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Fasenra
Fasenra (generic name: benralizumab) is a monoclonal antibody used as an add-on maintenance treatment for patients with severe eosinophilic asthma. It targets interleukin-5 receptor alpha (IL-5Rα), which helps reduce eosinophils, a type of white blood cell involved in allergic asthma. Reducing eosinophils helps decrease asthma symptoms and flare-ups.
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Frequently Asked Questions
How long does it take for Fasenra to start working?
Some patients experience improvements in asthma symptoms after the first few doses, but full effects may take several months.
Can I stop my other asthma medications after starting Fasenra?
Do not stop your other asthma medications without consulting your healthcare provider. Fasenra is intended to be used as an add-on therapy.
How is Fasenra administered?
Fasenra is given as a subcutaneous injection by a healthcare provider, but some patients may be trained to self-administer using the Fasenra Pen.
Does Fasenra cure asthma?
No, Fasenra does not cure asthma, but it helps to reduce asthma symptoms and exacerbations in patients with eosinophilic asthma.
Can I receive vaccinations while taking Fasenra?
Inactivated vaccines are generally safe while taking Fasenra, but you should avoid live vaccines. Always consult your healthcare provider before receiving any vaccines.
Comprehensive Drug Guide
How Does Fasenra Work?
Fasenra binds to the IL-5 receptor alpha on eosinophils, a type of white blood cell involved in asthma-related inflammation. This leads to the destruction of eosinophils, reducing inflammation and helping to prevent asthma symptoms and exacerbations.
Common Dosages
- 30 mg/1 mL prefilled syringe or autoinjector for subcutaneous injection.
Typical Dosing
- The typical dosing for Fasenra is 30 mg administered once every 4 weeks for the first 3 doses, followed by once every 8 weeks thereafter.
Typical Dosing
FDA Approved Indications
- Severe eosinophilic asthma in patients aged 12 years and older as an add-on maintenance therapy
Who Shouldn't Take Fasenra?
- Known hypersensitivity to benralizumab or any other components of the formulation.
Advice From The Pharmacist
- Fasenra is administered by a healthcare provider as a subcutaneous injection. After initial doses, it may be possible for patients to self-administer at home with the Fasenra Pen, under the guidance of their healthcare provider.
- Report any signs of allergic reactions, such as rash, swelling, or difficulty breathing, to your healthcare provider immediately.
- Fasenra is not intended for relief of acute asthma symptoms or asthma attacks. Always keep your rescue inhaler on hand.
Side Effects of Fasenra
Common Side Effects
- Headache
- Sore throat
- Injection site reactions
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
Risks and Warnings of Fasenra
- Allergic Reactions: Although rare, Fasenra may cause severe allergic reactions, including anaphylaxis. Seek immediate medical attention if you experience symptoms of an allergic reaction.
- Parasitic Infections: Patients taking Fasenra may be more susceptible to parasitic infections, such as helminths. If you develop symptoms of infection, contact your healthcare provider.
Interactions with Fasenra
Common Drug Interactions
- No significant drug interactions have been identified with Fasenra, but it is important to inform your healthcare provider of all medications you are taking.
Alternatives to Fasenra
- Nucala (mepolizumab): Another monoclonal antibody that targets IL-5 for the treatment of eosinophilic asthma.
- Xolair (omalizumab): A monoclonal antibody used to treat allergic asthma and chronic hives.
- Dupixent (dupilumab): A monoclonal antibody used to treat asthma and other allergic conditions.
