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Theophylline
Theophylline is a bronchodilator, which is a fancy way of saying it helps to ease the tightness in your chest, wheezing, and difficulty breathing that can come with conditions like asthma and chronic obstructive pulmonary disease (COPD).
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Frequently Asked Questions
Are there any specific concerns for longterm use?
Longterm use of Theophylline should be monitored closely by your physician to ensure effective and safe dosage levels. Regular checkups are essential.
Can I just stop taking Theophylline after my symptoms are gone?
No, you should not stop taking Theophylline without consulting your doctor as sudden discontinuation can exacerbate your symptoms.
Does Theophylline have any food or drink restrictions?
Yes, it's recommended to avoid large amounts of caffeinecontaining food or beverages while taking Theophylline as it can increase side effects.
Is Theophylline safe to use during pregnancy or while breastfeeding?
It's categorized as a Category C drug for pregnancy, which means potential benefits should outweigh potential risks. It's suggested to use it with caution while breastfeeding.
What are the signs of a Theophylline overdose?
Possible signs of an overdose may include nausea, vomiting, insomnia, restlessness, seizure, cardiac arrhythmias, and even cardiac arrest. Seek immediate medical attention if you suspect an overdose.?
What should I do if I miss a dose of Theophylline?
Take the missed dose as soon as you remember unless it's closer to the time for your next dose. In that case, skip the missed dose. Do not double doses.
Comprehensive Drug Guide
How Does Theophylline Work?
Theophylline works by relaxing and opening air passages in the lungs, which, in turn, increases the flow of air. Essentially, this drug stimulates the central nervous system, cardiovascular system, and respiratory center and dilates systemic blood ves
What is Theophylline Used For?
FDA Indications: Asthma, COPD.
Offlabel uses: Apnea of Prematurity.
Common Dosages
Tablets: 100mg, 200mg, 300mg, 400mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Asthma: 10 mg/kg/day for patients under 45kg. 400 mg/day for patients over 45kg.
- COPD: 10 mg/kg/day for patients under 45kg. 400 mg/day for patients over 45kg.
Who Shouldn't Take Theophylline?
- Are allergic to theophylline or other drugs like it.
- Have a history of active peptic ulcer disease.
- Have been diagnosed with seizure disorders.
- Have certain heart conditions like rapid or irregular heartbeat.
Advice From The Pharmacist
- Take this medication at the same time each day.
- Avoid drinking or eating large amounts of foods and drinks that contain caffeine. It can worsen the side effects.
- Make sure you ??re not in a smoking environment as nicotine can decrease the effectiveness of theophylline.
- If you're feeling extra jittery or restless, let your doctor know. Theophylline can affect your nervous system.
- Got a fever or signs of a new illness? Tell your doctor. These may require a dosage modification.
Side Effects of Theophylline
Common Side Effects
- Headache
- Trouble sleeping
- Irritability
- Restlessness
- Nausea or Vomiting
Uncommon/Severe Side Effects
- Severe side effects:
- Seizures
- Lightheadedness or fainting
- Confusion
- Rash
- Tremors
Risks and Warnings of Theophylline
- Active peptic ulcer disease
- Seizure disorders
- Cardiac arrhythmias, especially supraventricular tachyarrhythmias
- Acute myocardial injury
- Concurrent use with certain CYP450 1A2 and 3A4 inhibitors
Interactions with Theophylline
Common Drug Interactions
- Cimetidine
- Erythromycin
- Clarithromycin
- Allopurinol
- Ciprofloxacin
Alternatives to Theophylline
- Longacting betaagonists
- Inhaled corticosteroids
- Anticholinergics
- Leukotriene modifiers
