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Pylera
Pylera is a combination medication used for the treatment of Helicobacter pylori (H. pylori) infection, which is a common cause of peptic ulcers. It consists of three active ingredients: bismuth subsalicylate, metronidazole, and tetracycline hydrochloride. This combination works together to eradicate the H. pylori bacteria and promote healing of the stomach lining.
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Frequently Asked Questions
How quickly does Pylera start to work?
Patients may begin to notice symptom relief within a few days of starting treatment, but it is essential to complete the full course to ensure eradication of the bacteria.
Can I stop taking Pylera if I feel better?
Can I stop taking Pylera if I feel better?
Are there any specific dietary restrictions while taking Pylera?
There are no specific dietary restrictions; however, avoiding alcohol is advisable during treatment, especially with metronidazole.
What should I do if I miss a dose of Pylera?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Pylera safe for long-term use?
Pylera is intended for short-term use to treat H. pylori infections. Long-term use of antibiotics should be discussed with a healthcare provider to assess risks and benefits. Regular follow-ups are important to monitor for any potential side effects.
Is Pylera safe for long-term use?
Pylera is intended for short-term use to treat H. pylori infections. Long-term use of antibiotics should be discussed with a healthcare provider to assess risks and benefits. Regular follow-ups are important to monitor for any potential side effects.
Comprehensive Drug Guide
How Does Pylera Work?
- Bismuth subsalicylate works by coating the stomach lining and protecting it from acid, while also having mild antibacterial properties.
- Metronidazole is an antibiotic that works by inhibiting the growth of bacteria and protozoa.
- Tetracycline is another antibiotic that inhibits bacterial protein synthesis, leading to the death of the H. pylori bacteria.
Common Dosages
- Capsules: Each capsule contains 140 mg of bismuth subsalicylate, 125 mg of metronidazole, and 125 mg of tetracycline hydrochloride.
Typical Dosing
- The usual dosage for adults is three capsules taken four times daily, with meals and at bedtime, for 10 days. It is important to follow the dosing schedule carefully to ensure effective treatment.
Typical Dosing
FDA Approved Indications
- Eradication of H. pylori infection in patients with peptic ulcer disease.
Who Shouldn't Take Pylera?
- Known hypersensitivity to any components of the formulation.
- History of aspirin sensitivity or gastrointestinal bleeding.
- Severe liver disease or renal impairment.
Advice From The Pharmacist
- Advise patients to take Pylera exactly as prescribed, and to complete the full course of therapy even if symptoms improve.
- Instruct patients to take the capsules with a full glass of water and to avoid taking them within two hours of taking antacids or other medications containing bismuth.
- Inform patients about potential side effects, especially gastrointestinal symptoms, and encourage them to report any severe reactions or persistent side effects.
Side Effects of Pylera
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Darkening of the tongue or stools
Uncommon/Severe Side Effects
- Allergic reactions (such as rash, itching, or difficulty breathing)
- Superinfection due to antibiotic use
Risks and Warnings of Pylera
- Antibiotic Resistance: Overuse or misuse of antibiotics may lead to antibiotic resistance; patients should be counseled on appropriate use.
- Gastrointestinal Effects: Monitor for signs of gastrointestinal side effects, and inform patients about the possibility of discoloration of stools or tongue due to bismuth subsalicylate.
Interactions with Pylera
Common Drug Interactions
- Antacids: Avoid taking antacids within two hours of Pylera, as they may interfere with the absorption of the medication.
- Other Antibiotics: Careful monitoring is necessary when used with other antibiotics to prevent potential interactions and additive side effects.
Alternatives to Pylera
- Other H. pylori Treatment Regimens: Such as triple therapy with omeprazole, amoxicillin, and clarithromycin may be considered based on local guidelines and patient-specific factors.
- Bismuth-containing Regimens: Other formulations containing bismuth may also be effective for treating H. pylori infections.
