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Skyrizi
Skyrizi, the brand name for risankizumab-rzaa, is a biologic medication used to treat moderate to severe plaque psoriasis in adults and active psoriatic arthritis. It belongs to a class of drugs known as interleukin-23 (IL-23) inhibitors. By targeting the IL-23 cytokine, which plays a key role in the inflammatory process, Skyrizi helps reduce inflammation and improve symptoms such as skin plaques, joint pain, and swelling. It is typically prescribed to individuals who are candidates for systemic therapy or phototherapy.
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Frequently Asked Questions
How long does it take for Skyrizi to start working?
Some patients begin to see improvement in their symptoms within 4 weeks, but full benefits may take 12 weeks or more.
Can I receive vaccinations while on Skyrizi?
You should avoid live vaccines while taking Skyrizi, as your immune system may be weakened. Inactivated vaccines, like the flu shot, are generally considered safe. Always discuss vaccinations with your healthcare provider.
How do I store Skyrizi?
Store Skyrizi in the refrigerator at 2°C to 8°C (36°F to 46°F). Allow it to reach room temperature before injecting, but do not leave it out of the refrigerator for more than 24 hours.
Can Skyrizi cure psoriasis?
Skyrizi does not cure psoriasis, but it can help manage the symptoms and reduce the severity of flare-ups. Long-term treatment may be necessary to maintain control over the condition.
What should I do if I miss a dose of Skyrizi?
If you miss a dose, contact your healthcare provider to schedule the missed dose as soon as possible. After that, resume your regular dosing schedule.
Comprehensive Drug Guide
How Does Skyrizi Work?
Skyrizi works by targeting and inhibiting interleukin-23 (IL-23), a cytokine that plays a major role in the inflammatory and immune response associated with psoriasis and psoriatic arthritis. By blocking IL-23, Skyrizi helps to reduce inflammation, slow down the overproduction of skin cells, and relieve symptoms of joint inflammation. This leads to a reduction in plaque formation on the skin and improvement in joint function for those with psoriatic arthritis.
Common Dosages
- 150 mg/mL pre-filled syringe or pen
Typical Dosing
- For plaque psoriasis: The typical dose is 150 mg administered by subcutaneous injection at weeks 0, 4, and every 12 weeks thereafter.
- For psoriatic arthritis: The typical dose is 150 mg every 12 weeks after an initial dose at weeks 0 and 4.
Skyrizi is administered as a subcutaneous injection and may be self-administered by patients after proper training, or by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Active psoriatic arthritis in adults.
Who Shouldn't Take Skyrizi?
- Known hypersensitivity to risankizumab or any components of the formulation.
- Active infections, particularly tuberculosis (TB) or other serious infections.
Advice From The Pharmacist
- Store Skyrizi in the refrigerator, and allow it to reach room temperature (about 15-30 minutes) before injecting. Do not freeze or shake the medication.
- Skyrizi is injected subcutaneously into the abdomen or thigh, and injection sites should be rotated to avoid irritation.
- Do not use Skyrizi if you have an active infection. Inform your healthcare provider of any signs of infection, such as fever, cough, or flu-like symptoms, before starting or continuing treatment.
- Patients should be screened for tuberculosis (TB) before starting Skyrizi, as it can lower the body’s ability to fight infections.
- Do not administer Skyrizi if it is frozen, discolored, or contains particles.
Side Effects of Skyrizi
Common Side Effects
- Upper respiratory infections (common cold)
- Headache
- Fatigue
- Injection site reactions (redness, itching, or swelling)
Uncommon/Severe Side Effects
- Serious infections: Including tuberculosis, bacterial, fungal, or viral infections. Symptoms may include fever, chills, persistent cough, or difficulty breathing.
- Allergic reactions: Rash, itching, swelling of the face or throat, or difficulty breathing.
Risks and Warnings of Skyrizi
- Infection risk: Skyrizi may lower your immune system's ability to fight infections. Patients with a history of recurrent infections or those with underlying immune conditions should be closely monitored for signs of infection.
- Tuberculosis risk: Patients should be screened for tuberculosis before starting Skyrizi. If latent TB is present, it should be treated before initiating therapy. If active TB is diagnosed during therapy, Skyrizi should be discontinued until the infection is treated.
- Hypersensitivity reactions: Severe allergic reactions, including anaphylaxis, have been reported. Discontinue use if signs of allergic reactions occur, such as swelling, rash, or difficulty breathing.
Interactions with Skyrizi
Common Drug Interactions
- Live vaccines: Avoid using live vaccines during Skyrizi treatment, as the medication can weaken the immune system and increase the risk of infection from live vaccines.
- Other immunosuppressive agents: Combining Skyrizi with other biologics or immunosuppressants may increase the risk of infections.
Alternatives to Skyrizi
- Cosentyx (secukinumab): An IL-17A inhibitor used to treat plaque psoriasis and psoriatic arthritis.
- Taltz (ixekizumab): Another IL-17A inhibitor used to treat plaque psoriasis and psoriatic arthritis.
- Humira (adalimumab): A TNF-alpha inhibitor used for psoriasis, psoriatic arthritis, and other autoimmune conditions.
- Stelara (ustekinumab): A biologic that targets IL-12 and IL-23, used to treat plaque psoriasis and psoriatic arthritis.
