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Sprix
Sprix (generic name: ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term treatment of moderate to severe pain. It is often used in adults for managing pain following surgery or other medical conditions that require powerful pain relief. Sprix comes in a nasal spray form, allowing for rapid pain relief without the need for injections or oral medications. It works by reducing the production of prostaglandins, substances in the body that cause pain and inflammation.
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Frequently Asked Questions
How soon can I expect pain relief after using Sprix?
Pain relief usually begins within 30 minutes to an hour after using Sprix. The nasal spray formulation allows for rapid absorption and quick relief.
Can I use Sprix for chronic pain conditions?
No, Sprix is intended for short-term use (no longer than 5 days) due to the risk of serious side effects. It is not recommended for managing chronic pain.
What should I do if I miss a dose of Sprix?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Can I take Sprix if I am on blood thinners?
Using Sprix with blood thinners (like warfarin) can increase the risk of bleeding. Always consult your healthcare provider before combining these medications.
How should I store Sprix?
Store Sprix at room temperature and keep it away from moisture. Once you open the bottle, it should be discarded after 24 hours, even if medication remains inside.
Comprehensive Drug Guide
How Does Sprix Work?
Sprix works by inhibiting the enzyme cyclooxygenase (COX-1 and COX-2), which is responsible for the synthesis of prostaglandins. By blocking this enzyme, Sprix reduces inflammation, pain, and swelling in the body, providing relief for acute pain conditions.
Common Dosages
- Nasal spray: Each bottle delivers 15.75 mg of ketorolac per spray.
Typical Dosing
- The typical dose is one spray in each nostril every 6-8 hours, with a maximum of four doses in a 24-hour period. Treatment duration should not exceed 5 days, as prolonged use increases the risk of serious side effects such as gastrointestinal bleeding or kidney damage.
Typical Dosing
FDA Approved Indications
- Short-term management of moderate to severe pain, typically after surgeries or painful conditions that require strong pain relief.
It is not intended for chronic pain management or minor conditions due to its potential side effects.
Who Shouldn't Take Sprix?
- Active or recent gastrointestinal bleeding or peptic ulcers.
- Severe renal impairment or a history of kidney disease.
- Hypersensitivity to ketorolac or other NSAIDs.
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs.
- Use with other NSAIDs or during the perioperative period of coronary artery bypass graft (CABG) surgery.
Advice From The Pharmacist
- Use Sprix only as prescribed and for no longer than 5 days to minimize the risk of serious side effects.
- Avoid using other NSAIDs (like ibuprofen or aspirin) while taking Sprix, as this increases the risk of gastrointestinal issues.
- Do not lie down immediately after using the nasal spray to allow the medication to be fully absorbed.
- Keep the nasal spray bottle at room temperature and discard it after 24 hours of first use, even if medication remains in the bottle.
- Drink plenty of water while using Sprix, and monitor for any signs of gastrointestinal discomfort or unusual bleeding.
Side Effects of Sprix
Common Side Effects
- Nasal irritation or discomfort
- Nausea
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers
- Kidney damage or decreased kidney function
- Increased risk of cardiovascular events such as heart attack or stroke, especially with prolonged use.
- Severe allergic reactions such as anaphylaxis, swelling, or difficulty breathing.
Risks and Warnings of Sprix
- Gastrointestinal Risks: Sprix can cause serious gastrointestinal effects, including bleeding, ulceration, and perforation. These risks are higher in older adults and those with a history of ulcers.
- Renal Risks: Sprix may cause renal impairment, particularly in patients with pre-existing kidney issues. Monitor for signs of kidney problems such as decreased urine output or swelling.
- Cardiovascular Risks: NSAIDs, including Sprix, may increase the risk of heart attack or stroke, particularly in patients with pre-existing cardiovascular conditions.
- Bleeding Risk: As an NSAID, Sprix can interfere with blood clotting, increasing the risk of bleeding during surgery or in patients with clotting disorders.
Interactions with Sprix
Common Drug Interactions
- Other NSAIDs: Combining Sprix with other NSAIDs (e.g., ibuprofen, naproxen) increases the risk of gastrointestinal side effects.
- Anticoagulants: The use of blood thinners such as warfarin or heparin increases the risk of bleeding when taken with Sprix.
- SSRIs or SNRIs: Certain antidepressants may increase the risk of bleeding when combined with NSAIDs like Sprix.
- Diuretics: The effectiveness of diuretics may be reduced when used with Sprix, and this combination may increase the risk of kidney damage.
Alternatives to Sprix
- Toradol (injectable ketorolac): The injectable form of ketorolac used for short-term pain relief, typically in a hospital setting.
- Ibuprofen: A less potent NSAID, available over-the-counter, used for mild to moderate pain.
- Celebrex (celecoxib): A COX-2 selective NSAID that may have a lower risk of gastrointestinal side effects.
- Opioids: In some cases, opioids such as oxycodone or hydrocodone may be used for short-term management of severe pain when NSAIDs are not suitable.
