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Tivorbex

Tivorbex (generic name: indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and bursitis. It helps reduce pain and inflammation by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain. Tivorbex is typically prescribed for short-term management of pain, particularly after an injury or surgery.



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Frequently Asked Questions

How long does it take for Tivorbex to start working?
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Tivorbex typically begins working within 30 to 60 minutes after taking a dose, with peak effects occurring after about 1 to 2 hours.

Can Tivorbex be taken long-term?
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While Tivorbex can be effective for managing pain, long-term use increases the risk of serious side effects such as gastrointestinal bleeding, heart attack, and kidney damage. It is generally recommended for short-term use unless advised otherwise by your doctor.

What should I do if I miss a dose of Tivorbex?
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If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Can I take Tivorbex with other pain relievers?
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You should avoid taking Tivorbex with other NSAIDs, such as ibuprofen or aspirin, as this increases the risk of gastrointestinal bleeding. Talk to your healthcare provider before combining pain relievers.

Is Tivorbex safe to use during pregnancy?
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Tivorbex is generally not recommended during pregnancy, especially in the third trimester, as it may affect the development of the fetus. Always consult your healthcare provider before taking this medication if you are pregnant or planning to become pregnant.

Comprehensive Drug Guide

How Does Tivorbex Work?

Tivorbex works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the synthesis of prostaglandins, chemicals that promote inflammation, pain, and fever. By reducing prostaglandin production, Tivorbex helps decrease inflammation and pain.



Common Dosages

  • 20 mg oral capsules
  • 40 mg oral capsules

Typical Dosing

  • The typical dose of Tivorbex is 20 mg to 40 mg, taken 2 to 3 times daily as needed for pain relief. Dosing may be adjusted based on the severity of the pain and the patient’s response to the treatment.


Typical Dosing

FDA Approved Indications

  • Mild to moderate acute pain in adults, including pain from osteoarthritis, rheumatoid arthritis, and other inflammatory conditions.


Who Shouldn't Take Tivorbex?

  • Active gastrointestinal bleeding or ulcers
  • Severe kidney or liver impairment
  • Known hypersensitivity to indomethacin or other NSAIDs
  • Asthma or allergic reactions triggered by NSAIDs or aspirin


Advice From The Pharmacist

  • Take Tivorbex with food or milk to reduce the risk of stomach upset or irritation.
  • Do not take Tivorbex with other NSAIDs, such as ibuprofen or aspirin, as this may increase the risk of gastrointestinal bleeding.
  • Stay hydrated and avoid excessive alcohol consumption while taking Tivorbex, as it can increase the risk of stomach bleeding and kidney issues.
  • If you experience any signs of stomach pain, black or tarry stools, or unusual bleeding, contact your healthcare provider immediately.


Side Effects of Tivorbex

Common Side Effects

  • Nausea or vomiting
  • Stomach pain
  • Diarrhea
  • Headache
  • Dizziness


Uncommon/Severe Side Effects

  • Gastrointestinal bleeding or ulcers
  • Kidney damage
  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Heart attack or stroke (especially with long-term use)

Risks and Warnings of Tivorbex

  • Gastrointestinal Risk: Tivorbex can increase the risk of serious gastrointestinal issues such as bleeding, ulcers, or perforation, especially in patients with a history of GI conditions or those taking it long-term.
  • Cardiovascular Risk: NSAIDs, including Tivorbex, may increase the risk of serious cardiovascular events such as heart attack or stroke, particularly in patients with existing heart conditions or those using the medication for extended periods.
  • Kidney Damage: Long-term use of Tivorbex may cause kidney damage, especially in individuals with pre-existing kidney conditions or those taking other medications that affect kidney function.


Interactions with Tivorbex

Common Drug Interactions

  • Anticoagulants (e.g., warfarin): Tivorbex can increase the risk of bleeding when taken with blood thinners.
  • ACE inhibitors and ARBs: Tivorbex may reduce the effectiveness of blood pressure medications, such as ACE inhibitors or angiotensin receptor blockers.
  • Corticosteroids: Using Tivorbex with corticosteroids increases the risk of gastrointestinal side effects, including bleeding.
  • Diuretics: Tivorbex may reduce the effectiveness of diuretics and increase the risk of kidney damage.


Alternatives to Tivorbex

  • Ibuprofen (Advil, Motrin): Another NSAID used to treat pain and inflammation, available over the counter.
  • Naproxen (Aleve): A long-acting NSAID used to treat pain, inflammation, and arthritis.
  • Celecoxib (Celebrex): A COX-2 inhibitor NSAID that may have a lower risk of gastrointestinal side effects compared to traditional NSAIDs.
  • Acetaminophen (Tylenol): An analgesic and antipyretic used for pain relief without the anti-inflammatory effects of NSAIDs.