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Pennsaid
Pennsaid (diclofenac sodium) is a topical nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis pain in the knees and other joints. It is applied directly to the skin over the affected area, providing localized relief while minimizing systemic side effects associated with oral NSAIDs.
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Frequently Asked Questions
How quickly does Pennsaid work?
Patients may start to notice pain relief within a few days of consistent use, but optimal effects may take longer.
Can I use Pennsaid with other topical medications?
Consult your healthcare provider before using other topical medications on the same area to avoid interactions.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next application, skip the missed dose and continue with your regular schedule. Do not double up.
Is Pennsaid safe during pregnancy?
Consult your healthcare provider before using Pennsaid during pregnancy to evaluate potential risks and benefits.
What are the signs of serious side effects to watch for?
Monitor for symptoms of severe allergic reactions or unusual skin reactions, and seek immediate medical attention if these occur.
Comprehensive Drug Guide
How Does Pennsaid Work?
Pennsaid works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which play a key role in the production of prostaglandins—substances that mediate inflammation and pain. By reducing the levels of these inflammatory mediators, Pennsaid helps alleviate pain and inflammation in the affected joints.
Common Dosages
Pennsaid is typically available in the following form:
- Topical solution: 1.5% diclofenac sodium in a pump spray bottle.
Typical Dosing
- Adults: The recommended dosage is to apply 2 pumps (approximately 2 g) of Pennsaid to the affected knee or joint twice daily. The area should be massaged gently until the solution is absorbed.
Typical Dosing
FDA Approved Indications
- The treatment of pain associated with osteoarthritis in the knees and other joints.
Who Shouldn't Take Pennsaid?
- Known hypersensitivity to diclofenac or any component of the formulation
- History of asthma, urticaria, or other allergic reactions after taking NSAIDs
Advice From The Pharmacist
- Apply Pennsaid to clean, dry skin, and avoid covering the area with bandages or heating pads after application unless directed by a healthcare provider.
- Wash hands after applying the medication to avoid contact with the eyes and mucous membranes.
- Inform your healthcare provider about any other medications you are taking to avoid potential interactions.
Side Effects of Pennsaid
Common Side Effects
- Application site reactions (redness, itching, or rash)
- Dry skin
- Gastrointestinal discomfort (if absorbed systemically)
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Liver function abnormalities
Risks and Warnings of Pennsaid
- Skin Reactions: Monitor for local skin reactions and discontinue use if severe irritation occurs.
- Cardiovascular Risks: Use caution in patients with cardiovascular disease or risk factors, as NSAIDs can increase the risk of serious cardiovascular events.
Interactions with Pennsaid
Common Drug Interactions
- Other NSAIDs: Avoid concurrent use with other NSAIDs to minimize the risk of side effects.
- Anticoagulants: Use with caution, as NSAIDs can increase the risk of bleeding.
Alternatives to Pennsaid
- Oral NSAIDs: Such as ibuprofen or naproxen for pain management.
- Other Topical Analgesics: Such as capsaicin cream or other topical NSAIDs.
