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Adbry
Adbry (generic name: tralokinumab-ldrm) is a biologic medication used for the treatment of moderate to severe atopic dermatitis (eczema) in adults. It is a monoclonal antibody that specifically targets interleukin-13 (IL-13), a cytokine that plays a key role in the inflammatory process associated with atopic dermatitis. By blocking IL-13, Adbry helps reduce inflammation, itching, and skin lesions associated with eczema, improving the overall skin condition of patients who do not respond well to topical treatments alone.
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Frequently Asked Questions
How long does it take for Adbry to work?
Some patients begin to see improvement in their eczema symptoms within a few weeks, but full effects may take up to 16 weeks.
Can I take Adbry with other eczema treatments?
Yes, Adbry can be used with topical corticosteroids or moisturizers to help manage symptoms, but avoid combining it with other systemic biologics unless directed by your healthcare provider.
Is Adbry safe for long-term use?
Adbry has been shown to be safe for long-term use in clinical trials, but regular monitoring by a healthcare provider is important to ensure continued effectiveness and safety.
Can Adbry be used during pregnancy?
The safety of Adbry during pregnancy has not been fully established. Consult your healthcare provider before using Adbry if you are pregnant or planning to become pregnant.
What should I do if I miss a dose of Adbry?
If you miss a dose, take it as soon as you remember, but skip the missed dose if it is close to your next scheduled dose. Do not take extra doses to make up for the missed one.
Comprehensive Drug Guide
How Does Adbry Work?
Adbry works by blocking IL-13, a key cytokine involved in the immune response that causes the symptoms of atopic dermatitis. IL-13 contributes to the inflammation, itching, and damage seen in eczema. By inhibiting this cytokine, Adbry helps to reduce the immune response, allowing the skin to heal, while also decreasing the frequency and severity of eczema flare-ups.
Common Dosages
- Pre-filled syringes: 150 mg tralokinumab
Typical Dosing
- The recommended starting dose of Adbry is 600 mg (four 150 mg injections), followed by 300 mg (two injections) every two weeks.
- Some patients who achieve well-controlled symptoms may transition to 300 mg every four weeks, depending on their healthcare provider's assessment.
Typical Dosing
FDA Approved Indications
- The treatment of moderate to severe atopic dermatitis (eczema) in adults who are candidates for systemic therapy (such as biologics or other immune-modulating medications).
Who Shouldn't Take Adbry?
- Known hypersensitivity to tralokinumab or any of the ingredients in the formulation.
Advice From The Pharmacist
- Adbry should be stored in the refrigerator and brought to room temperature (about 30 minutes) before injection.
- Rotate injection sites between the abdomen, thigh, or upper arm to reduce the risk of irritation.
- Patients should avoid using Adbry during active infections, as it may lower the body’s ability to fight infections.
- Do not discontinue the medication without consulting your healthcare provider, even if symptoms improve.
Side Effects of Adbry
Common Side Effects
- Injection site reactions (pain, redness, swelling)
- Upper respiratory tract infections
- Eye irritation or conjunctivitis
Uncommon/Severe Side Effects
- Severe allergic reactions (such as anaphylaxis)
- Serious infections
Risks and Warnings of Adbry
- Allergic Reactions: Adbry can cause serious allergic reactions, including anaphylaxis. If you experience difficulty breathing, swelling, or rash, seek emergency medical help immediately.
- Infections: Patients using Adbry may be at increased risk for infections. Notify your healthcare provider if you develop fever, chills, or signs of an infection while using the medication.
Interactions with Adbry
Common Drug Interactions
- Live vaccines: Avoid using live vaccines while on Adbry, as the medication may weaken the immune response to the vaccine, making it less effective.
- Other biologic medications: Combining Adbry with other immune-modulating biologics or systemic immunosuppressive therapies may increase the risk of infections or other complications.
Alternatives to Adbry
- Dupixent (dupilumab): Another biologic targeting IL-4 and IL-13, used for treating moderate to severe atopic dermatitis.
- Topical corticosteroids: Commonly used to manage mild to moderate eczema symptoms, although less effective for severe cases.
- Immunosuppressants: Oral medications like cyclosporine or methotrexate may be used for patients with severe eczema who do not respond to biologics or topical therapies.
