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Synthroid
Synthroid, also known under its generic name Levothyroxine, is a prescription only medication that replaces or provides more of a hormone that is normally produced by the thyroid gland. This hormone, crucial for growth and metabolism, is often deficient in people with hypothyroidism (an underactive thyroid). Synthroid is part of the Thyroxine drug class.
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Frequently Asked Questions
Can I take Synthroid at night?
Yes, but always take it on an empty stomach. If you prefer taking it at night, make sure you haven't eaten for several hours before taking your dose.
Does Synthroid cause weight loss?
It can be a side effect, especially if your dose is too high. If you're experiencing weight loss, contact your doctor it might be a sign your dose needs adjusting.
I missed a dose of Synthroid, what should I do?
If it's close to your next dose, just skip the missed one. If it's not, take it as soon as you remember. But don't double up on doses!
What should I avoid while taking Synthroid?
Try to avoid consuming foods like walnuts, dietary fiber, and soy products too close to when you take your dose, as they can decrease the absorption of the medication.
Comprehensive Drug Guide
How Does Synthroid Work?
Synthroid is a synthetic form of thyroxine (T4), a hormone secreted by the follicular cells of the thyroid gland. It influences protein synthesis and increases your metabolic rate.
What is Synthroid Used For?
Synthroid is used to treat an underactive thyroid and certain types of goiters.
Typical Dosing
FDA Approved Indications
The starting dose, dose increments, and maintenance dose are individualized based on patient variables such as age, weight, cardiovascular status, concomitant medical conditions, including pregnancy, concomitant medications, the clinical response to therapy, and blood levels of thyroid-stimulating hormone (TSH).
Who Shouldn't Take Synthroid?
- Anyone with untreated subclinical or overt thyrotoxicosis, acute myocardial infarction, or uncorrected adrenal insufficiency should avoid Levothyroxine.
Advice From The Pharmacist
- Take it on an empty stomach, 30 minutes to 1 hour before breakfast.
- If you forget to take your dose, take it as soon as you remember if it is on the same day.
- Women on consistent doses of levothyroxine who become pregnant should increase their daily dose by approximately 20-30%.
- Periodic monitoring of TSH and total or free T4 is necessary, and the target TSH level is lower than the average population.
- Fertility may be impaired in women when serum TSH levels are above the normal range.
- Synthroid absorption can be affected by a wide variety of drugs.
- Restoration of normal thyroid hormone balance is beneficial or neutral for ischemic heart disease.
Side Effects of Synthroid
Common Side Effects
- Common side effects may include hair loss, increased appetite, weight changes, or symptoms of hyperthyroidism such as increased sweating, sensitivity to heat, mood swings, tiredness, or nervousness.
Uncommon/Severe Side Effects
- Severe abdominal pain, trouble breathing, skin rash, extreme tiredness, seizures, and swelling of the hands, ankles, or feet.
Risks and Warnings of Synthroid
- Risks: Overdosage or abrupt withdrawal after prolonged use may lead to an adrenal crisis. Overdosage can also lead to symptoms of hyperthyroidism, including heart palpitations and nervousness.
- Warnings: Synthroid should not be used for the treatment of obesity or weight loss. It should be used with caution in elderly patients and those with cardiovascular disorders.
Interactions with Synthroid
Common Drug Interactions
- Warfarin
- Digoxin
- Proton pump inhibitors (like omeprazole, esomeprazole)
- Antacids and bile acid sequestrants such as aluminum and magnesium hydroxides (found in certain antacids), Cholestyramine, and Colestipol.
- Amiodarone
- Selective serotonin reuptake inhibitors (SSRIs such as fluoxetine and sertraline)
Common Food Interactions
- Avoid high-fiber foods and calcium or iron supplements an hour before or after taking levothyroxine.
- Grapefruit juice may delay absorption and reduce its effectiveness.
Alternatives to Synthroid
- Armour Thyroid
- Liothyronine
- Thyroid desiccated
