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Lyumjev
Lyumjev is a rapid-acting insulin used to improve blood sugar control in people with diabetes mellitus, including both type 1 and type 2 diabetes. The active ingredient in Lyumjev is insulin lispro-aabc, a modified version of human insulin that works more quickly than regular insulin to help manage blood sugar levels around mealtimes. It is often used in combination with long-acting insulin or other diabetes medications to provide better overall glucose control. Lyumjev is designed to be injected right before meals or within 20 minutes after eating, helping prevent post-meal blood sugar spikes.
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Frequently Asked Questions
How quickly does Lyumjev start working?
Lyumjev begins to work within 15 minutes of injection, helping to manage blood sugar levels after meals more effectively than regular insulin.
Can I use Lyumjev in my insulin pump?
Yes, Lyumjev is approved for use in insulin pumps. Consult your healthcare provider for proper settings and usage instructions with your pump.
Can I use Lyumjev in my insulin pump?
Yes, Lyumjev is approved for use in insulin pumps. Consult your healthcare provider for proper settings and usage instructions with your pump.
What should I do if I miss a dose of Lyumjev?
If you miss a dose of Lyumjev, take it as soon as you remember if it is still around mealtime. If it’s too far from your meal, monitor your blood sugar closely and follow your healthcare provider’s instructions for adjusting future doses.
Can I use Lyumjev with long-acting insulin?
Yes, Lyumjev is typically used alongside long-acting insulin (such as Lantus or Toujeo) to provide both basal (long-term) and bolus (mealtime) insulin coverage.
Can I use Lyumjev with long-acting insulin?
Yes, Lyumjev is typically used alongside long-acting insulin (such as Lantus or Toujeo) to provide both basal (long-term) and bolus (mealtime) insulin coverage.
Can Lyumjev cause weight gain?
Like other insulins, Lyumjev can cause weight gain as it improves blood sugar control. Weight gain is a common side effect of insulin therapy, especially in patients who experience frequent hypoglycemia.
Can Lyumjev cause weight gain?
Like other insulins, Lyumjev can cause weight gain as it improves blood sugar control. Weight gain is a common side effect of insulin therapy, especially in patients who experience frequent hypoglycemia.
Comprehensive Drug Guide
How Does Lyumjev Work?
Lyumjev contains insulin lispro-aabc, which helps lower blood glucose levels by facilitating the uptake of glucose into tissues, such as muscle and fat cells, and inhibiting glucose production by the liver. Lyumjev is designed to act faster than other rapid-acting insulins due to the addition of excipients that accelerate insulin absorption. This makes it more effective at controlling postprandial (after-meal) blood sugar levels.
Common Dosages
- Lyumjev 100 units/mL in vials, prefilled pens, and cartridges
- Lyumjev 200 units/mL in prefilled pens for patients requiring higher doses of insulin
Typical Dosing
- Lyumjev is typically injected at the start of a meal or within 20 minutes after starting a meal.
- The dose of Lyumjev is individualized based on the patient's blood glucose monitoring, dietary intake, physical activity, and concurrent use of other diabetes medications.
- Adjustments in dosing may be required based on blood glucose readings or changes in lifestyle.
Typical Dosing
FDA Approved Indications
- Improving glycemic control in adults with type 1 and type 2 diabetes mellitus.
Who Shouldn't Take Lyumjev?
- Hypersensitivity to insulin lispro-aabc or any of the components in the formulation.
- Hypoglycemia (low blood sugar): If blood sugar levels are already low, administering Lyumjev may worsen hypoglycemia.
Advice From The Pharmacist
- Administer Lyumjev via subcutaneous injection immediately before meals or within 20 minutes of eating to ensure effective blood sugar control.
- Rotate injection sites to avoid skin irritation or lipodystrophy (abnormal fat distribution at injection sites).
- Regularly monitor blood glucose levels and adjust your insulin dose as advised by your healthcare provider.
- Always check the insulin for particles or discoloration before injecting. If the solution appears cloudy or contains particles, do not use it.
- Store unopened vials, pens, and cartridges in the refrigerator, but once opened, they can be kept at room temperature for up to 28 days.
Side Effects of Lyumjev
Common Side Effects
- Hypoglycemia (low blood sugar), which may present as sweating, dizziness, shakiness, or confusion.
- Injection site reactions (redness, itching, or swelling).
- Weight gain (common with insulin therapy).
- Lipodystrophy (changes in fat tissue at the injection site).
Uncommon/Severe Side Effects
- Severe hypoglycemia, which can lead to unconsciousness or seizures.
- Allergic reactions, including rash, itching, swelling, or difficulty breathing.
- Hypokalemia (low potassium levels), which can lead to muscle weakness or irregular heartbeat.
Risks and Warnings of Lyumjev
- Hypoglycemia Risk: Lyumjev can cause low blood sugar levels, particularly if meals are delayed or skipped. Always carry a fast-acting carbohydrate (like glucose tablets or juice) in case of hypoglycemia.
- Driving and Operating Machinery: Be cautious when driving or operating heavy machinery, as hypoglycemia can impair your ability to focus.
- Insulin Sensitivity: Exercise, changes in diet, or illness can affect how your body responds to insulin, so regular monitoring of blood sugar levels is essential.
- Allergic Reactions: Severe allergic reactions to insulin are rare but can occur. If you experience difficulty breathing, swelling, or severe itching, seek medical attention immediately.
Interactions with Lyumjev
Common Drug Interactions
- Oral antidiabetic drugs (e.g., metformin, sulfonylureas): Combining these with Lyumjev can increase the risk of hypoglycemia.
- Beta-blockers: These medications can mask the signs of hypoglycemia, making it harder to detect low blood sugar.
- ACE inhibitors and ARBs: These can increase insulin sensitivity, potentially leading to hypoglycemia.
- Corticosteroids: Medications like prednisone can increase blood sugar levels, requiring adjustments in insulin dosing.
Alternatives to Lyumjev
- Humalog (insulin lispro): Another rapid-acting insulin similar to Lyumjev, but with a slightly slower onset.
- Novolog (insulin aspart): A rapid-acting insulin that works similarly to Lyumjev.
- Fiasp (faster-acting insulin aspart): An ultra-rapid-acting insulin similar to Lyumjev, with an even quicker onset of action.
- Apidra (insulin glulisine): Another rapid-acting insulin used for mealtime blood sugar control.
