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Naproxen Sodium ER
Naproxen Sodium ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions such as arthritis, musculoskeletal pain, and gout. The extended-release formulation allows for prolonged therapeutic effects, reducing the frequency of dosing.
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Frequently Asked Questions
How quickly does Naproxen Sodium ER work?
Patients may begin to notice relief from pain and inflammation within 30 minutes to 1 hour after taking the medication.
Can I take Naproxen Sodium ER with food?
Yes, it is recommended to take it with food to help reduce gastrointestinal irritation.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Naproxen Sodium ER?
There are no specific dietary restrictions while using Naproxen Sodium ER, but limiting alcohol intake is advisable due to potential gastrointestinal risks.
Is Naproxen Sodium ER safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Naproxen Sodium ER during these periods.
Comprehensive Drug Guide
How Does Naproxen Sodium ER Work?
Naproxen works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the synthesis of prostaglandins. By reducing the production of these inflammatory chemicals, naproxen alleviates pain and inflammation.
Common Dosages
- Extended-Release Tablets: Common strengths include 375 mg and 500 mg.
Typical Dosing
- The usual starting dose for adults is 750 mg as an initial dose, followed by 375 mg to 500 mg once daily. Dosing may be adjusted based on the severity of the condition and individual response, with a maximum daily dose typically not exceeding 1500 mg.
Typical Dosing
FDA Approved Indications
- Osteoarthritis
- Rheumatoid Arthritis
- Ankylosing Spondylitis
- Acute Gout Flare
- Pain Management: for various types of pain including menstrual cramps and musculoskeletal pain.
Who Shouldn't Take Naproxen Sodium ER?
- Known hypersensitivity to naproxen, other NSAIDs, or any component of the formulation.
- History of asthma, urticaria, or allergic reactions after taking NSAIDs.
- Active gastrointestinal bleeding or ulcers.
- Severe liver or kidney impairment.
Advice From The Pharmacist
- Take Naproxen Sodium ER exactly as prescribed, and do not exceed the recommended dose.
- It can be taken with food to minimize gastrointestinal discomfort.
- Monitor for signs of gastrointestinal bleeding, such as black or bloody stools.
Side Effects of Naproxen Sodium ER
Common Side Effects
- Gastrointestinal upset (nausea, vomiting, diarrhea)
- Headache
- Dizziness
- Rash or itching
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Gastrointestinal bleeding or ulcers
- Kidney problems (decreased urine output, swelling)
Risks and Warnings of Naproxen Sodium ER
- Cardiovascular Risk: Long-term use of NSAIDs may increase the risk of heart attack or stroke, particularly in individuals with existing heart conditions.
- Gastrointestinal Risks: Monitor for signs of gastrointestinal bleeding, especially in older adults or those with a history of ulcers.
Interactions with Naproxen Sodium ER
Common Drug Interactions
- Anticoagulants: Increased risk of bleeding when combined with blood thinners.
- Other NSAIDs: Avoid concurrent use with other NSAIDs to reduce gastrointestinal risk.
Alternatives to Naproxen Sodium ER
- Other NSAIDs: Such as ibuprofen or diclofenac for similar indications.
- Non-NSAID Pain Relievers: Such as acetaminophen for milder pain management.
