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Zyclara
Zyclara (imiquimod) is a topical immune response modifier used for the treatment of actinic keratosis (AK), external genital warts, and superficial basal cell carcinoma (sBCC). It works by stimulating the immune system to produce cytokines and other substances that help destroy abnormal skin cells or warts. Zyclara is applied directly to the affected skin to help treat conditions caused by sun damage or certain types of viral infections.
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Frequently Asked Questions
How long does it take for Zyclara to work?
The treatment duration depends on the condition being treated. For actinic keratosis, noticeable improvement typically occurs within 2-4 weeks of use. For genital warts, it may take up to 8 weeks for the warts to completely disappear.
Can Zyclara be used on other areas of the body?
Zyclara is approved for use on the face, scalp, and genital areas. It should not be used on mucous membranes or internally. Avoid using Zyclara on areas of the body that have open sores, broken skin, or areas affected by other conditions unless advised by your healthcare provider.
What should I do if I miss a dose of Zyclara?
If you miss a dose, apply it as soon as you remember. If it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for the missed one.
Can I use Zyclara while pregnant or breastfeeding?
Zyclara should only be used during pregnancy or breastfeeding if clearly needed and prescribed by your healthcare provider. It is important to discuss potential risks and benefits with your doctor before using the medication during pregnancy or while breastfeeding.
Can Zyclara cure genital warts?
Zyclara can help treat and clear genital warts caused by the human papillomavirus (HPV), but it does not cure the underlying infection. Genital warts may recur after treatment, as HPV can remain in the body even after the warts have disappeared.
Comprehensive Drug Guide
How Does Zyclara Work?
Zyclara works by activating the body's immune system. It stimulates the production of cytokines, including interferon-alpha, which helps to boost the immune response against abnormal or infected cells. This action helps the body fight actinic keratosis lesions, genital warts caused by the human papillomavirus (HPV), and superficial basal cell carcinoma.
Common Dosages
- 2.5% cream
- 3.75% cream
Typical Dosing
- For actinic keratosis: Apply a thin layer of Zyclara once daily to the affected area before bedtime for 2 weeks, followed by a 2-week rest period and a repeat of the 2-week application period if needed.
- For genital warts: Apply Zyclara once daily before bedtime until the warts are gone, for up to 8 weeks.
- For superficial basal cell carcinoma: Apply Zyclara once daily to the lesion for 6 weeks.
Typical Dosing
FDA Approved Indications
- Actinic keratosis (AK) on the face and scalp in adults
- External genital and perianal warts (condyloma acuminatum) in patients aged 12 years and older
- Superficial basal cell carcinoma (sBCC) when surgery is not appropriate
Who Shouldn't Take Zyclara?
- Known hypersensitivity to imiquimod or any components of the cream.
- Patients with severely compromised immune systems without consulting a healthcare provider.
Advice From The Pharmacist
- Zyclara is for external use only. Do not apply it to areas of broken or infected skin.
- Apply the cream at bedtime and wash it off with mild soap and water after 8 hours.
- Avoid sun exposure to the treated area, as Zyclara may increase the skin's sensitivity to sunlight. Use sunscreen and protective clothing during treatment.
- Do not cover the treated area with bandages unless directed by your healthcare provider.
- If skin irritation becomes severe, stop using the cream and consult your healthcare provider.
Side Effects of Zyclara
Common Side Effects
- Redness, itching, or burning at the application site
- Flaking or scaling of the skin
- Swelling or crusting at the site of application
Uncommon/Severe Side Effects
- Severe skin reactions, such as intense redness, blistering, or open sores
- Flu-like symptoms, including fever, chills, or body aches
- Swelling of the lymph nodes
Risks and Warnings of Zyclara
- Skin Reactions: Zyclara may cause significant local skin reactions such as redness, swelling, and crusting at the application site. These reactions are generally a sign that the medication is working, but if they become severe, consult your healthcare provider.
- Photosensitivity: Zyclara may increase the skin's sensitivity to sunlight, leading to a higher risk of sunburn. Patients should avoid excessive sun exposure and use sunscreen during treatment.
- Flu-like Symptoms: Some patients may experience flu-like symptoms, such as body aches or fatigue, while using Zyclara. These symptoms should resolve with discontinuation of the treatment.
Interactions with Zyclara
Common Drug Interactions
- Immunosuppressive medications: Caution should be exercised when using Zyclara with immunosuppressive drugs, as it may enhance the immune response and increase the risk of side effects.
- There are no significant drug interactions when Zyclara is used topically, but inform your healthcare provider of any other medications you are taking.
Alternatives to Zyclara
- Aldara (imiquimod 5%): Another imiquimod-based topical cream used for the treatment of actinic keratosis, genital warts, and superficial basal cell carcinoma.
- Fluorouracil (Efudex): A topical chemotherapy agent used to treat actinic keratosis and superficial skin cancers.
- Cryotherapy: A freezing technique used to treat actinic keratosis and genital warts.
