zydis with alcohol, sedatives, or other medications that depress the central nervous system can increase drowsiness and sedation.
  • Antihypertensive medications: Zyprexa Zydis may enhance the effects of blood pressure-lowering drugs, increasing the risk of low blood pressure.
  • Carbamazepine: This medication can reduce the effectiveness of olanzapine by lowering its blood levels.

Alternatives to ZyPREXA Zydis

  • Risperidone (Risperdal): Another atypical antipsychotic used for schizophrenia and bipolar disorder.
  • Quetiapine (Seroquel): Commonly used for mood stabilization in bipolar disorder and schizophrenia, as well as for depression.
  • Aripiprazole (Abilify): An atypical antipsychotic with a lower risk of metabolic side effects, used for schizophrenia and bipolar disorder.