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Fasenra Pen
Fasenra Pen (generic name: benralizumab) is a biologic medication used to treat severe asthma that is eosinophilic in nature. It is an interleukin-5 receptor antagonist that targets and reduces eosinophils, a type of white blood cell that plays a key role in asthma-related inflammation. Fasenra is used in combination with other asthma medications to reduce the frequency of asthma exacerbations and improve breathing in patients whose asthma is not well controlled with standard treatments. The Fasenra Pen is a self-administered subcutaneous injection designed for ease of use at home.
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Frequently Asked Questions
How long does it take for Fasenra to work?
Many patients start to notice improvements in their asthma symptoms within the first 4 to 6 weeks of treatment, but full benefits may take a few months to become evident.
Can I inject Fasenra Pen myself?
Yes, Fasenra Pen is designed for self-administration. Your healthcare provider will train you on how to use the pen correctly.
What should I do if I miss a dose of Fasenra?
If you miss a dose, inject it as soon as you remember. Then resume your regular dosing schedule, which is once every 8 weeks after the initial phase.
Is Fasenra a rescue medication?
No, Fasenra is not a rescue medication and should not be used to treat sudden asthma attacks. Always keep a rescue inhaler for acute asthma symptoms.
How is Fasenra different from other asthma medications?
Fasenra specifically targets eosinophilic asthma, which is a subtype of asthma driven by high levels of eosinophils. It works by reducing the number of eosinophils, helping to prevent inflammation and asthma exacerbations in this type of asthma.
Comprehensive Drug Guide
How Does Fasenra Pen Work?
Fasenra works by binding to the interleukin-5 (IL-5) receptor alpha on the surface of eosinophils. IL-5 is a key cytokine involved in the production, survival, and activation of eosinophils. By blocking the IL-5 receptor, Fasenra leads to the depletion of eosinophils, which reduces inflammation in the airways and helps to control severe eosinophilic asthma.
Common Dosages
The typical dosage for Fasenra Pen is:
- Initial dose: 30 mg injected once every 4 weeks for the first three doses.
- Maintenance dose: 30 mg injected once every 8 weeks after the initial loading phase.
Typical Dosing
- For severe eosinophilic asthma: The standard dosing schedule involves an initial phase of 30 mg once every 4 weeks for the first 3 doses, followed by a maintenance phase of 30 mg once every 8 weeks.
- The Fasenra Pen is designed for self-injection under the skin (subcutaneous) into the abdomen, thigh, or upper arm. It should not be injected into areas where the skin is tender, bruised, red, or hardened.
Typical Dosing
FDA Approved Indications
- Severe eosinophilic asthma: As an add-on maintenance treatment for patients aged 12 years and older who have severe asthma with an eosinophilic phenotype. It is not indicated for the treatment of acute asthma exacerbations.
Who Shouldn't Take Fasenra Pen?
- Known hypersensitivity to benralizumab or any components of the formulation.
- Acute asthma symptoms or exacerbations, as Fasenra is not a rescue medication.
Advice From The Pharmacist
- Learn how to properly inject Fasenra Pen before using it at home. Your healthcare provider will show you the correct injection technique.
- The Fasenra Pen should be stored in the refrigerator and allowed to come to room temperature for about 30 minutes before use. Do not shake the pen.
- Do not use the Fasenra Pen if the solution is cloudy, discolored, or contains particles.
- If you miss a dose, administer the dose as soon as you remember, and then resume the regular dosing schedule.
- Fasenra is not a rescue medication for sudden asthma attacks. Always keep a rescue inhaler (such as albuterol) available for emergencies.
Side Effects of Fasenra Pen
Common Side Effects
- Headache
- Sore throat
- Injection site reactions (redness, pain, or swelling)
- Fever
Uncommon/Severe Side Effects
- Hypersensitivity reactions: Such as rash, itching, difficulty breathing, and swelling of the face, lips, or tongue.
- Infections: Increased risk of respiratory infections, including colds, flu, and pneumonia.
Risks and Warnings of Fasenra Pen
- Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, can occur with Fasenra. Seek medical attention immediately if you experience symptoms such as difficulty breathing, rash, or swelling of the face or throat.
- Parasitic Infections: Patients with pre-existing parasitic infections should have these infections treated prior to starting Fasenra, as the medication may weaken the immune system’s response to such infections.
- Immunosuppression: Although rare, Fasenra may slightly increase the risk of infections, so patients should be monitored for signs of respiratory infections.
Interactions with Fasenra Pen
Common Drug Interactions
- Vaccinations: Live vaccines should be avoided while taking Fasenra, as it may weaken the body’s immune response to such vaccines.
- Fasenra does not have significant drug interactions with most asthma medications but should be used with caution in combination with other biologics or immunosuppressants.
Alternatives to Fasenra Pen
- Nucala (mepolizumab): Another IL-5 antagonist biologic used for severe eosinophilic asthma.
- Dupixent (dupilumab): A biologic that targets IL-4 and IL-13, used for asthma and other allergic conditions.
- Xolair (omalizumab): A biologic used for asthma related to allergies, particularly in patients with high IgE levels.
