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Pravastatin Sodium

Pravastatin belongs to a group of drugs called statins, also known as HMG-CoA reductase inhibitors. It's used to lower bad cholesterol and raise good cholesterol in the blood. Retaining a balanced cholesterol level is essential in preventing heart diseases and strokes. Some common side effects include headache, muscle pain, and nausea, although these are typically mild.

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Frequently Asked Questions

Can I take pravastatin if I am pregnant or breastfeeding?
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Pravastatin belongs to pregnancy category X which implies it may harm the fetus. Likewise, it's advised to avoid this medication while breastfeeding. Always consult with your healthcare provider for safer alternatives.

Does pravastatin interact with grapefruit?
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Unlike some other statins, pravastatin is not substantially affected by grapefruit. Thus, you can eat grapefruit or drink grapefruit juice while taking pravastatin.

I missed a dose of pravastatin, what should I do?
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If it's close to the time for your next dose, skip the missed dose and go back to your normal time. Don t take two doses at the same time or extra doses.

Will pravastatin affect my liver?
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Although very rare, pravastatin can cause liver problems. Regular liver function tests might be performed. Inform your doctor right away if you have symptoms of liver problems like dark urine, feeling tired, lack of appetite, upset stomach or abdominal pain, light-colored stools, or yellow skin or eyes.

Can I drink alcohol while taking pravastatin?
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While occasional alcohol intake is generally safe, excessive consumption can increase the risk of liver damage and can also further raise triglyceride (fat) levels in your blood. Always consult with your healthcare provider for personalized advice.

Comprehensive Drug Guide

How Does Pravastatin Sodium Work?

Pravastatin is a synthetic lipid-lowering agent that inhibits HMG-CoA reductase, an enzyme that catalyzes an early and rate-limiting step in the biosynthesis of cholesterol.

What is Pravastatin Sodium Used For?

FDA indications: Pravastatin is used to reduce cholesterol and triglycerides in the blood, including the treatment of high cholesterol, prevention of cardiovascular disease, and prevention of heart attacks and strokes.

Common Dosages

Tablets: 10mg, 20mg, 40mg

Typical Dosing

FDA Approved Indications

  • For FDA-approved indications: High Cholesterol: 10-20mg per day initially, can increase to 40mg per day as needed
  • Prevention of Cardiovascular Disease: 40mg per day

Who Shouldn't Take Pravastatin Sodium?

  • Have liver disease.
  • Are pregnant, planning to become pregnant, or breastfeeding.
  • Have a history of severe allergic reactions to statins.
  • Have muscle disease.

Advice From The Pharmacist

  • Take pravastatin consistently, either in the evening or before bedtime.
  • Do not take pravastatin with food that is high in fats.
  • Regular blood tests may be needed to check how well the drug is working.
  • Avoid excessive consumption of alcohol.
  • Report any unexplained muscle pain, tenderness, or weakness to your doctor.
  • Do not stop taking pravastatin unless directed by your physician as your cholesterol levels may spike.

Side Effects of Pravastatin Sodium

Common Side Effects

  • Common side effects:
  • You might have a headache, nausea, or rash.
  • Your muscles might be sore.

Uncommon/Severe Side Effects

  • Rare side effects:
  • Pravastatin may cause memory loss or confusion.
  • Severe side effects:
  • Rarely, pravastatin can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure.
  • Contact your doctor immediately if you have unexplained muscle pain, tenderness, or weakness.

Risks and Warnings of Pravastatin Sodium

  • Users with a history of liver disease, kidney disease, or alcoholism should exercise caution when using pravastatin.
  • Regular liver function tests are recommended to detect any potential damage early.

Interactions with Pravastatin Sodium

Common Drug Interactions

  • Gemfibrozil
  • Niacin
  • Colchicine
  • Certain immunosuppressants (like cyclosporine)
  • Other drugs affecting liver enzymes

Alternatives to Pravastatin Sodium

  • Atorvastatin
  • Simvastatin
  • Rosuvastatin
  • Lovastatin
  • Fluvastatin