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Dupixent
Dupixent (dupilumab) is a monoclonal antibody used to treat several chronic inflammatory conditions including moderate to severe atopic dermatitis (eczema), asthma, and chronic rhinosinusitis with nasal polyps. It works by targeting and inhibiting interleukin-4 (IL-4) and interleukin-13 (IL-13), proteins involved in the inflammatory response. By blocking these pathways, Dupixent helps to reduce inflammation, manage symptoms, and improve the quality of life for patients with these chronic conditions.
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Frequently Asked Questions
How long does it take for Dupixent to start working?
Patients may start to see improvement in symptoms within 2 to 4 weeks of starting Dupixent, but full effects may take several months.
Can Dupixent cure eczema or asthma?
No, Dupixent does not cure eczema or asthma, but it helps manage symptoms by reducing inflammation. Long-term treatment may be necessary to keep symptoms under control.
What should I do if I miss a dose of Dupixent?
If you miss a dose, take it as soon as possible. If it's close to your next scheduled dose, skip the missed dose and take the next one at your regular time. Do not double up on doses.
Is Dupixent safe for children?
Yes, Dupixent is approved for children aged 6 months and older with moderate to severe atopic dermatitis and 6 years and older for asthma. Pediatric dosing will vary based on the child’s weight and condition.
Can I stop using Dupixent if my symptoms improve?
You should continue using Dupixent as prescribed, even if your symptoms improve, to maintain control of your condition. Always consult your healthcare provider before discontinuing the medication.
Comprehensive Drug Guide
How Does Dupixent Work?
Dupixent works by inhibiting the signaling of interleukin-4 (IL-4) and interleukin-13 (IL-13), two key cytokines that contribute to chronic inflammation in conditions like atopic dermatitis, asthma, and chronic rhinosinusitis. By blocking these signals, Dupixent helps reduce inflammation, relieve symptoms such as itching and skin lesions in eczema, improve lung function in asthma, and decrease nasal congestion in patients with nasal polyps.
Common Dosages
Dupixent is available in the following forms and strengths:
- Pre-filled syringes or pens: 200 mg/1.14 mL, 300 mg/2 mL
Typical Dosing
- For atopic dermatitis: The initial dose is 600 mg (two 300 mg injections), followed by 300 mg every other week.
- For asthma: The typical dose is 400 mg initially (two 200 mg injections), followed by 200 mg every other week. In severe cases, 600 mg initially, followed by 300 mg every other week.
- For nasal polyps: The typical dose is 300 mg every other week.
Typical Dosing
FDA Approved Indications
- Moderate to severe atopic dermatitis (eczema) in adults and children aged 6 months and older
- Moderate to severe asthma in patients aged 6 years and older
- Chronic rhinosinusitis with nasal polyps in adults
Who Shouldn't Take Dupixent?
- Known hypersensitivity to dupilumab or any component of the formulation
- Active parasitic infections
Advice From The Pharmacist
- Dupixent is administered via subcutaneous injection, typically in the thigh, abdomen, or upper arm. Patients can self-administer after receiving proper training.
- Store Dupixent in the refrigerator and allow it to reach room temperature (30-45 minutes) before injecting. Do not shake the syringe or pen.
- Continue using Dupixent as prescribed, even if symptoms improve, to maintain control of the condition.
- If you experience any severe allergic reactions or unusual symptoms, contact your healthcare provider immediately.
Side Effects of Dupixent
Common Side Effects
- Injection site reactions (redness, swelling, pain)
- Eye problems (conjunctivitis, dry eyes)
- Cold sores (herpes simplex infection)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis, swelling of the face or throat)
- Eye inflammation (new or worsening eye problems, vision changes)
Risks and Warnings of Dupixent
- Allergic Reactions: Dupixent may cause serious allergic reactions, including anaphylaxis. Discontinue use if severe reactions occur and seek immediate medical attention.
- Eye Problems: Dupixent has been associated with new or worsening eye problems, including conjunctivitis and keratitis. Report any vision changes or eye discomfort to your doctor.
- Parasitic Infections: Dupixent may increase the risk of parasitic infections. Patients in areas where these infections are common should be monitored closely.
Interactions with Dupixent
Common Drug Interactions
- Live vaccines: Avoid live vaccines while using Dupixent, as it may reduce the body's ability to fight the vaccine.
- Immunosuppressants: Combining Dupixent with other immunosuppressants may increase the risk of infections or reduce the effectiveness of the treatment.
Alternatives to Dupixent
- Adbry (tralokinumab): A monoclonal antibody used to treat atopic dermatitis by targeting IL-13.
- Xolair (omalizumab): Used for asthma and chronic hives, working by targeting IgE antibodies.
- Dupixent biosimilars (future alternatives): Biosimilar versions of Dupixent are being developed and may offer cost-effective alternatives in the future.
