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SymlinPen 120
SymlinPen 120 (generic name: pramlintide acetate) is an injectable medication used to help manage blood sugar levels in adults with type 1 and type 2 diabetes who use insulin. It is a synthetic analog of amylin, a hormone that works with insulin to regulate blood sugar. SymlinPen is used to improve postprandial (after-meal) blood sugar control in patients whose insulin therapy alone is not enough.
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Frequently Asked Questions
Can I use SymlinPen without insulin?
No, SymlinPen is meant to be used as an adjunct to insulin therapy. It should not be used in place of insulin.
How soon should I inject SymlinPen before eating?
SymlinPen should be injected immediately before meals to help control blood sugar after eating.
What should I do if I experience nausea while using SymlinPen?
Nausea is a common side effect, especially when starting SymlinPen. It usually subsides over time. If nausea is severe or persistent, contact your healthcare provider to discuss adjusting the dose.
Can SymlinPen cause weight loss?
Yes, because SymlinPen promotes satiety and reduces food intake, some patients may experience weight loss while using the medication.
What should I do if I miss a dose of SymlinPen?
If you miss a dose, skip the missed dose and inject your next scheduled dose before your next meal. Do not take extra doses to make up for the missed one.
Comprehensive Drug Guide
How Does SymlinPen 120 Work?
- Slowing gastric emptying, which delays the absorption of glucose from food.
- Suppressing glucagon secretion (a hormone that raises blood sugar), particularly after meals.
- Promoting satiety (the feeling of fullness), which can reduce food intake.
Common Dosages
- 60 mcg and 120 mcg per injection.
Typical Dosing
- For type 1 diabetes: The initial dose is 15 mcg before major meals, and the dose is gradually increased in 15 mcg increments to a maintenance dose of 30 mcg or 60 mcg before meals.
- For type 2 diabetes: The typical starting dose is 60 mcg before major meals. The dose can be increased to 120 mcg if tolerated.
- SymlinPen 120 can deliver either 60 mcg or 120 mcg per dose depending on patient needs.
Typical Dosing
FDA Approved Indications
- Adjunct treatment to insulin in patients with type 1 diabetes or type 2 diabetes who fail to achieve optimal glucose control despite optimal insulin therapy.
Who Shouldn't Take SymlinPen 120?
- Hypoglycemia unawareness: Patients who are unaware of or unable to detect low blood sugar should not use SymlinPen.
- Gastroparesis: Delayed stomach emptying (gastroparesis) is a contraindication because SymlinPen further slows gastric emptying.
- Known hypersensitivity to pramlintide or any of the components in the formulation.
Advice From The Pharmacist
- SymlinPen is used with insulin: Pramlintide is an adjunct to insulin therapy and should not be used in place of insulin.
- Inject SymlinPen before meals: Administer the injection subcutaneously in the abdomen or thigh immediately before eating.
- Reduce insulin dose: Your doctor may recommend reducing your mealtime insulin dose by 50% when starting SymlinPen to reduce the risk of hypoglycemia.
- Rotate injection sites: Change the injection site regularly to avoid irritation or tissue damage.
Side Effects of SymlinPen 120
Common Side Effects
- Nausea
- Vomiting
- Loss of appetite
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Severe hypoglycemia (low blood sugar), especially when used with insulin. Hypoglycemia symptoms include sweating, shakiness, confusion, or fainting.
- Allergic reactions: Rare but severe reactions like swelling, rash, or difficulty breathing may occur.
Risks and Warnings of SymlinPen 120
- Hypoglycemia Risk: SymlinPen increases the risk of severe hypoglycemia, particularly in patients with type 1 diabetes. This is especially true within 3 hours of injecting SymlinPen. Blood sugar monitoring is essential, and insulin doses may need to be reduced.
- Gastroparesis: Patients with gastroparesis or other disorders that delay gastric emptying should avoid SymlinPen, as it slows stomach emptying and can worsen symptoms.
- Nausea: Pramlintide can cause nausea, especially when treatment is initiated or when the dose is increased. It usually subsides as the body adjusts.
Interactions with SymlinPen 120
Common Drug Interactions
- Insulin: When used with insulin, SymlinPen may increase the risk of hypoglycemia. Mealtime insulin doses should be reduced.
- Oral medications: Because SymlinPen slows gastric emptying, it may affect the absorption of oral medications. Take oral medications at least 1 hour before or 2 hours after using SymlinPen.
- Gastrointestinal medications: Avoid medications that further slow gastric emptying (e.g., anticholinergics) when using SymlinPen.
Alternatives to SymlinPen 120
- Byetta (Exenatide): Another injectable medication used for blood sugar control in type 2 diabetes.
- Victoza (Liraglutide): A GLP-1 receptor agonist used for type 2 diabetes to control blood sugar.
- Humalog (Insulin Lispro): A rapid-acting insulin used to manage blood sugar levels at mealtimes.
- Ozempic (Semaglutide): A GLP-1 receptor agonist that helps lower blood sugar and can also help with weight management in type 2 diabetes.
