You're not logged in. Please log in to earn stock or Bitcoin rewards on your prescription purchase.
Skyrizi Pen
Skyrizi (generic name: risankizumab-rzaa) is a biologic medication used to treat moderate to severe plaque psoriasis and psoriatic arthritis in adults. It belongs to a class of medications known as interleukin-23 (IL-23) inhibitors, which work by targeting a specific protein involved in the inflammatory process. By blocking IL-23, Skyrizi helps reduce the symptoms of psoriasis and psoriatic arthritis, such as plaque formation, joint pain, and inflammation. Skyrizi is administered via a pre-filled pen for subcutaneous (under the skin) injection.
Rx. Enter your prescription
How would you like to get your prescription? Select an option
Pharmacy pickup
Select from 35,000 pharmacies
Free two-day delivery
Coming soon!
Find a pharmacy near you. Enter your ZIP code
Are you a member? Sign up or log in.
Members have saved
$NaN
using our savings card for instant savings.
Don't pay full retail price and miss out on potential savings. Try it now—you have nothing to lose!
NaNM
worth of Satoshi has been rewarded to our members.
Everyone who signs up enjoys the benefits of earning FREE Bitcoin with every purchase.
How much Bitcoin can you earn with Skyrizi Pen ?
The potential for Bitcoin rewards to increase and appreciate in value is a possibility to consider, which may occur over time.
See the value of your savings today
Today's Value
1 Bitcoin = $NaN
Bitcoin (BTC)
...
USD
$NaN
Adjust Bitcoin's potential value to see how much it could be worth
Potential Value
1 Bitcoin =
Bitcoin (BTC)
...
USD
$NaN
Frequently Asked Questions
How long does it take for Skyrizi to start working?
Most patients begin to see improvement in their symptoms after about 4 weeks, with maximum improvement usually seen around 12 weeks.
Can I self-inject Skyrizi at home?
Yes, after receiving proper training from a healthcare provider, you can self-inject Skyrizi at home using the pre-filled pen. Be sure to follow your doctor’s instructions for safe administration.
Can I take Skyrizi if I have an infection?
If you have an active infection, Skyrizi may not be safe to start or continue. Always consult your doctor if you develop any signs of infection while on Skyrizi.
Can Skyrizi be used for conditions other than psoriasis?
Yes, Skyrizi is also approved for the treatment of psoriatic arthritis. Research is ongoing to determine if it can be used for other autoimmune diseases.
What should I do if I miss a dose of Skyrizi?
If you miss a dose, take it as soon as possible and then resume your regular schedule. Do not double up doses to make up for a missed one.
Comprehensive Drug Guide
How Does Skyrizi Pen Work?
Skyrizi works by targeting and inhibiting interleukin-23 (IL-23), a cytokine that plays a critical role in the immune system’s inflammatory response. By blocking IL-23, Skyrizi reduces the overactive immune response that causes the inflammation and skin cell overgrowth associated with psoriasis and psoriatic arthritis.
Common Dosages
- 150 mg/mL of risankizumab solution for injection.
Typical Dosing
- For plaque psoriasis: The initial dose is 150 mg (one injection) at week 0, week 4, and then every 12 weeks thereafter.
- For psoriatic arthritis: The same dosing schedule is followed (150 mg at week 0, week 4, and every 12 weeks thereafter), though your healthcare provider may adjust the regimen based on your individual needs.
Typical Dosing
FDA Approved Indications
- Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Active psoriatic arthritis in adults, used alone or in combination with other treatments.
Who Shouldn't Take Skyrizi Pen?
- Known hypersensitivity to risankizumab or any component of the formulation.
- Active tuberculosis (TB) or other severe infections, unless treated or managed.
Advice From The Pharmacist
- Store the Skyrizi pen in the refrigerator and allow it to come to room temperature for about 30 minutes before injecting. Do not shake the pen.
- Rotate the injection sites (abdomen, thigh, or upper arm) to avoid skin irritation.
- If you miss a dose, take it as soon as you remember and resume your regular dosing schedule. However, do not take two doses at the same time.
- Before starting Skyrizi, your doctor may screen you for tuberculosis (TB) and other infections. Inform your doctor of any recent or chronic infections.
Side Effects of Skyrizi Pen
Common Side Effects
- Upper respiratory infections
- Fatigue
- Injection site reactions (redness, swelling, or pain)
- Headache
Uncommon/Severe Side Effects
- Serious allergic reactions (hives, swelling, difficulty breathing)
- Severe infections, including tuberculosis
- Lowered immune system function, making it harder to fight infections
Risks and Warnings of Skyrizi Pen
- Infection Risk: Skyrizi may increase the risk of infections, especially in patients with a history of chronic infections or who are immunocompromised. Monitor for signs of infections, such as fever, cough, or unusual fatigue, and report them to your doctor immediately.
- Hypersensitivity Reactions: Some patients may experience severe allergic reactions, such as anaphylaxis. If you notice signs of a serious allergic reaction, such as swelling, hives, or trouble breathing, seek immediate medical attention.
- Tuberculosis: Patients should be screened for tuberculosis before initiating treatment. If you have latent TB, your doctor will treat it before starting Skyrizi.
Interactions with Skyrizi Pen
Common Drug Interactions
- Immunosuppressive therapies: Using Skyrizi with other immunosuppressants (e.g., corticosteroids or other biologics) may increase the risk of infections or other immune-related side effects.
- Live vaccines: Avoid receiving live vaccines while on Skyrizi, as the medication may weaken the body’s ability to handle live virus vaccines.
Alternatives to Skyrizi Pen
- Humira (adalimumab): A biologic used to treat psoriasis, psoriatic arthritis, and other autoimmune conditions. It targets TNF-alpha, a different cytokine.
- Stelara (ustekinumab): A biologic that targets IL-12 and IL-23, used for treating psoriasis and psoriatic arthritis.
- Cosentyx (secukinumab): An IL-17A inhibitor used to treat psoriasis and psoriatic arthritis, similar in effectiveness to Skyrizi.
- Taltz (ixekizumab): Another IL-17A inhibitor used for the same conditions as Skyrizi.
