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Nucala
Nucala (generic name: mepolizumab) is a monoclonal antibody used for the treatment of severe asthma and certain other eosinophilic conditions, such as eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilia. It is designed to target and inhibit interleukin-5 (IL-5), a cytokine involved in the growth and activation of eosinophils, which are white blood cells that contribute to inflammation and asthma symptoms.
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Frequently Asked Questions
How quickly does Nucala work?
Patients may begin to notice improvements in asthma control within 4 to 8 weeks of starting treatment.
Can I take Nucala with other asthma medications?
Yes, Nucala is intended to be used as an add-on treatment and can be taken alongside other asthma medications.
What should I do if I miss a dose?
If you miss a dose, administer it as soon as you remember. If it's close to the time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Nucala?
There are no specific dietary restrictions while using Nucala.
Comprehensive Drug Guide
How Does Nucala Work?
Mepolizumab works by binding to IL-5 and preventing it from interacting with its receptor on eosinophils. This action leads to a reduction in eosinophil levels in the blood and tissues, thereby decreasing inflammation and helping to control asthma symptoms.
Common Dosages
- Injection: 100 mg/mL in a single-dose prefilled syringe.
Typical Dosing
- The usual dosage for adults and children over 12 years old is 100 mg administered subcutaneously once every 4 weeks. For children aged 6 to 11 years, the dosage may be adjusted based on weight.
Typical Dosing
FDA Approved Indications
- Severe Asthma: as an add-on maintenance treatment for patients aged 6 years and older with severe asthma characterized by eosinophilic phenotype.
- Eosinophilic Granulomatosis with Polyangiitis (EGPA): as a treatment for adult patients.
- Hypereosinophilia: for the treatment of patients with a history of hypereosinophilia.
Who Shouldn't Take Nucala?
- Known hypersensitivity to mepolizumab or any component of the formulation.
- Acute asthma exacerbations; it is not intended for the treatment of sudden asthma attacks.
Advice From The Pharmacist
- Nucala is administered by subcutaneous injection; patients can be trained to self-administer or may receive it in a healthcare setting.
- Monitor for any signs of allergic reactions after the injection, especially during the first dose.
- Continue taking other asthma medications as prescribed, even while using Nucala.
Side Effects of Nucala
Common Side Effects
- Injection site reactions (redness, swelling, itching)
- Headache
- Fatigue
- Back pain
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Signs of infection (fever, chills).
Risks and Warnings of Nucala
- Infection Risk: Mepolizumab may increase the risk of infections due to eosinophil depletion; monitor for signs of infection.
- Allergic Reactions: Be vigilant for signs of an allergic reaction, particularly after the first injection.
Interactions with Nucala
Common Drug Interactions
- Other Immunosuppressive Therapies: Use caution when combined with other medications that may affect immune function.
Alternatives to Nucala
- Other Biologic Therapies: Such as dupilumab or benralizumab for asthma management.
- Standard Asthma Treatments: Including inhaled corticosteroids or other systemic medications.
