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MoviPrep

MoviPrep (generic name: polyethylene glycol electrolyte solution) is a bowel preparation medication used to cleanse the colon before a colonoscopy. It works as an osmotic laxative, drawing water into the colon to induce bowel movements and flush out the intestines. MoviPrep is typically prescribed before a colonoscopy to ensure that the colon is clear, allowing the doctor to get a better view during the procedure.

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Frequently Asked Questions

How long does it take for MoviPrep to start working?
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MoviPrep typically starts to work within 1 to 2 hours after taking the first dose, causing bowel movements.

Can I drink alcohol while taking MoviPrep?
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No, you should avoid alcohol while taking MoviPrep, as it can contribute to dehydration.

What should I do if I can’t finish the full dose of MoviPrep?
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If you have difficulty finishing the full dose, try drinking the solution more slowly or refrigerating it to make it easier to consume. If you still cannot finish it, contact your healthcare provider.

Can I take my regular medications while using MoviPrep?
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You may be able to take your regular medications, but you should check with your healthcare provider first. Some medications may need to be stopped temporarily before the colonoscopy, especially if they affect kidney function or hydration levels.

Can I refrigerate MoviPrep after mixing it?
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Yes, you can refrigerate the mixed solution to make it easier to drink. Cold liquids are often more palatable.

Comprehensive Drug Guide

How Does MoviPrep Work?

MoviPrep works by drawing water into the colon, which softens stools and stimulates bowel movements. The active ingredient, polyethylene glycol (PEG 3350), along with electrolytes, induces a large volume of watery diarrhea, which clears out the colon. The additional electrolytes (sodium, potassium, and others) help maintain the body’s balance of fluids and electrolytes during the bowel cleansing process.

Common Dosages

  • 2-liter preparation taken in two doses (1 liter each), typically combined with additional clear liquids.

Typical Dosing

MoviPrep is usually taken in the following schedule:

  • Evening-before dosing: Mix the first dose (one Pouch A and one Pouch B) with water to make 1 liter, drink the full liter over an hour (about 8 ounces every 15 minutes). Follow this with 16 ounces of clear liquids.
  • Morning-of dosing: Repeat the process with the second dose the next morning (same instructions as the first dose).

Typical Dosing

FDA Approved Indications

  • Bowel cleansing prior to a colonoscopy in adults.

Who Shouldn't Take MoviPrep?

  • Known hypersensitivity to any of the ingredients.
  • Gastrointestinal obstruction, bowel perforation, or paralytic ileus.
  • Toxic megacolon or severe inflammatory bowel disease.
  • Severe dehydration.

Advice From The Pharmacist

  • MoviPrep should be taken exactly as directed, with each dose mixed with water and consumed over 1 hour. It is important to drink the additional clear liquids (16 ounces) after each dose to ensure proper bowel cleansing.
  • Stay close to a bathroom after starting MoviPrep, as it will cause frequent, urgent bowel movements.
  • Clear liquids allowed during the prep period include water, clear broth, apple juice, or clear soda. Avoid any red or purple liquids, as they can affect the results of the colonoscopy.
  • Do not eat solid food while taking MoviPrep or during the preparation process. Stick to clear liquids only.
  • Store MoviPrep at room temperature, and refrigerate the prepared solution if desired, as cold liquids may be easier to drink.

Side Effects of MoviPrep

Common Side Effects

  • Nausea or vomiting
  • Bloating or abdominal discomfort
  • Diarrhea
  • Chills
  • Dehydration

Uncommon/Severe Side Effects

  • Electrolyte imbalances (symptoms include dizziness, muscle cramps, or confusion)
  • Severe dehydration
  • Heart rhythm disturbances

Risks and Warnings of MoviPrep

  • Electrolyte Imbalance: MoviPrep can cause significant fluid and electrolyte loss. Patients with conditions like heart failure, kidney disease, or who are on medications that affect electrolyte balance (e.g., diuretics) should use MoviPrep with caution and under close medical supervision.
  • Dehydration: Drinking sufficient clear liquids during the prep process is crucial to prevent dehydration. Watch for signs like dizziness, weakness, or dark urine.
  • Allergic Reactions: Rare allergic reactions may occur. Seek medical help if you experience symptoms like rash, swelling, or difficulty breathing.

Interactions with MoviPrep

Common Drug Interactions

  • Diuretics (e.g., furosemide): May increase the risk of electrolyte imbalances when combined with MoviPrep.
  • NSAIDs (e.g., ibuprofen, naproxen): These medications may increase the risk of kidney problems when used with MoviPrep, especially in patients with pre-existing kidney issues.
  • ACE inhibitors or ARBs: These medications, used for blood pressure control, may also increase the risk of kidney dysfunction or electrolyte imbalances when used with MoviPrep.

Alternatives to MoviPrep

  • GoLYTELY: Another polyethylene glycol-electrolyte solution used for bowel preparation.
  • Suprep: A different type of bowel prep solution, using sodium sulfate, potassium sulfate, and magnesium sulfate.
  • Prepopik: A low-volume bowel prep that contains sodium picosulfate and magnesium oxide.