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Xepi
Xepi (ozenoxacin) is a topical antibiotic used to treat impetigo, a bacterial skin infection commonly caused by Staphylococcus aureus or Streptococcus pyogenes. Impetigo is a contagious skin condition that often affects young children, but it can also occur in adults. Xepi works by inhibiting bacterial DNA synthesis, which helps stop the infection from spreading and allows the skin to heal. It is particularly effective against strains of bacteria that are resistant to other antibiotics.
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Frequently Asked Questions
How long does it take for Xepi to start working?
Xepi typically begins to show improvement within a few days of starting treatment. However, you should complete the full 5-day course to ensure that the infection is fully resolved.
Can Xepi be used in children?
Yes, Xepi is approved for use in children aged 2 months and older for the treatment of impetigo caused by susceptible bacteria.
Can I use Xepi on large areas of skin?
Xepi is typically applied to small, affected areas of skin. If you have a larger area of infection or are unsure of how much to apply, consult your healthcare provider for guidance.
What should I do if I miss a dose of Xepi?
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Can Xepi be used to treat other skin infections?
Xepi is specifically indicated for impetigo and may not be effective against other types of skin infections. Consult your healthcare provider if you have another skin condition.
Comprehensive Drug Guide
How Does Xepi Work?
Xepi works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for bacterial DNA replication and repair. By blocking these enzymes, Xepi prevents the bacteria from multiplying, leading to the resolution of the infection.
Common Dosages
- Apply a thin layer to the affected area twice daily for 5 days. Xepi is for external use only.
Typical Dosing
- For impetigo: Apply a thin layer of Xepi cream to the affected area twice daily for a total of 5 days. Wash your hands before and after applying the cream, and avoid contact with the eyes or mouth.
Typical Dosing
FDA Approved Indications
- Impetigo caused by Staphylococcus aureus (including MRSA) and Streptococcus pyogenes in adults and children aged 2 months and older.
Who Shouldn't Take Xepi?
- Known hypersensitivity to ozenoxacin or any component of the formulation.
- It should not be used in cases of viral or fungal skin infections, as it is only effective against bacterial infections.
Advice From The Pharmacist
- Xepi is for external use only. Apply a thin layer of cream to the affected area twice daily, and gently rub it in.
- Do not use Xepi in or near the eyes, mouth, or vaginal area. If it accidentally comes into contact with these areas, rinse thoroughly with water.
- Complete the full 5-day treatment course, even if symptoms improve early, to prevent the infection from coming back.
- Avoid covering the treated area with tight dressings or bandages unless instructed by your healthcare provider.
- If you do not see improvement after 5 days, consult your healthcare provider for further evaluation.
Side Effects of Xepi
Common Side Effects
- Application site reactions, such as redness or irritation
- Itching or burning at the application site
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling, rash, hives, difficulty breathing)
- Worsening of the infection (if not used correctly)
Risks and Warnings of Xepi
- Allergic Reactions: Some patients may develop an allergic reaction to Xepi, including swelling or severe rash. Discontinue use immediately and seek medical attention if you experience signs of an allergic reaction.
- Bacterial Resistance: As with all antibiotics, using Xepi improperly or for an insufficient duration can contribute to the development of bacterial resistance. Be sure to use it only as directed.
Interactions with Xepi
Common Drug Interactions
- There are no significant systemic drug interactions with Xepi due to its topical application. However, inform your healthcare provider about any other medications or topical treatments you are using to ensure compatibility.
Alternatives to Xepi
- Mupirocin (Bactroban): Another topical antibiotic commonly used to treat impetigo and other minor skin infections caused by bacteria.
- Retapamulin (Altabax): A topical antibiotic used for impetigo and other bacterial skin infections.
- Oral antibiotics: In more severe cases of impetigo, oral antibiotics such as cephalexin or clindamycin may be prescribed.
