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Tezspire
Tezspire (generic name: tezepelumab-ekko) is an injectable biologic medication used for the treatment of severe asthma in adults and adolescents aged 12 and older. It is indicated for patients whose asthma is not well controlled with other treatments, such as inhaled corticosteroids. Tezspire is a monoclonal antibody that works by blocking thymic stromal lymphopoietin (TSLP), a molecule that plays a key role in inflammation. By targeting TSLP, Tezspire helps reduce asthma exacerbations and improve lung function.
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Frequently Asked Questions
How long does it take for Tezspire to work?
Tezspire may begin to improve asthma symptoms within a few weeks, but full benefits may take several months. Regular injections are necessary for long-term asthma control.
Can I administer Tezspire myself at home?
No, Tezspire is usually administered by a healthcare professional in a clinic or hospital setting. Discuss with your healthcare provider if you have concerns about administration.
Will Tezspire replace my other asthma medications?
Tezspire is used in combination with other asthma treatments, such as inhaled corticosteroids. Do not stop using your other asthma medications unless advised by your doctor.
Can I stop using Tezspire if my asthma improves?
No, do not stop using Tezspire without consulting your doctor. Discontinuing treatment may lead to worsening asthma symptoms or more frequent exacerbations.
What should I do if I miss a dose of Tezspire?
If you miss a dose, contact your healthcare provider to schedule the next injection as soon as possible. Do not wait until the next scheduled dose to resume treatment.
Comprehensive Drug Guide
How Does Tezspire Work?
Tezspire works by inhibiting the activity of TSLP, a cytokine involved in triggering immune responses that lead to airway inflammation in asthma. By blocking TSLP, Tezspire helps reduce the activation of multiple inflammatory pathways, lowering the risk of asthma attacks and improving overall asthma control.
Common Dosages
Tezspire is available as a 210 mg/1.91 mL solution in a pre-filled syringe for subcutaneous injection.
Typical Dosing
- For severe asthma: The typical dose is 210 mg injected subcutaneously once every 4 weeks. The injections are usually administered by a healthcare professional.
Typical Dosing
FDA Approved Indications
- Severe asthma in adults and adolescents (12 years and older) whose asthma is not adequately controlled with standard therapies, such as inhaled corticosteroids.
Who Shouldn't Take Tezspire?
- Known hypersensitivity to tezepelumab or any of the components of the formulation
- Acute asthma attacks or as a rescue medication for sudden breathing problems
Advice From The Pharmacist
- Tezspire is administered once every 4 weeks by a healthcare provider, usually through a subcutaneous injection in the thigh, abdomen, or upper arm.
- Continue using your other asthma medications as prescribed, even while on Tezspire, unless your doctor advises otherwise.
- Monitor for allergic reactions, such as rash, swelling, or difficulty breathing, and inform your healthcare provider if these occur.
- Tezspire does not provide immediate relief for asthma attacks. Keep a rescue inhaler on hand for sudden asthma symptoms.
- Store Tezspire in the refrigerator until use. Allow it to reach room temperature for 30 minutes before injecting.
Side Effects of Tezspire
Common Side Effects
- Sore throat
- Back pain
- Injection site reactions (redness, swelling, pain)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Increased risk of infections
Risks and Warnings of Tezspire
- Allergic Reactions: Although rare, severe allergic reactions (anaphylaxis) can occur with Tezspire. Patients should be monitored for signs of an allergic reaction after the injection.
- Infection Risk: Tezspire may slightly increase the risk of infections. Patients with a history of frequent infections or immunocompromised conditions should inform their healthcare provider before starting therapy.
Interactions with Tezspire
Common Drug Interactions
- Live vaccines: Avoid receiving live vaccines while on Tezspire, as it can interfere with the body’s immune response to these vaccines.
- Other biologic therapies: Caution is advised when combining Tezspire with other biologics or immunosuppressive therapies, as this may increase the risk of side effects or reduce the effectiveness of treatment.
Alternatives to Tezspire
- Dupixent (dupilumab): Another biologic medication used to treat moderate-to-severe asthma by inhibiting IL-4 and IL-13 signaling pathways.
- Xolair (omalizumab): A monoclonal antibody targeting IgE, used for severe allergic asthma.
- Fasenra (benralizumab): A biologic that targets IL-5 and is used for the treatment of severe eosinophilic asthma.
- Nucala (mepolizumab): A biologic targeting IL-5, used for severe eosinophilic asthma.
