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Quinapril-hydroCHLOROthiazide
Quinapril-hydroCHLOROthiazide is a combination medication used to treat high blood pressure (hypertension). Quinapril is an angiotensin-converting enzyme (ACE) inhibitor, which helps relax blood vessels by preventing the formation of a hormone that causes blood vessels to tighten. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps the body eliminate excess salt and water, reducing fluid buildup and lowering blood pressure. This combination is effective in managing blood pressure and reducing the risk of stroke and heart attack.
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Frequently Asked Questions
How long does it take for Quinapril-hydroCHLOROthiazide to lower blood pressure?
It may take 1 to 2 weeks to see the full blood pressure-lowering effects of Quinapril-hydroCHLOROthiazide.
Can I take potassium supplements with Quinapril-hydroCHLOROthiazide?
No, avoid taking potassium supplements or salt substitutes unless advised
Can Quinapril-hydroCHLOROthiazide cause a persistent cough?
Yes, cough is a known side effect of ACE inhibitors like quinapril. If the cough becomes bothersome, talk to your healthcare provider about possible alternatives.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I drink alcohol while taking Quinapril-hydroCHLOROthiazide?
Alcohol may increase the blood pressure-lowering effects of this medication, leading to dizziness or fainting. It’s best to limit alcohol consumption while taking this medication. Alcohol may increase the blood pressure-lowering effects of this medication, leading to dizziness or fainting. It’s best to limit alcohol consumption while taking this medication.
Can I drink alcohol while taking Quinapril-hydroCHLOROthiazide?
Alcohol may increase the blood pressure-lowering effects of this medication, leading to dizziness or fainting. It’s best to limit alcohol consumption while taking this medication. Alcohol may increase the blood pressure-lowering effects of this medication, leading to dizziness or fainting. It’s best to limit alcohol consumption while taking this medication.
Comprehensive Drug Guide
How Does Quinapril-hydroCHLOROthiazide Work?
- Quinapril inhibits the angiotensin-converting enzyme, which reduces the production of angiotensin II, a substance that narrows blood vessels and raises blood pressure.
- Hydrochlorothiazide helps the kidneys eliminate excess sodium and water from the body, reducing blood volume and lowering blood pressure.
Common Dosages
- 10 mg Quinapril / 12.5 mg Hydrochlorothiazide
- 20 mg Quinapril / 12.5 mg Hydrochlorothiazide
- 20 mg Quinapril / 25 mg Hydrochlorothiazide
Typical Dosing
- The usual starting dose for hypertension is one tablet once daily, typically with a dosage of 10/12.5 mg or 20/12.5 mg, depending on the patient’s response and medical history.
Typical Dosing
FDA Approved Indications
- Hypertension (high blood pressure)
Who Shouldn't Take Quinapril-hydroCHLOROthiazide?
- Anuria (inability to urinate)
- Angioedema related to previous ACE inhibitor use
- Hypersensitivity to quinapril, hydrochlorothiazide, or any of the components
Advice From The Pharmacist
- Take Quinapril-hydroCHLOROthiazide as prescribed, usually once daily, and it can be taken with or without food.
- Avoid potassium supplements or potassium-containing salt substitutes, as ACE inhibitors can increase potassium levels in the blood.
- Monitor your blood pressure regularly and inform your healthcare provider if you experience symptoms like dizziness, swelling, or shortness of breath.
- Be cautious of dehydration, as this medication increases urine output and may cause dizziness or low blood pressure if you're not adequately hydrated.
Side Effects of Quinapril-hydroCHLOROthiazide
Common Side Effects
- Dizziness
- Cough (from quinapril)
- Headache
- Increased urination (from hydrochlorothiazide)
Uncommon/Severe Side Effects
- Angioedema (swelling of the face, lips, throat, or tongue)
- Hyperkalemia (elevated potassium levels)
- Severe hypotension (low blood pressure)
Risks and Warnings of Quinapril-hydroCHLOROthiazide
- Angioedema Risk: Quinapril can cause angioedema, a potentially serious allergic reaction characterized by swelling of the face, lips, or throat. Seek immediate medical attention if this occurs.
- Hyperkalemia: Quinapril can increase potassium levels in the blood. Avoid taking potassium supplements or salt substitutes unless directed by your healthcare provider.
- Dehydration and Electrolyte Imbalance: Hydrochlorothiazide can cause increased urination, leading to dehydration and low sodium levels. Make sure to stay hydrated and monitor for symptoms of electrolyte imbalance, such as confusion or muscle cramps.
Interactions with Quinapril-hydroCHLOROthiazide
Common Drug Interactions
- Potassium supplements or potassium-sparing diuretics: Can increase the risk of hyperkalemia.
- NSAIDs (e.g., ibuprofen, naproxen): May reduce the effectiveness of ACE inhibitors and increase the risk of kidney problems.
- Lithium: ACE inhibitors can increase lithium levels, leading to toxicity.
Alternatives to Quinapril-hydroCHLOROthiazide
- Lisinopril-Hydrochlorothiazide: Another ACE inhibitor and thiazide diuretic combination used for high blood pressure.
- Losartan-Hydrochlorothiazide: A combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic for hypertension.
- Amlodipine-Benazepril: A combination of a calcium channel blocker and an ACE inhibitor for blood pressure management.
