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Lexette
Lexette is the brand name for halobetasol propionate, a super high-potency corticosteroid used topically to treat plaque psoriasis in adults. It helps reduce the redness, swelling, and itching associated with inflammatory skin conditions like psoriasis. Lexette is typically prescribed for short-term use due to its potency, and it is available in a unique foam formulation, making it easy to apply and allowing it to absorb quickly into the skin.
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Frequently Asked Questions
How long can I use Lexette?
Lexette is typically prescribed for up to 2 weeks. Prolonged use increases the risk of skin thinning and other side effects. Always follow your doctor's instructions regarding duration of use.
Can I use Lexette on my face?
Lexette should generally not be used on the face, groin, or underarms due to the higher risk of side effects like skin thinning. Consult your doctor before applying it to these areas.
What should I do if I miss a dose of Lexette?
If you miss a dose, apply it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I use Lexette for conditions other than psoriasis?
Lexette is primarily prescribed for plaque psoriasis. It should not be used for other conditions without your doctor’s approval, as it may not be appropriate for other skin issues.
What should I do if I experience skin irritation with Lexette?
If you experience severe irritation, redness, or allergic reactions, stop using Lexette and contact your healthcare provider for further advice.
Comprehensive Drug Guide
How Does Lexette Work?
Lexette works by activating glucocorticoid receptors in the skin, which helps suppress the immune response that causes inflammation. This leads to a reduction in the redness, swelling, itching, and scaling associated with plaque psoriasis. By decreasing the production of pro-inflammatory substances like prostaglandins and cytokines, it helps control the overactive immune response seen in psoriasis.
Common Dosages
- The typical dose is a thin layer applied once or twice daily to the affected areas of the skin.
Typical Dosing
- For plaque psoriasis: Apply a thin layer of Lexette foam to the affected areas once or twice daily as directed by your healthcare provider. The treatment duration is usually limited to 2 weeks, and the total amount used should not exceed 50 grams per week.
Typical Dosing
FDA Approved Indications
- Treatment of plaque psoriasis in adults.
Who Shouldn't Take Lexette?
- Known hypersensitivity or allergy to halobetasol or any component of the formulation.
- Viral, fungal, or bacterial skin infections that are untreated, as corticosteroids can worsen infections.
Advice From The Pharmacist
- Apply a thin layer of Lexette foam to the affected areas, rubbing it in gently. Avoid using it on the face, groin, underarms, or broken skin, unless directed by your doctor.
- Do not use for longer than 2 weeks unless prescribed by your doctor, as prolonged use of high-potency corticosteroids can lead to skin thinning and other side effects.
- Do not cover or bandage the treated area unless instructed to do so by your doctor, as this may increase the absorption of the medication and raise the risk of side effects.
- Wash your hands after applying Lexette unless you are treating your hands.
- Store Lexette at room temperature, away from heat and direct sunlight, and do not puncture or burn the foam container, even when empty.
Side Effects of Lexette
Common Side Effects
- Burning or stinging at the application site
- Itching
- Dryness
- Redness
Uncommon/Severe Side Effects
- Skin thinning (atrophy) with long-term use
- Stretch marks (striae)
- Increased risk of infections at the application site
- Systemic absorption, leading to signs of Cushing’s syndrome, such as weight gain, facial swelling, and increased blood pressure
Risks and Warnings of Lexette
- Skin Thinning (Atrophy): Prolonged use of high-potency corticosteroids like Lexette can cause thinning of the skin, especially when used on sensitive areas like the face or groin. Limit use to 2 weeks unless otherwise directed by your doctor.
- Systemic Absorption: In rare cases, Lexette can be absorbed into the bloodstream, especially when used over large areas or under occlusive dressings. This can lead to systemic corticosteroid side effects such as Cushing’s syndrome or adrenal suppression.
- Growth Suppression in Children: Long-term use of high-potency corticosteroids in children may cause growth suppression. Lexette should not be used in children unless prescribed by a healthcare provider.
Interactions with Lexette
Common Drug Interactions
- Topical corticosteroids: Using multiple corticosteroid products can increase the risk of skin thinning and systemic side effects.
- Immunosuppressive agents: Combining Lexette with immunosuppressive drugs can increase the risk of infections and other side effects.
Alternatives to Lexette
- Clobetasol propionate: Another super high-potency corticosteroid used to treat severe inflammatory skin conditions.
- Betamethasone dipropionate: A high-potency corticosteroid used for similar indications, available in various topical formulations.
- Calcipotriene (Dovonex): A non-steroidal treatment for psoriasis, often used in combination with corticosteroids.
- Tacrolimus (Protopic): A topical immunosuppressant used for inflammatory skin conditions when corticosteroids are not recommended.
