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Tobramycin-Dexamethasone
Tobramycin-Dexamethasone is a combination medication that contains tobramycin, an aminoglycoside antibiotic, and dexamethasone, a corticosteroid. It is used to treat bacterial eye infections and reduce associated inflammation. Tobramycin works by killing the bacteria that cause infection, while dexamethasone helps reduce redness, swelling, and discomfort. This combination is often used for conditions such as bacterial conjunctivitis and to manage inflammation after eye surgery.
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Frequently Asked Questions
How long does it take for Tobramycin-Dexamethasone to work?
You may notice improvement in symptoms within 1 to 2 days of starting treatment, but it's important to continue using the medication for the full prescribed duration to ensure complete resolution of the infection.
Can Tobramycin-Dexamethasone be used for viral eye infections?
No, Tobramycin-Dexamethasone is specifically used for bacterial eye infections. It is not effective against viral or fungal infections and should not be used for those conditions.
What should I do if I miss a dose of Tobramycin-Dexamethasone?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Can Tobramycin-Dexamethasone cause blurry vision?
Yes, temporary blurred vision is a common side effect immediately after applying the eye drops or ointment. This usually resolves within a few minutes.
How long should I use Tobramycin-Dexamethasone?
Tobramycin-Dexamethasone should generally not be used for longer than 2 weeks, unless directed by your healthcare provider. Prolonged use increases the risk of side effects such as glaucoma and cataracts.
Comprehensive Drug Guide
How Does Tobramycin-Dexamethasone Work?
Tobramycin works by inhibiting bacterial protein synthesis, effectively killing the bacteria that cause eye infections. Dexamethasone reduces inflammation by suppressing the immune response, alleviating symptoms such as swelling, redness, and irritation.
Common Dosages
- Ophthalmic suspension (eye drops): 0.3% tobramycin and 0.1% dexamethasone
- Ophthalmic ointment: 0.3% tobramycin and 0.1% dexamethasone
Typical Dosing
- For bacterial infections and inflammation: Apply one or two drops of Tobramycin-Dexamethasone ophthalmic suspension in the affected eye(s) every 4 to 6 hours. For more severe infections, your doctor may recommend using it every 2 hours initially, then reducing the frequency as the infection improves. The ointment is typically applied 2 to 3 times a day or as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Bacterial infections of the eye, such as bacterial conjunctivitis
- Post-surgical inflammation following eye surgery
- Inflammation associated with bacterial infections of the eye
Who Shouldn't Take Tobramycin-Dexamethasone?
- Viral, fungal, or mycobacterial eye infections, such as herpes simplex or tuberculosis
- Known hypersensitivity to tobramycin, dexamethasone, or any other components of the formulation
Advice From The Pharmacist
- Shake the suspension well before each use to ensure even distribution of the medication.
- Do not wear contact lenses while using Tobramycin-Dexamethasone, as they can worsen the infection or irritation.
- Do not touch the dropper tip to your eye or any surface to avoid contamination.
- Complete the full course of the medication, even if your symptoms improve early, to ensure the infection is fully treated and prevent recurrence.
Side Effects of Tobramycin-Dexamethasone
Common Side Effects
- Temporary blurred vision after application
- Eye redness or irritation
- Eye discomfort or itching
- Increased tearing or watery eyes
Uncommon/Severe Side Effects
- Increased intraocular pressure (IOP)
- Glaucoma or optic nerve damage (with prolonged use)
- Cataract formation (with long-term use)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Tobramycin-Dexamethasone
- Increased Intraocular Pressure: Long-term use of corticosteroids like dexamethasone may increase IOP, which can lead to glaucoma or optic nerve damage. Regular monitoring of eye pressure is recommended during extended treatment.
- Infection Risk: Dexamethasone may mask or worsen symptoms of non-bacterial infections (e.g., viral or fungal). Stop using the medication and consult your healthcare provider if your symptoms worsen.
- Cataract Formation: Prolonged use of corticosteroids can increase the risk of cataracts. Regular eye examinations are recommended for those using the medication over long periods.
Interactions with Tobramycin-Dexamethasone
Common Drug Interactions
- Other corticosteroid-containing products: Using additional corticosteroids alongside Tobramycin-Dexamethasone may increase the risk of side effects such as glaucoma or cataracts.
- NSAIDs: Combining this medication with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of corneal ulcers or other complications.
Alternatives to Tobramycin-Dexamethasone
- Maxitrol (neomycin, polymyxin B, dexamethasone): Another combination of antibiotic and corticosteroid for treating bacterial eye infections.
- Vigamox (moxifloxacin): A fluoroquinolone antibiotic used for bacterial infections of the eye, without a corticosteroid component.
- Prednisolone acetate: A corticosteroid eye drop used for reducing inflammation in the eye.
