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Zipsor
Zipsor (generic name: diclofenac potassium) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, such as pain from headaches, toothaches, muscle aches, or arthritis. It works by reducing inflammation and pain by blocking the production of certain chemicals (prostaglandins) in the body that cause inflammation.
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Frequently Asked Questions
How long does it take for Zipsor to start working?
Zipsor typically starts to relieve pain within 30 minutes to 1 hour after taking a dose.
Can I take Zipsor with other pain medications?
Zipsor should not be taken with other NSAIDs (such as ibuprofen or naproxen). However, it can generally be taken with acetaminophen (Tylenol), but always check with your healthcare provider.
What should I do if I miss a dose of Zipsor?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed dose.
Can Zipsor cause stomach ulcers?
Yes, Zipsor, like other NSAIDs, can increase the risk of stomach ulcers and gastrointestinal bleeding, especially with long-term use or at higher doses. Taking it with food or milk can help reduce this risk.
Is Zipsor safe for long-term use?
Zipsor is generally intended for short-term use to treat acute pain. Long-term use can increase the risk of gastrointestinal, cardiovascular, kidney, and liver complications. Always follow your healthcare provider’s instructions on the duration of treatment.
Comprehensive Drug Guide
How Does Zipsor Work?
Zipsor works by inhibiting the cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins. Prostaglandins play a key role in causing inflammation, pain, and fever. By reducing their production, Zipsor helps relieve pain and decrease swelling.
Common Dosages
- 25 mg oral capsules
Typical Dosing
- The typical dose of Zipsor for adults is 25 mg four times daily. It should be taken with or without food, but taking it with food may reduce gastrointestinal side effects.
Typical Dosing
FDA Approved Indications
- Relief of mild to moderate acute pain in adults.
Who Shouldn't Take Zipsor?
- History of allergic reactions to aspirin or other NSAIDs (e.g., hives, swelling, asthma attacks)
- Active gastrointestinal bleeding or ulcers
- Severe kidney or liver disease
- Coronary artery bypass graft (CABG) surgery, as NSAIDs increase the risk of heart attack and stroke following surgery
Advice From The Pharmacist
- Take Zipsor exactly as prescribed, and do not exceed the recommended dose, as it may increase the risk of serious side effects like gastrointestinal bleeding or cardiovascular events.
- Take Zipsor with food or a glass of milk to minimize gastrointestinal discomfort.
- Avoid alcohol while taking Zipsor, as it can increase the risk of stomach bleeding.
- Do not use Zipsor with other NSAIDs (e.g., ibuprofen, naproxen) unless instructed by your healthcare provider, as this can increase the risk of side effects.
Side Effects of Zipsor
Common Side Effects
- Nausea
- Stomach pain
- Indigestion
- Diarrhea
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding (black or bloody stools, vomiting blood)
- Heart attack or stroke
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Liver damage (yellowing of the skin or eyes, dark urine)
Risks and Warnings of Zipsor
- Gastrointestinal Risk: Zipsor can cause serious gastrointestinal side effects, including bleeding, ulcers, and perforation of the stomach or intestines. These risks are higher in older adults and people with a history of ulcers or gastrointestinal bleeding.
- Cardiovascular Risk: Zipsor can increase the risk of heart attack or stroke, especially if used long-term or in high doses. Patients with cardiovascular disease or risk factors for heart disease should use caution.
- Kidney and Liver Damage: Prolonged use of NSAIDs like Zipsor can lead to kidney or liver damage. Regular monitoring of kidney and liver function is recommended, especially in patients with preexisting conditions.
Interactions with Zipsor
Common Drug Interactions
- Other NSAIDs: Combining Zipsor with other NSAIDs (e.g., ibuprofen, naproxen) increases the risk of gastrointestinal bleeding and kidney damage.
- Anticoagulants (blood thinners): Zipsor can increase the risk of bleeding when used with blood thinners like warfarin.
- ACE inhibitors and diuretics: Zipsor may reduce the effectiveness of medications used to treat high blood pressure and heart failure.
Alternatives to Zipsor
- Ibuprofen (Advil, Motrin): Another NSAID commonly used for pain relief.
- Naproxen (Aleve): A longer-acting NSAID used to treat pain and inflammation.
- Acetaminophen (Tylenol): An alternative pain reliever that is not an NSAID and does not have the same gastrointestinal or cardiovascular risks.
