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Roszet
Roszet is a prescription combination medication that contains rosuvastatin calcium and ezetimibe. It is used to help lower low-density lipoprotein (LDL) cholesterol and total cholesterol levels in individuals with high cholesterol, including those with primary hyperlipidemia and mixed dyslipidemia. Rosuvastatin is a statin that reduces the production of cholesterol in the liver, while ezetimibe is a cholesterol absorption inhibitor that reduces the amount of cholesterol absorbed from the diet. Together, these medications work to lower cholesterol levels and reduce the risk of cardiovascular events, such as heart attacks and strokes.
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Frequently Asked Questions
How long does it take for Roszet to lower cholesterol?
Roszet may start lowering cholesterol within 2 to 4 weeks, but it may take up to 12 weeks to see the full effects. Your doctor will monitor your cholesterol levels during treatment.
Can I drink alcohol while taking Roszet?
It is recommended to limit alcohol consumption while taking Roszet, as alcohol can increase the risk of liver damage, which is a potential side effect of rosuvastatin.
What should I do if I miss a dose of Roszet?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and take your next dose as usual. Do not take two doses at once.
Can I take Roszet with other cholesterol-lowering medications?
In some cases, Roszet may be used in combination with other cholesterol-lowering medications, but it is important to inform your healthcare provider about all medications you are taking to avoid potential interactions.
Is Roszet safe during pregnancy?
No, Roszet should not be taken during pregnancy, as statins can harm the developing fetus. Women of childbearing age should use effective contraception while taking Roszet, and it should be discontinued immediately if pregnancy occurs.
Comprehensive Drug Guide
How Does Roszet Work?
- Rosuvastatin inhibits HMG-CoA reductase, an enzyme involved in cholesterol production in the liver. This leads to a reduction in LDL cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol levels.
- Ezetimibe blocks the absorption of cholesterol in the intestines, reducing the amount of cholesterol absorbed from dietary sources. This further decreases LDL cholesterol levels in the bloodstream.
Together, these mechanisms provide a more comprehensive approach to lowering cholesterol and managing hyperlipidemia.
Common Dosages
- 5 mg rosuvastatin / 10 mg ezetimibe
- 10 mg rosuvastatin / 10 mg ezetimibe
- 20 mg rosuvastatin / 10 mg ezetimibe
- 40 mg rosuvastatin / 10 mg ezetimibe
Typical Dosing
- The recommended starting dose of Roszet is 5 mg / 10 mg or 10 mg / 10 mg taken once daily.
- The dose can be increased based on the patient’s cholesterol levels and response to treatment, with a maximum dose of 40 mg / 10 mg daily.
- Roszet can be taken with or without food, and the tablet should be swallowed whole with water.
Typical Dosing
FDA Approved Indications
- Primary hyperlipidemia: To reduce elevated cholesterol levels, including LDL cholesterol, total cholesterol, and triglycerides, while increasing HDL cholesterol.
- Mixed dyslipidemia: A combination of elevated cholesterol and triglyceride levels, where Roszet helps lower LDL cholesterol and triglycerides and raise HDL cholesterol.
- Prevention of cardiovascular events: To reduce the risk of heart attack, stroke, and other cardiovascular complications in patients with high cholesterol.
Who Shouldn't Take Roszet?
- Active liver disease, including persistent elevated liver enzymes.
- Known hypersensitivity to rosuvastatin, ezetimibe, or any component of the medication.
- Pregnancy or breastfeeding, as statins can harm the fetus and should not be used during pregnancy.
Advice From The Pharmacist
- Take Roszet once daily at the same time each day, with or without food.
- Avoid drinking large amounts of grapefruit juice while taking Roszet, as it can increase the risk of side effects by raising rosuvastatin levels in the bloodstream.
- Roszet may take several weeks to fully lower your cholesterol levels. Your doctor may monitor your cholesterol levels and liver function periodically during treatment.
- Alcohol use should be limited, as combining alcohol with rosuvastatin can increase the risk of liver damage.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor, as these may be signs of a rare but serious side effect called rhabdomyolysis.
Side Effects of Roszet
Common Side Effects
- Muscle pain or weakness
- Headache
- Diarrhea
- Fatigue
- Upper respiratory infections
Uncommon/Severe Side Effects
- Rhabdomyolysis: A severe condition involving muscle breakdown, which can lead to kidney damage. Symptoms include muscle pain, weakness, and dark-colored urine.
- Liver problems, including liver enzyme elevations. Symptoms may include yellowing of the skin or eyes (jaundice) and dark urine.
- Hypersensitivity reactions, including rash, itching, or swelling of the face, lips, or tongue.
Risks and Warnings of Roszet
- Muscle-related risks: Roszet, like other statins, may increase the risk of muscle pain, tenderness, or weakness, especially in higher doses. Rarely, this can lead to rhabdomyolysis, a serious condition that requires immediate medical attention.
- Liver toxicity: Roszet may cause elevated liver enzymes and liver damage. Liver function should be monitored before starting treatment and periodically thereafter.
- Diabetes Risk: Statins, including rosuvastatin, may slightly increase the risk of developing type 2 diabetes, especially in individuals with risk factors for diabetes.
Interactions with Roszet
Common Drug Interactions
- Grapefruit juice: Consuming grapefruit juice while taking Roszet can increase the risk of side effects due to higher rosuvastatin levels in the bloodstream.
- Warfarin: Combining Roszet with warfarin or other blood thinners may increase the risk of bleeding. Monitoring of INR levels may be needed.
- Cyclosporine: This medication can increase rosuvastatin levels, increasing the risk of muscle-related side effects.
- Fibrates (e.g., gemfibrozil): These medications can increase the risk of muscle toxicity when used with Roszet.
Alternatives to Roszet
- Crestor (rosuvastatin): A statin used to lower cholesterol, similar to the rosuvastatin component of Roszet.
- Zetia (ezetimibe): A cholesterol absorption inhibitor that is part of the combination in Roszet, available as a standalone medication.
- Lipitor (atorvastatin): Another statin used to lower cholesterol and reduce the risk of cardiovascular events.
- Vytorin (ezetimibe/simvastatin): A combination of ezetimibe and simvastatin used to lower cholesterol.
