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Cosentyx
Cosentyx (secukinumab) is a biologic medication used to treat various inflammatory conditions, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. It is a monoclonal antibody that targets interleukin-17A (IL-17A), a protein involved in the inflammatory process, helping to reduce the symptoms of these autoimmune diseases. Cosentyx is often used when traditional therapies are ineffective or not tolerated.
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Frequently Asked Questions
How long does it take for Cosentyx to work?
Most patients begin to see improvements in their symptoms after the first few weeks of treatment, with more significant results by the 12th week.
Can I receive vaccinations while on Cosentyx?
You should avoid live vaccines while taking Cosentyx. However, inactivated vaccines (such as the flu shot) are generally considered safe. Always discuss vaccinations with your healthcare provider.
Can Cosentyx cure psoriasis?
Cosentyx does not cure psoriasis, but it can help manage the symptoms and reduce the severity of flare-ups. Long-term treatment may be necessary to keep the condition under control.
What should I do if I miss a dose of Cosentyx?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses.
Is Cosentyx safe for long-term use?
Cosentyx has been shown to be safe for long-term use in clinical trials, but regular monitoring by your healthcare provider is important to ensure it remains effective and safe for your condition.
Comprehensive Drug Guide
How Does Cosentyx Work?
Cosentyx works by inhibiting IL-17A, a cytokine that plays a central role in inflammation and the overactive immune response seen in conditions like psoriasis and psoriatic arthritis. By blocking IL-17A, Cosentyx reduces inflammation, pain, and the formation of skin plaques, and it also helps to slow down joint damage in patients with psoriatic arthritis and ankylosing spondylitis.
Common Dosages
- Pre-filled syringes or pens: 150 mg each, often requiring two injections for a 300 mg dose.
- Intravenous formulation: For some conditions.
Typical Dosing
- For plaque psoriasis: The usual dose is 300 mg (two 150 mg injections) at weeks 0, 1, 2, 3, and 4, followed by 300 mg every four weeks for maintenance.
- For psoriatic arthritis: The dose may start at 150 mg or 300 mg depending on the severity, with ongoing monthly injections after the initial loading dose.
Typical Dosing
FDA Approved Indications
- Moderate to severe plaque psoriasis
- Psoriatic arthritis
- Ankylosing spondylitis
- Non-radiographic axial spondyloarthritis
- Enthesitis-related arthritis in pediatric patients aged 4 years and older
Who Shouldn't Take Cosentyx?
- Known hypersensitivity to secukinumab or any component of the formulation.
- Active infections, particularly tuberculosis or other severe infections.
Advice From The Pharmacist
- Cosentyx is administered via subcutaneous injection, usually in the abdomen or thigh. Patients can self-administer the injections after proper training or receive them from a healthcare provider.
- Ensure you follow the loading dose schedule for the first five weeks to achieve the best therapeutic results.
- Before starting Cosentyx, you should be screened for tuberculosis (TB) and other infections.
- Store Cosentyx in the refrigerator and allow it to reach room temperature (about 15-30 minutes) before injecting. Do not shake the pen or syringe.
Side Effects of Cosentyx
Common Side Effects
- Upper respiratory infections (common cold)
- Headache
- Diarrhea
- Nasopharyngitis (inflammation of the nose and throat)
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Increased risk of infections, including tuberculosis or fungal infections
- Exacerbation of Crohn’s disease or ulcerative colitis
Risks and Warnings of Cosentyx
- Infection Risk: Cosentyx may lower your immune system's ability to fight infections. Patients with a history of recurrent infections or underlying immune issues should be closely monitored.
- Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, have been reported. Discontinue use if signs of allergic reactions occur, such as rash, swelling, or difficulty breathing.
- Exacerbation of Inflammatory Bowel Disease (IBD): Cosentyx may worsen or trigger IBD in susceptible individuals. Patients with a history of Crohn’s disease or ulcerative colitis should be monitored for worsening symptoms.
Interactions with Cosentyx
Common Drug Interactions
- Immunosuppressants: Combining Cosentyx with other biologics or immunosuppressive medications may increase the risk of infections. This includes drugs like methotrexate or corticosteroids.
- Vaccinations: Live vaccines should be avoided during treatment with Cosentyx, as the medication may reduce the effectiveness of vaccines or increase the risk of infection from live vaccines.
Alternatives to Cosentyx
- Humira (adalimumab): Another biologic targeting TNF-alpha, used for similar conditions like psoriasis and psoriatic arthritis.
- Stelara (ustekinumab): A biologic targeting IL-12 and IL-23, used for psoriasis, psoriatic arthritis, and Crohn’s disease.
- Taltz (ixekizumab): Another IL-17A inhibitor, similar to Cosentyx, used for treating psoriasis and psoriatic arthritis.
- Methotrexate: A traditional disease-modifying antirheumatic drug (DMARD) often used to manage psoriasis and psoriatic arthritis.
