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First-Progesterone VGS
First-Progesterone VGS contains progesterone, a natural hormone used to support reproductive health and manage conditions related to hormonal imbalances. It is commonly prescribed for women undergoing assisted reproductive technologies (ART), such as in vitro fertilization (IVF), to help prepare the uterus for pregnancy and support early pregnancy. It may also be used to treat progesterone deficiency, amenorrhea (absence of menstruation), and to support luteal phase deficiencies.
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Frequently Asked Questions
How long will I need to use First-Progesterone VGS for IVF?
The duration of use varies, but progesterone is typically continued through the first trimester of pregnancy to support the developing pregnancy.
Can I use First-Progesterone VGS during pregnancy?
Yes, First-Progesterone VGS is often used to support early pregnancy in women undergoing ART treatments like IVF. Always follow your healthcare provider’s instructions.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.
Are there any dietary restrictions while using First-Progesterone VGS?
No specific dietary restrictions are necessary, but it's important to maintain a healthy, balanced diet to support overall reproductive health.
Can First-Progesterone VGS cause mood changes?
Yes, some women experience mood swings or changes in mood while taking progesterone. If you experience significant mood changes, speak with your healthcare provider.
Comprehensive Drug Guide
How Does First-Progesterone VGS Work?
Progesterone is a hormone that plays a crucial role in the menstrual cycle and pregnancy. First-Progesterone VGS supplements natural progesterone levels in women who may not produce enough of the hormone. It helps prepare the lining of the uterus for implantation and supports the early stages of pregnancy by maintaining a suitable environment for embryo development.
Common Dosages
- For ART and luteal phase support: Insert 50-100 mg vaginally once or twice daily, starting after ovulation or embryo transfer and continuing through early pregnancy as prescribed.
- For secondary amenorrhea: The typical dose is 100-200 mg inserted vaginally daily for 6-12 days in a 28-day cycle, depending on the condition being treated.
Typical Dosing
FDA Approved Indications
- Progesterone supplementation or replacement in women with progesterone deficiency, including those undergoing ART treatments like IVF.
- Treatment of secondary amenorrhea (absence of menstrual periods).
- Support of luteal phase deficiency during ART or in natural cycles where progesterone levels are inadequate.
Who Shouldn't Take First-Progesterone VGS?
- Active thrombophlebitis or a history of blood clots.
- Severe liver disease.
- Known or suspected breast cancer or other hormone-sensitive cancers.
- Undiagnosed vaginal bleeding.
Advice From The Pharmacist
- Insert the suppository as directed, typically before bedtime to allow for better absorption while lying down. Wash your hands before and after use.
- Vaginal leakage of the suppository’s contents is common. You may want to wear a panty liner to prevent staining.
- Store the suppositories in a cool place, and do not expose them to excessive heat as they may melt.
- Continue taking First-Progesterone VGS as prescribed, even after a positive pregnancy test, unless otherwise directed by your healthcare provider.
Side Effects of First-Progesterone VGS
Common Side Effects
- Vaginal discharge or irritation
- Breast tenderness
- Mood swings
- Headache
- Bloating
Uncommon/Severe Side Effects
- Blood clots, which can present as pain, swelling, or redness in the legs, sudden shortness of breath, or chest pain.
- Severe allergic reactions (swelling of the face, tongue, or throat, difficulty breathing).
- Jaundice (yellowing of the skin or eyes).
Risks and Warnings of First-Progesterone VGS
- Blood Clots: Progesterone use increases the risk of thromboembolic events (blood clots). If you experience symptoms like leg pain, swelling, chest pain, or shortness of breath, seek immediate medical attention.
- Hormone-sensitive cancers: Progesterone should be avoided in individuals with a history of breast cancer, uterine cancer, or other hormone-dependent tumors.
- Liver Function: Progesterone can affect liver function, especially with long-term use. Monitor for signs of jaundice or other liver issues.
Interactions with First-Progesterone VGS
Common Drug Interactions
- Estrogen therapy: Progesterone is often used in combination with estrogen in hormone replacement therapy (HRT), but the doses must be carefully adjusted to balance hormone levels.
- CYP450 enzyme inducers (e.g., rifampin, carbamazepine): These medications can reduce the effectiveness of progesterone by increasing its metabolism.
Alternatives to First-Progesterone VGS
- Crinone (progesterone vaginal gel): Another form of progesterone used in ART and for luteal phase support.
- Prometrium (progesterone capsules): An oral progesterone supplement used for similar purposes, including amenorrhea and hormonal support.
- Endometrin (progesterone vaginal inserts): A commonly used progesterone insert for luteal phase support in ART treatments.
