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HumuLIN R U-500 (CONCENTRATED)
HumuLIN R U-500 is a concentrated form of insulin used for the management of diabetes mellitus in patients who require a higher dose of insulin. It is particularly beneficial for individuals with insulin resistance who may not achieve adequate glycemic control with standard insulin dosages. This formulation is available in a 500 units/mL concentration, making it five times more concentrated than regular U-100 insulin.
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Frequently Asked Questions
How long does it take for HumuLIN R U-500 to start working?
HumuLIN R U-500 typically starts to lower blood glucose levels within 30 minutes after injection, with peak effects occurring between 2 to 4 hours.
Can I take HumuLIN R U-500 with other medications?
Always consult your healthcare provider before combining HumuLIN R U-500 with other medications, especially other insulin or oral antidiabetic agents.
What should I do if I miss a dose of HumuLIN R U-500?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use HumuLIN R U-500 during pregnancy?
HumuLIN R U-500 may be used during pregnancy if clearly needed, but the risks and benefits should be discussed with a healthcare provider.
Can HumuLIN R U-500 cause weight gain?
Weight gain can occur as a side effect of insulin therapy, so patients should monitor their weight and discuss any concerns with their healthcare provider.
Comprehensive Drug Guide
How Does HumuLIN R U-500 (CONCENTRATED) Work?
HumuLIN R U-500 acts by facilitating the uptake of glucose into muscle and fat cells and inhibiting hepatic glucose production. It lowers blood sugar levels by mimicking the body’s natural insulin response, allowing cells to use glucose for energy.
Common Dosages
- Vial: 500 units/mL.
Typical Dosing
- The dosing of HumuLIN R U-500 is individualized based on blood glucose levels, diet, and physical activity. The typical starting dose may be 50-100% of the patient's total daily insulin requirement.
- Dosing should be carefully calculated, with close monitoring of blood glucose levels to avoid hypoglycemia.
Typical Dosing
FDA Approved Indications
- Management of diabetes mellitus in patients who require more than 200 units of insulin per day.
Who Shouldn't Take HumuLIN R U-500 (CONCENTRATED)?
- Known hypersensitivity to insulin or any components of the formulation
- Episodes of hypoglycemia (low blood sugar)
Advice From The Pharmacist
- Patients should be educated on the proper technique for insulin injection, including site rotation to prevent lipodystrophy.
- Monitor blood glucose regularly to ensure the medication is effective and to make any necessary dose adjustments.
- Store unused vials in the refrigerator and allow them to reach room temperature before use.
Side Effects of HumuLIN R U-500 (CONCENTRATED)
Common Side Effects
- Hypoglycemia (low blood sugar)
- Injection site reactions (redness, swelling, pain)
- Weight gain
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Hypoglycemic unawareness (difficulty recognizing symptoms of low blood sugar)
Risks and Warnings of HumuLIN R U-500 (CONCENTRATED)
- Hypoglycemia: Patients must be educated on recognizing the symptoms of low blood sugar and how to treat it promptly.
- Allergic Reactions: Monitor for signs of severe allergic reactions and report any such symptoms to a healthcare provider.
- Dosing Adjustments: Doses may need to be adjusted based on changes in diet, exercise, or illness.
Interactions with HumuLIN R U-500 (CONCENTRATED)
Common Drug Interactions
- Other Antidiabetic Medications: Careful monitoring is required when using HumuLIN R U-500 with other diabetes medications to avoid hypoglycemia.
- Beta-Blockers: These medications may mask the symptoms of hypoglycemia.
- Alcohol: Should be consumed with caution, as it can increase the risk of hypoglycemia.
Alternatives to HumuLIN R U-500 (CONCENTRATED)
- HumuLIN R U-100: The standard formulation for patients who do not require high doses.
- Insulin Glargine (Lantus): A long-acting insulin that may be used for basal control.
- Insulin Detemir (Levemir): Another long-acting insulin option for diabetes management.
