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Zontivity
Zontivity (vorapaxar) is an antiplatelet medication used to reduce the risk of cardiovascular events such as heart attack or stroke in patients with a history of heart attack or peripheral arterial disease (PAD). It works by inhibiting platelet aggregation, which helps prevent blood clots from forming in arteries. Zontivity is often prescribed alongside other antiplatelet medications, such as aspirin or clopidogrel, to enhance protection against blood clots in high-risk individuals.
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Frequently Asked Questions
How long does Zontivity take to work?
Zontivity begins working to reduce platelet aggregation shortly after the first dose, but its effects on preventing cardiovascular events are long-term. Consistent daily use is essential for ongoing protection.
Can I stop taking Zontivity if I feel better?
No, Zontivity is typically prescribed for long-term use to prevent serious cardiovascular events like heart attacks or strokes. Stopping it suddenly may increase your risk of these events. Always consult your doctor before stopping.
Does Zontivity cause weight gain?
Weight gain is not a common side effect of Zontivity. However, if you experience any unexpected weight changes, speak with your healthcare provider.
Can I take Zontivity if I’m on blood thinners?
Zontivity should be used with caution if you are already taking anticoagulants (blood thinners), as this can increase the risk of severe bleeding. Your healthcare provider will assess whether combination therapy is appropriate for you.
What should I do if I miss a dose of Zontivity?
If you miss a dose, take it as soon as you remember, but skip the missed dose if it's almost time for your next scheduled dose. Do not double up on doses.
Comprehensive Drug Guide
How Does Zontivity Work?
Zontivity works by blocking protease-activated receptor-1 (PAR-1) on platelets, preventing them from clumping together and forming blood clots. This action reduces the likelihood of harmful clot formation in the arteries, which can lead to heart attacks or strokes. Zontivity is used to provide long-term protection against these cardiovascular events, especially in patients with a history of heart attack or peripheral arterial disease.
Common Dosages
- 2.08 mg tablet: Taken once daily
Typical Dosing
- For cardiovascular event prevention: The recommended dose is 2.08 mg once daily, taken with or without food. It is often used in combination with aspirin or clopidogrel.
Typical Dosing
FDA Approved Indications
- Myocardial infarction (heart attack) in patients with a history of heart attack
- Stroke in patients with a history of heart attack or peripheral arterial disease (PAD)
Who Shouldn't Take Zontivity?
- History of stroke, transient ischemic attack (TIA), or intracranial hemorrhage
- Active pathological bleeding (e.g., peptic ulcer, hemorrhage)
- Severe liver impairment
Advice From The Pharmacist
- Take Zontivity at the same time each day, with or without food. Do not stop taking Zontivity without consulting your healthcare provider, as stopping abruptly can increase your risk of heart attack or stroke.
- Zontivity increases the risk of bleeding, so avoid activities that could lead to injury. Inform your doctor of any signs of unusual bleeding, such as blood in the urine or stools, or prolonged bleeding from cuts.
- If you need surgery or dental work, inform your healthcare provider that you are taking Zontivity, as it may increase bleeding risk.
- Zontivity is usually taken along with other antiplatelet medications like aspirin or clopidogrel. Make sure to follow your prescribed regimen closely.
Side Effects of Zontivity
Common Side Effects
- Bruising
- Bleeding gums
- Nosebleeds
- Anemia (low red blood cell count)
Uncommon/Severe Side Effects
- Severe bleeding (gastrointestinal bleeding, intracranial hemorrhage)
- Hemorrhagic stroke
- Prolonged or uncontrollable bleeding
Risks and Warnings of Zontivity
- Increased Bleeding Risk: Zontivity significantly increases the risk of bleeding, particularly in patients with a history of gastrointestinal bleeding or other conditions that affect blood clotting. Patients should be monitored for signs of bleeding.
- Avoid in Patients with a History of Stroke: Zontivity is contraindicated in patients with a history of stroke or TIA due to the increased risk of hemorrhagic events.
- Combination Therapy: When taken with other antiplatelet agents (aspirin, clopidogrel), the risk of bleeding may be further increased. Careful monitoring is required.
Interactions with Zontivity
Common Drug Interactions
- Anticoagulants: Taking Zontivity with blood thinners like warfarin or heparin can increase the risk of bleeding.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Combining Zontivity with NSAIDs (e.g., ibuprofen, naproxen) may increase the risk of gastrointestinal bleeding.
- Other antiplatelet drugs: The risk of bleeding increases when Zontivity is combined with aspirin, clopidogrel, or similar medications.
Alternatives to Zontivity
- Aspirin: Commonly used as an antiplatelet agent for heart attack and stroke prevention.
- Clopidogrel (Plavix): Another antiplatelet medication used to prevent heart attacks and strokes, often combined with Zontivity.
- Ticagrelor (Brilinta): A potent antiplatelet agent used to reduce the risk of cardiovascular events in patients with acute coronary syndrome or a history of heart attack.
