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Kexm
Kexm, the brand name for dapoxetine, is a medication used primarily for the treatment of premature ejaculation (PE) in men aged 18 to 64 years. Dapoxetine is classified as a selective serotonin reuptake inhibitor (SSRI) and is the first medication specifically approved for the treatment of PE. It helps to increase the time it takes to ejaculate and improves control over ejaculation, enhancing sexual satisfaction for both the individual and their partner.
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Frequently Asked Questions
How long does it take for Kexm to work?
Kexm typically begins to work within 1 to 3 hours after taking the dose.
Can I take Kexm every day?
Kexm is intended for as-needed use before sexual activity and should not be taken more than once every 24 hours.
What should I do if I miss a dose of Kexm?
If you miss a dose, do not take a double dose. Simply take the next dose as scheduled before your next sexual activity.
Can I take Kexm with other medications?
Inform your healthcare provider about all medications you are taking to avoid potential interactions, especially other SSRIs or medications affecting serotonin.
Is Kexm safe to use long-term?
Kexm is generally considered safe for long-term use under medical supervision, but regular follow-up with your healthcare provider is important to monitor for any side effects or complications.
Comprehensive Drug Guide
How Does Kexm Work?
Dapoxetine works by inhibiting the reuptake of serotonin in the brain, leading to increased serotonin levels in the synaptic cleft. This enhancement of serotonin signaling is thought to delay ejaculation and increase the time to ejaculation during sexual activity. Unlike traditional SSRIs, which are often used to treat depression, dapoxetine is rapidly absorbed and eliminated from the body, allowing it to be taken on an as-needed basis before sexual activity.
Common Dosages
- 30 mg and 60 mg tablets.
The usual starting dose is 30 mg, which may be increased to 60 mg depending on individual response and tolerability.
Typical Dosing
- For premature ejaculation: The typical starting dose is 30 mg taken 1 to 3 hours before anticipated sexual activity. If necessary, the dose may be increased to 60 mg based on the patient’s response. Dapoxetine should not be taken more than once in a 24-hour period.
Typical Dosing
FDA Approved Indications
- Treatment of premature ejaculation (PE) in men aged 18 to 64 years.
Who Shouldn't Take Kexm?
- Known hypersensitivity or allergy to dapoxetine or any components of the formulation.
- Severe liver impairment.
- Cardiovascular conditions (e.g., heart failure, unstable angina, or arrhythmias).
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or other SSRIs due to the risk of serotonin syndrome.
Advice From The Pharmacist
- Take Kexm as prescribed: Follow the dosage instructions provided by your healthcare provider and do not exceed the recommended dose.
- Timing: Take Kexm 1 to 3 hours before sexual activity for the best results. It should not be taken more than once in a 24-hour period.
- Avoid alcohol: Alcohol can increase the risk of side effects, such as dizziness or fainting, so it is best to limit or avoid alcohol consumption while using Kexm.
- Inform your doctor about any other medications you are taking to avoid potential interactions.
Side Effects of Kexm
Common Side Effects
- Nausea
- Dizziness
- Headache
- Diarrhea
- Fatigue
- Dry mouth
Uncommon/Severe Side Effects
- Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
- Serotonin syndrome, which can cause confusion, agitation, rapid heart rate, and increased blood pressure.
Risks and Warnings of Kexm
- Cardiovascular Risks: Dapoxetine can cause a decrease in blood pressure, especially when standing up (orthostatic hypotension). Patients should be cautious when transitioning from sitting or lying down to standing.
- Serotonin Syndrome: Use caution if you are taking other medications that affect serotonin levels, as this can increase the risk of serotonin syndrome, a potentially life-threatening condition.
- Potential for Misuse: Dapoxetine is not intended for use as a recreational drug, and misuse can lead to adverse effects and dependency.
Interactions with Kexm
Common Drug Interactions
- Other SSRIs or SNRIs: Combining these medications can increase the risk of serotonin syndrome.
- MAOIs: Concurrent use can lead to severe interactions and should be avoided.
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): These can increase the levels of dapoxetine in the blood, potentially leading to increased side effects.
Alternatives to Kexm
- Selective serotonin reuptake inhibitors (SSRIs): Other SSRIs, such as paroxetine or sertraline, may also be prescribed off-label for premature ejaculation.
- Topical anesthetics: Creams or sprays containing lidocaine or prilocaine may be applied to the penis to reduce sensitivity and help delay ejaculation.
- Behavioral therapies: Techniques such as the stop-start method or squeeze technique can help manage premature ejaculation.
