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Oravig
Oravig, the brand name for miconazole, is an antifungal medication used to treat oropharyngeal candidiasis (commonly known as oral thrush), a fungal infection of the mouth and throat caused by Candida species. It is typically used in patients who are immunocompromised or undergoing treatments like chemotherapy or radiation therapy, which can make them more susceptible to fungal infections. Oravig is designed as a buccal tablet that adheres to the gum, releasing medication directly to the site of infection.
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Frequently Asked Questions
How long does it take for Oravig to start working?
Most patients begin to notice improvement in their symptoms within a few days of starting Oravig. However, it is important to complete the full 14-day course of treatment to ensure the infection is fully eradicated.
Can I eat and drink while using Oravig?
Yes, you can eat and drink while using Oravig, but avoid foods that may disturb the tablet, such as chewing gum or very hot liquids that could loosen the tablet.
What should I do if the Oravig tablet falls off?
If the tablet falls off within 6 hours of application, you can replace it with a new tablet. If it falls off after 6 hours, wait until the next dose is scheduled.
Can I use Oravig if I wear dentures?
Oravig is generally safe for patients with dentures, but it is important to ensure the tablet is properly adhered to the gum. Denture wearers should consult their healthcare provider for specific instructions.
What should I do if my symptoms do not improve?
If your symptoms do not improve or worsen after a few days of using Oravig, contact your healthcare provider. You may need a different treatment or additional medications.
Comprehensive Drug Guide
How Does Oravig Work?
Oravig works by inhibiting the production of ergosterol, a key component of fungal cell membranes. By disrupting the fungal cell membrane, Oravig prevents the growth and replication of Candida species, effectively treating the infection. The buccal tablet adheres to the gum and releases the medication gradually over time, ensuring continuous exposure to the affected area.
Common Dosages
- 50 mg buccal tablets
Typical Dosing
- For the treatment of oropharyngeal candidiasis: Place one 50 mg buccal tablet in the upper gum region, above the incisor tooth, once daily. The tablet adheres to the gum and slowly dissolves over the course of the day.
- The recommended treatment duration is 14 days, or as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Treatment of oropharyngeal candidiasis (oral thrush) in adults.
Who Shouldn't Take Oravig?
- Known hypersensitivity or allergy to miconazole or any of its components.
- Liver dysfunction or hepatotoxicity, as miconazole is metabolized by the liver.
Advice From The Pharmacist
- Apply the Oravig tablet to your upper gum once daily, preferably in the morning. Place the rounded side of the tablet against the gum, and it should naturally adhere.
- Do not chew or swallow the tablet. It is designed to dissolve slowly over several hours.
- If the tablet falls off within the first 6 hours, you can replace it with a new one. If more than 6 hours have passed, wait until the next scheduled dose.
- Avoid touching or pressing the tablet once it is in place, as this could dislodge it.
- Continue using Oravig for the full treatment course, even if your symptoms improve before the 14-day duration is complete.
Side Effects of Oravig
Common Side Effects
- Headache
- Nausea
- Gum discomfort or irritation
- Dry mouth
- Taste disturbances
Uncommon/Severe Side Effects
- Allergic reactions: Symptoms include rash, itching, swelling, or difficulty breathing.
- Hepatotoxicity: Signs of liver issues may include jaundice (yellowing of the skin or eyes), dark urine, or severe fatigue.
Risks and Warnings of Oravig
- Allergic reactions: Miconazole may cause severe allergic reactions in rare cases. If you experience swelling of the face, lips, or throat, or difficulty breathing, seek emergency medical attention.
- Liver function: Oravig is metabolized by the liver, and patients with pre-existing liver conditions or a history of liver disease should be closely monitored.
- Not for use in children: Oravig is not typically recommended for use in pediatric patients unless specifically prescribed by a healthcare provider.
Interactions with Oravig
Common Drug Interactions
- Warfarin: Miconazole can increase the effects of warfarin, a blood thinner, raising the risk of bleeding. Patients on warfarin should have their INR levels closely monitored.
- Oral hypoglycemic agents: Miconazole may increase the effects of medications used to lower blood sugar, potentially causing hypoglycemia.
- Phenytoin: Miconazole can increase the levels of phenytoin, a seizure medication, leading to toxicity.
Alternatives to Oravig
- Nystatin oral suspension: An antifungal medication often used as a swish-and-swallow treatment for oral thrush.
- Fluconazole (Diflucan): An oral antifungal used to treat a variety of fungal infections, including oral thrush.
- Clotrimazole lozenges (Mycelex): Another topical antifungal treatment for oral thrush that is slowly dissolved in the mouth.
