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Taltz
Taltz, the brand name for ixekizumab, is a biologic medication used to treat various autoimmune conditions including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. It belongs to a class of medications known as interleukin-17A inhibitors (IL-17A inhibitors), which work by targeting and blocking the action of IL-17A, a cytokine involved in inflammatory and immune responses. Taltz helps reduce inflammation, improve skin symptoms, and alleviate joint pain in patients with these autoimmune conditions.
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Frequently Asked Questions
How long does it take for Taltz to work?
Some patients begin to see improvements in their symptoms within 1 to 2 weeks, but full benefits may take 12 weeks or longer.
Can I receive vaccinations while on Taltz?
You should avoid live vaccines while taking Taltz. However, inactivated vaccines (such as the flu shot) are generally considered safe. Always discuss vaccinations with your healthcare provider.
How do I store Taltz?
Store Taltz in the refrigerator and protect it from light. Do not freeze it. Before administering, allow the medication to reach room temperature for 30 minutes, but do not leave it out of the refrigerator for more than 5 days.
Can Taltz cure psoriasis?
Taltz does not cure psoriasis, but it can help manage the symptoms and reduce the severity of flare-ups. Long-term treatment may be necessary to keep the condition under control.
What should I do if I miss a dose of Taltz?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Comprehensive Drug Guide
How Does Taltz Work?
Taltz works by blocking interleukin-17A (IL-17A), a pro-inflammatory cytokine that plays a critical role in the inflammatory process of psoriasis, psoriatic arthritis, and other autoimmune conditions. By inhibiting IL-17A, Taltz helps reduce the abnormal immune response, leading to decreased inflammation, relief from joint pain, and improvement in skin plaques and lesions.
Common Dosages
- Plaque psoriasis: 160 mg (two 80 mg injections) initially, followed by 80 mg every 2 weeks for 12 weeks, then 80 mg every 4 weeks as a maintenance dose.
- Psoriatic arthritis: 160 mg (two 80 mg injections) initially, followed by 80 mg every 4 weeks.
- Ankylosing spondylitis and non-radiographic axial spondyloarthritis: 80 mg every 4 weeks after an initial loading dose of 160 mg.
Typical Dosing
- For plaque psoriasis: Initial dose of 160 mg (two 80 mg injections) at week 0, followed by 80 mg every 2 weeks for 12 weeks, then 80 mg every 4 weeks thereafter.
- For psoriatic arthritis: Initial dose of 160 mg followed by 80 mg every 4 weeks.
- For ankylosing spondylitis and non-radiographic axial spondyloarthritis: Initial dose of 160 mg followed by 80 mg every 4 weeks.
Taltz is administered as a subcutaneous injection, and patients may be trained to self-inject or receive the injection from a healthcare provider.
Typical Dosing
FDA Approved Indications
- Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Active psoriatic arthritis in adults.
- Active ankylosing spondylitis in adults.
- Non-radiographic axial spondyloarthritis in adults with signs of inflammation.
Who Shouldn't Take Taltz?
- Known hypersensitivity to ixekizumab or any components of the formulation.
- Active infections, particularly tuberculosis or other severe infections.
Advice From The Pharmacist
- Taltz is administered as a subcutaneous injection, typically in the abdomen, thigh, or upper arm. Rotate injection sites to avoid irritation or discomfort.
- Store Taltz in the refrigerator and allow it to reach room temperature (about 30 minutes) before administering. Do not shake the autoinjector or syringe.
- Patients should not take Taltz if they have an active infection and should be screened for tuberculosis before starting the medication.
- Do not use Taltz if it is frozen, discolored, or contains particles.
- If a dose is missed, administer it as soon as possible. If the next scheduled dose is near, skip the missed dose and continue with the regular dosing schedule.
Side Effects of Taltz
Common Side Effects
- Injection site reactions (redness, pain, or swelling)
- Upper respiratory infections (common cold, sinus infections)
- Nausea
- Fungal infections, such as tinea (ringworm)
Uncommon/Severe Side Effects
- Serious infections: Including tuberculosis, fungal infections, or bacterial infections. Symptoms may include fever, chills, cough, or difficulty breathing.
- Allergic reactions: Swelling of the face, lips, tongue, or throat, difficulty breathing, or severe rash.
- Crohn’s disease or ulcerative colitis: Worsening or onset of inflammatory bowel disease has been reported in some patients.
Risks and Warnings of Taltz
- Infection risk: Taltz may lower the immune system’s ability to fight infections, increasing the risk of serious infections such as tuberculosis, fungal infections, or bacterial infections. Patients should be screened for tuberculosis before starting Taltz and monitored for signs of infection during treatment.
- Hypersensitivity reactions: Severe allergic reactions, including anaphylaxis, may occur. Discontinue use if signs of an allergic reaction occur.
- Exacerbation of inflammatory bowel disease: Taltz may cause or worsen conditions such as Crohn’s disease or ulcerative colitis. Patients with a history of these conditions should be closely monitored.
Interactions with Taltz
Common Drug Interactions
- Live vaccines: Avoid live vaccines while using Taltz, as the medication may weaken the immune system and increase the risk of infection from live vaccines.
- Immunosuppressants: Combining Taltz with other immunosuppressive drugs (e.g., methotrexate) may increase the risk of infection and reduce the effectiveness of the immune response.
Alternatives to Taltz
- Cosentyx (secukinumab): Another IL-17A inhibitor used to treat similar conditions such as plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis.
- Humira (adalimumab): A TNF-alpha inhibitor used to treat plaque psoriasis, psoriatic arthritis, and other autoimmune conditions.
- Stelara (ustekinumab): A biologic that targets IL-12 and IL-23, used to treat psoriasis and psoriatic arthritis.
- Methotrexate: A traditional disease-modifying antirheumatic drug (DMARD) often used for psoriasis and psoriatic arthritis.
