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HumaLOG Mix 50/50
HumaLOG Mix 50/50 is an insulin combination therapy that contains both insulin lispro (a rapid-acting insulin) and insulin lispro protamine (an intermediate-acting insulin). This formulation is designed to provide both quick and prolonged insulin action, making it suitable for individuals with diabetes who require both mealtime insulin coverage and basal control. HumaLOG Mix 50/50 helps to control blood sugar levels throughout the day, particularly around meal times.
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Frequently Asked Questions
How long does it take for HumaLOG Mix 50/50 to start working?
Insulin lispro starts to lower blood glucose levels within 15 minutes, while the protamine component extends the action for more prolonged coverage.
Can I take HumaLOG Mix 50/50 with other medications?
Always consult your healthcare provider before combining HumaLOG Mix 50/50 with other medications, especially other insulin or oral antidiabetic agents.
What should I do if I miss a dose of HumaLOG Mix 50/50?
If you miss a dose, take it as soon as you remember if it's before a meal. If it’s close to your next meal, skip the missed dose and continue with your regular schedule. Do not double the dose.
Is it safe to use HumaLOG Mix 50/50 during pregnancy?
HumaLOG Mix 50/50 may be used during pregnancy if clearly needed, but the risks and benefits should be discussed with a healthcare provider.
Can HumaLOG Mix 50/50 cause weight gain?
Weight gain can occur as a side effect of insulin therapy, so patients should monitor their weight and discuss any concerns with their healthcare provider.
Comprehensive Drug Guide
How Does HumaLOG Mix 50/50 Work?
HumaLOG Mix 50/50 combines the rapid action of insulin lispro, which begins to lower blood glucose levels within minutes of injection, with the intermediate action of insulin lispro protamine, which provides a more sustained release. This combination allows for effective management of postprandial (after-meal) blood sugar spikes as well as providing a baseline level of insulin to control blood sugar levels throughout the day.
Common Dosages
OG Mix 50/50 is available in the following formulations:
- Pre-filled pens: Each pen typically contains 100 units/mL in a 3 mL cartridge.
- Vials: Available in similar concentrations for manual dosing.
Typical Dosing
- The dosing of HumaLOG Mix 50/50 is individualized based on the patient's blood glucose levels, diet, and physical activity.
- It is usually administered 30 minutes before meals, with dosages adjusted as necessary to achieve optimal blood glucose control.
Typical Dosing
FDA Approved Indications
- The management of diabetes mellitus in adults and children.
Who Shouldn't Take HumaLOG Mix 50/50?
- Known hypersensitivity to insulin lispro or any components of the formulation
- Episodes of hypoglycemia (low blood sugar)
Advice From The Pharmacist
- Patients should be trained in proper injection techniques and site rotation to minimize injection site reactions and lipodystrophy.
- Regular blood glucose monitoring is essential to determine the effectiveness of the insulin regimen and to adjust doses as needed.
- Store unused pens and vials in the refrigerator, but once in use, they can be kept at room temperature for up to 28 days.
Side Effects of HumaLOG Mix 50/50
Common Side Effects
- Hypoglycemia (low blood sugar)
- Injection site reactions (redness, swelling)
- Weight gain
Uncommon/Severe Side Effects
- Severe allergic reactions (anaphylaxis)
- Hypoglycemic unawareness (difficulty recognizing symptoms of low blood sugar)
Risks and Warnings of HumaLOG Mix 50/50
- Hypoglycemia: Patients must be educated on recognizing the symptoms of low blood sugar and how to treat it promptly.
- Allergic Reactions: Monitor for signs of severe allergic reactions and report any such symptoms to a healthcare provider.
- Dosing Adjustments: Doses may need to be adjusted based on changes in diet, exercise, or illness.
Interactions with HumaLOG Mix 50/50
Common Drug Interactions
- Other Antidiabetic Medications: Careful monitoring is required when using HumaLOG Mix 50/50 with other diabetes medications to avoid hypoglycemia.
- Beta-Blockers: These medications may mask the symptoms of hypoglycemia.
Common Food Interactions
- Alcohol: Alcohol can increase the risk of hypoglycemia and should be consumed with caution.
Alternatives to HumaLOG Mix 50/50
- Other Insulin Combinations: Such as HumaLOG Mix 75/25 or other premixed insulins.
- Basal Insulin with Bolus Insulin: Such as insulin glargine with insulin lispro or aspart for more individualized control.
- Continuous Glucose Monitors (CGMs): As part of a comprehensive diabetes management plan.
