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Nystatin

Nystatin is an antifungal medication used primarily to treat fungal infections caused by Candida species, particularly in the skin, mouth (oral thrush), and gastrointestinal tract. It works by disrupting the fungal cell membrane, leading to cell death.

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Frequently Asked Questions

How quickly does Nystatin work?
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Many patients may notice improvements in symptoms within a few days of starting treatment.

Can I use Nystatin with other skin products?
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It is best to avoid using other topical products on the same area unless directed by your healthcare provider.

What should I do if I miss a dose?
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If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next application, skip the missed dose and continue with your regular schedule.

Are there any dietary restrictions while using Nystatin?
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There are no specific dietary restrictions while using Nystatin.

Is Nystatin safe during pregnancy or breastfeeding?
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Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Nystatin during these periods.

Comprehensive Drug Guide

How Does Nystatin Work?

Nystatin binds to ergosterol, a key component of fungal cell membranes. This binding increases the permeability of the cell membrane, causing leakage of intracellular components and ultimately resulting in cell death.

Common Dosages

  • Topical Cream/Ointment: commonly in 100,000 units/g.
  • Oral Suspension: typically 100,000 units/mL.
  • Tablets: 500,000 units.

Typical Dosing

  • For Cutaneous Candidiasis: Apply a thin layer of nystatin cream or ointment to the affected area two to three times daily.
  • For Oral Thrush: Swish the oral suspension in the mouth for a few minutes before swallowing, typically four times daily.


Typical Dosing

FDA Approved Indications

  • Cutaneous Candidiasis: for treating skin infections caused by Candida.
  • Oral Thrush: for the treatment of oropharyngeal candidiasis.
  • Intestinal Candidiasis: sometimes used for gastrointestinal infections.

Who Shouldn't Take Nystatin?

  • Known hypersensitivity to nystatin or any component of the formulation.
  • Open wounds or severely irritated skin in the area of application.


Advice From The Pharmacist

  • Apply Nystatin only to the affected areas and avoid contact with eyes and mucous membranes.
  • For oral suspension, ensure to use the medication as directed and maintain oral hygiene to help manage oral thrush.
  • Monitor for any signs of irritation or allergic reactions.


Side Effects of Nystatin

Common Side Effects

  • Skin irritation
  • Burning or itching at the application site
  • Nausea (with oral use)


Uncommon/Severe Side Effects

  • Severe allergic reactions (rash, itching, swelling).

Risks and Warnings of Nystatin

  • Irritation: Monitor for signs of irritation; discontinue use if severe reactions occur.
  • Effectiveness: If symptoms do not improve within a week of starting treatment, consult a healthcare provider.

Interactions with Nystatin

Common Drug Interactions

  • Other Topical Products: Use caution when applying other topical treatments on the same area to avoid increased irritation.

Alternatives to Nystatin

  • Other Antifungal Medications: Such as fluconazole or clotrimazole for similar indications.
  • Non-pharmacological Treatments: Maintaining good hygiene practices to prevent fungal infections.