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Imitrex STATdose System

Imitrex STATdose System (sumatriptan) is a triptan medication used for the acute treatment of migraine attacks in adults. It is designed to provide rapid relief of migraine symptoms, including headache, nausea, and sensitivity to light and sound. The STATdose System features a pre-filled autoinjector, allowing for easy and convenient self-administration.



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Frequently Asked Questions

How long does it take for Imitrex STATdose System to start working?
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Patients may begin to feel relief within 10 to 20 minutes after injection, with peak effects occurring within 1 to 2 hours.

Can I take Imitrex STATdose System with other medications?
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Always consult your healthcare provider before combining Imitrex with other medications, especially other migraine treatments.

What should I do if I miss a dose of Imitrex STATdose System?
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Imitrex is intended for use at the onset of a migraine. If you miss a dose during an attack, administer it as soon as you remember, but do not exceed the maximum recommended daily dose.

Is it safe to use Imitrex STATdose System during pregnancy?
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Imitrex should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Is it safe to use Imitrex STATdose System during pregnancy?
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Imitrex should be used during pregnancy only if clearly needed, and the risks and benefits should be discussed with a healthcare provider.

Can Imitrex STATdose System cause weight gain?
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Weight gain is not a common side effect of Imitrex. However, any significant changes in weight should be discussed with a healthcare provider.

Comprehensive Drug Guide

How Does Imitrex STATdose System Work?

Sumatriptan works by selectively agonizing serotonin (5-HT) receptors in the brain, particularly the 5-HT1B and 5-HT1D subtypes. This action causes vasoconstriction of cranial blood vessels and inhibits the release of pro-inflammatory neuropeptides, alleviating migraine symptoms.



Common Dosages

  • Injection: Typically 6 mg of sumatriptan per autoinjector.

Typical Dosing

  • The recommended dose for adults is 6 mg administered subcutaneously at the onset of a migraine attack. If symptoms do not improve after 1 hour, a second dose may be administered, but the total daily dose should not exceed 12 mg.


Typical Dosing

FDA Approved Indications

Acute treatment of migraine attacks with or without aura.

Who Shouldn't Take Imitrex STATdose System?

  • Known hypersensitivity to sumatriptan or any components of the formulation
  • History of ischemic heart disease, coronary artery disease, or uncontrolled hypertension
  • Severe hepatic impairment


Advice From The Pharmacist

  • Patients should be educated on the proper technique for using the autoinjector to ensure effective delivery of the medication.
  • Advise patients to seek medical attention if they experience chest pain, tightness, or other concerning symptoms after administration.
  • Patients should be informed that Imitrex is intended for the treatment of acute migraine attacks and not for preventive therapy.


Side Effects of Imitrex STATdose System

Common Side Effects

  • Injection site reactions (redness, swelling, pain)
  • Dizziness
  • Drowsiness
  • Nausea
  • Sensations of tingling or warmth


Uncommon/Severe Side Effects

  • Chest pain or tightness
  • Severe allergic reactions (anaphylaxis)
  • Serotonin syndrome (especially if combined with other serotonergic agents)


Risks and Warnings of Imitrex STATdose System

  • Cardiovascular Risk: Monitor for signs of cardiovascular events, especially in patients with a history of heart disease.
  • Medication Overuse Headache: Frequent use of Imitrex can lead to rebound headaches; limit usage according to healthcare provider recommendations.


Interactions with Imitrex STATdose System

Common Drug Interactions

  • Other Triptans: Use caution when using Imitrex with other triptan medications to avoid increased risk of adverse effects.
  • Monoamine Oxidase Inhibitors (MAOIs): Concomitant use may increase the risk of sumatriptan toxicity.


Alternatives to Imitrex STATdose System

  • Other Triptans: Such as rizatriptan or zolmitriptan for acute migraine treatment.
  • Ergotamine derivatives: For migraine management.
  • Non-steroidal anti-inflammatory drugs (NSAIDs): Such as ibuprofen for mild to moderate migraine relief.