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Lidotral

Lidotral is a topical anesthetic cream or gel that contains lidocaine and prilocaine, both of which are local anesthetics. It is primarily used to numb the skin before certain medical procedures, such as injections, minor surgeries, tattoo removal, or laser treatments. Lidotral works by blocking nerve signals in the area where it is applied, providing localized pain relief for procedures that might otherwise cause discomfort.

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Frequently Asked Questions

How long does it take for Lidotral to start working?
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Lidotral typically begins to numb the skin within 30 to 60 minutes after application. For deeper numbing, it is often left on for up to 2 hours before the procedure.

How long does the numbing effect last?
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The numbing effect of Lidotral can last for 1 to 2 hours after the cream is removed. The exact duration depends on the area treated and how long the cream was applied.

Can Lidotral be used for pain relief after a procedure?
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Lidotral is intended for use before procedures to prevent pain. It is not typically used for pain relief after a procedure, as its numbing effect wears off after a few hours.

What should I do if I experience skin irritation?
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If you experience mild skin irritation, wash the area with soap and water and avoid further use of Lidotral. If the irritation is severe or persists, discontinue use and contact your healthcare provider.

Is Lidotral safe for children?
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Lidotral can be used in children, but the dose and application time should be carefully adjusted based on the child's age, weight, and the area being treated. Always follow your healthcare provider's recommendations for pediatric use.

Comprehensive Drug Guide

How Does Lidotral Work?

Lidotral contains lidocaine and prilocaine, both of which work by inhibiting sodium channels in nerve cells. This prevents the nerves from sending pain signals to the brain, numbing the area of application. By blocking the transmission of nerve signals, Lidotral provides temporary localized pain relief, making medical procedures more comfortable.

Common Dosages

  • Cream or gel: Apply a thick layer to the skin 1-2 hours before the procedure.
  • Patch: Apply the patch to the skin 30 minutes to 1 hour before the procedure, depending on the area and procedure.

Typical Dosing

  • For minor procedures (such as injections or blood draws), apply 1-2 grams of cream to the affected area at least 1 hour before the procedure.
  • For larger areas, more cream may be used, and the application time may be extended up to 2 hours before the procedure to achieve maximum numbing.
  • For children, the dosage and application time should be adjusted according to their weight and the area to be treated, under the guidance of a healthcare provider.

Typical Dosing

FDA Approved Indications

  • Topical anesthesia before minor surgical procedures, injections, or blood draws
  • Numbing the skin before cosmetic treatments such as laser hair removal or tattoo removal
  • Minor skin procedures, including the treatment of leg ulcers and superficial wounds

Who Shouldn't Take Lidotral?

  • Known hypersensitivity or allergy to lidocaine, prilocaine, or other amide-type local anesthetics.
  • Severe liver disease, as it can affect the metabolism of the anesthetic.
  • Methemoglobinemia, a rare blood condition that can be exacerbated by prilocaine.

Advice From The Pharmacist

  • Apply Lidotral to clean, dry skin. Make sure to follow the specific instructions given by your healthcare provider regarding how much to use and how long to leave it on.
  • After applying Lidotral, it may be covered with an occlusive dressing (like plastic wrap) to increase absorption and effectiveness. Be sure to remove this dressing and the cream or gel before the procedure.
  • Avoid applying Lidotral to open wounds, severely damaged skin, or areas with infection, unless instructed by your healthcare provider.
  • Wash your hands thoroughly after applying Lidotral to avoid accidental numbness of other areas (e.g., eyes or mouth).
  • If any skin irritation or allergic reaction occurs, stop using Lidotral and consult your healthcare provider.

Side Effects of Lidotral

Common Side Effects

  • Mild redness or swelling at the application site
  • Itching or tingling in the area where the cream was applied
  • Numbness that may persist for a few hours after the procedure

Uncommon/Severe Side Effects

  • Severe skin irritation or blistering
  • Allergic reactions (rash, itching, swelling, trouble breathing)
  • Methemoglobinemia: Symptoms include blue or gray skin, headache, or shortness of breath, and occur more commonly in patients with underlying conditions or prolonged use.

Risks and Warnings of Lidotral

  • Methemoglobinemia: Prilocaine, one of the active ingredients in Lidotral, can rarely cause methemoglobinemia, a condition where the blood is less able to carry oxygen. If you notice symptoms like blue lips or skin, confusion, or difficulty breathing, seek medical attention immediately.
  • Skin Reactions: Lidotral may cause local skin irritation or allergic reactions, particularly with prolonged use. Discontinue use and contact your healthcare provider if significant irritation or blistering occurs.
  • Systemic Absorption: If Lidotral is used in large amounts or for prolonged periods, there is a risk of systemic absorption, which can cause symptoms such as dizziness, nausea, or irregular heartbeat.

Interactions with Lidotral

Common Drug Interactions

  • Class I antiarrhythmics (e.g., mexiletine): Using Lidotral with other local anesthetics or medications that affect the heart’s rhythm may increase the risk of adverse effects.
  • Other topical anesthetics: Avoid using Lidotral alongside other numbing agents, as this may increase the risk of systemic absorption and toxicity.
  • Beta-blockers: These medications can reduce the body’s ability to metabolize lidocaine, increasing the risk of side effects.

Alternatives to Lidotral

  • EMLA Cream: A similar topical anesthetic cream containing the same active ingredients (lidocaine and prilocaine) for use before minor procedures.
  • Lidocaine-only creams or gels: Available in over-the-counter and prescription forms for pain relief and numbing of the skin.
  • Topical benzocaine: A local anesthetic used for temporary relief of pain or discomfort associated with minor burns, sunburn, insect bites, and other conditions.