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Sernivo
Sernivo is the brand name for betamethasone dipropionate, a topical corticosteroid used to treat the symptoms of mild to moderate plaque psoriasis in adults. As a corticosteroid, Sernivo helps reduce inflammation, redness, and itching associated with psoriasis by suppressing the body’s immune response in the skin. It is formulated as a spray, which is applied directly to the affected areas.
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Frequently Asked Questions
How long does it take for Sernivo to start working?
Sernivo may start to reduce inflammation and improve psoriasis symptoms within a few days of use, but full benefits may take up to 4 weeks.
Can I use Sernivo on my face?
No, Sernivo should generally not be used on sensitive areas like the face, groin, or underarms unless directed by a healthcare provider, as these areas are more prone to side effects like skin thinning.
What should I do if I miss a dose of Sernivo?
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can Sernivo be used long-term?
No, Sernivo is typically prescribed for short-term use (up to 4 weeks). Long-term use can lead to side effects such as skin thinning, stretch marks, and systemic absorption of the corticosteroid.
What should I do if my symptoms don’t improve after 4 weeks?
If your symptoms do not improve or if they worsen after 4 weeks of using Sernivo, contact your healthcare provider for further evaluation or alternative treatment options.
What should I do if my symptoms don’t improve after 4 weeks?
If your symptoms do not improve or if they worsen after 4 weeks of using Sernivo, contact your healthcare provider for further evaluation or alternative treatment options.
Comprehensive Drug Guide
How Does Sernivo Work?
Sernivo contains betamethasone dipropionate, a corticosteroid that works by reducing inflammation, itching, and redness. It suppresses the activity of certain cells in the immune system that cause inflammation, which is overactive in skin conditions like psoriasis. By inhibiting inflammatory mediators, Sernivo helps to alleviate the symptoms of psoriasis, such as thickened, scaly skin plaques.
Common Dosages
- Sernivo is available as a 0.05% topical spray. It is typically applied twice daily to the affected areas.
Typical Dosing
- For plaque psoriasis: Apply a thin layer of Sernivo twice daily to the affected skin areas. The spray should be used for up to 4 weeks or as directed by your healthcare provider. Do not use more than 50 grams per week.
Typical Dosing
FDA Approved Indications
- Treatment of mild to moderate plaque psoriasis in adults.
Who Shouldn't Take Sernivo?
- Known hypersensitivity to betamethasone dipropionate or any other components of the formulation.
- Untreated bacterial, fungal, or viral skin infections, as corticosteroids can worsen these infections.
Advice From The Pharmacist
- Shake the bottle well before using the spray.
- Apply Sernivo only to the affected areas. Avoid contact with the eyes, mouth, or mucous membranes. If contact occurs, rinse thoroughly with water.
- Do not use Sernivo for more than 4 weeks without consulting your healthcare provider, as long-term use can lead to thinning of the skin or other complications.
- Do not cover the treated area with occlusive dressings (such as bandages or wraps) unless directed by a healthcare provider, as this can increase the absorption of the medication and the risk of side effects.
- Wash your hands after applying Sernivo unless your hands are the affected area being treated.
- Contact your healthcare provider if you do not see improvement after 4 weeks or if your condition worsens.
Side Effects of Sernivo
Common Side Effects
- Mild burning, stinging, or irritation at the application site
- Dryness or peeling of the skin
- Itching
Uncommon/Severe Side Effects
- Thinning of the skin (atrophy)
- Stretch marks (striae)
- Allergic contact dermatitis: Rash, itching, or swelling at the application site.
- HPA axis suppression: Long-term use of high-potency corticosteroids can lead to systemic absorption, resulting in hormonal imbalances.
Risks and Warnings of Sernivo
- Skin thinning and atrophy: Prolonged use of Sernivo can cause thinning of the skin, making it more prone to bruising or tearing. Use the spray only as directed and avoid long-term use.
- Systemic absorption: Corticosteroids, when used over large areas of the body or for prolonged periods, can be absorbed into the bloodstream and cause hormonal imbalances (HPA axis suppression). This is more likely to occur when large amounts are used or when occlusive dressings are applied.
- Infection risk: Corticosteroids can mask or worsen infections. If you suspect an infection at the treatment site, discontinue use and contact your healthcare provider.
Interactions with Sernivo
Common Drug Interactions
- Other topical corticosteroids: Using multiple corticosteroids on the same area can increase the risk of side effects, such as skin thinning or systemic absorption.
- Immunosuppressive medications: Using Sernivo along with other medications that suppress the immune system (e.g., oral corticosteroids or biologics) can increase the risk of infections or side effects.
Alternatives to Sernivo
- Clobetasol propionate: A high-potency topical corticosteroid used to treat psoriasis and other inflammatory skin conditions.
- Fluocinonide: A topical corticosteroid that helps reduce inflammation in conditions like psoriasis.
- Calcipotriene (Dovonex): A vitamin D analog often used to treat plaque psoriasis, sometimes in combination with corticosteroids.
- Tacrolimus ointment (Protopic): An immunomodulator used to treat inflammatory skin conditions like eczema and psoriasis without the side effects associated with steroids.
