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Endometrin
Endometrin (progesterone) is a vaginal insert used as part of assisted reproductive technology (ART) treatments, such as in vitro fertilization (IVF). It helps prepare the uterine lining for the implantation of a fertilized egg and supports early pregnancy. Endometrin belongs to the class of progestins, which are hormones that mimic the action of natural progesterone.
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Frequently Asked Questions
Can I use Endometrin while breastfeeding?
Progesterone can be excreted in breast milk, but it’s generally considered safe for short-term use. Consult your doctor if you are breastfeeding.
How long should I use Endometrin after IVF?
Endometrin is typically used for up to 10 weeks of pregnancy, but your healthcare provider will give you specific guidance based on your situation.
What should I do if I miss a dose?
If you miss a dose of Endometrin, insert it as soon as you remember. If it’s close to the time for the next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Can Endometrin cause weight gain?
Some women may experience weight gain due to fluid retention while using Endometrin, but it is not a common side effect.
Is Endometrin safe for long-term use?
Endometrin is typically used short-term during ART cycles. Long-term use should be closely monitored by your healthcare provider due to the potential risk of hormone-related side effects.
Comprehensive Drug Guide
How Does Endometrin Work?
Endometrin works by mimicking the body’s natural progesterone, a hormone essential for maintaining pregnancy. It supports the thickening of the uterine lining, making it more receptive to the implantation of a fertilized egg and maintaining the pregnancy in the early stages.
What is Endometrin Used For?
Common Dosages
- Vaginal inserts: 100 mg
Typical Dosing
- The typical dose of Endometrin is 100 mg inserted vaginally two or three times a day, starting after egg retrieval and continuing for up to 10 weeks of pregnancy, or as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Supporting progesterone levels in women undergoing assisted reproductive technology (ART) treatments such as IVF.
Who Shouldn't Take Endometrin?
- Known hypersensitivity to progesterone or any of the insert components
- Undiagnosed vaginal bleeding
- Liver dysfunction or disease
- Known or suspected breast cancer
Advice From The Pharmacist
- Endometrin is a vaginal insert. Make sure to wash your hands before and after insertion.
- Lie down for a few minutes after inserting Endometrin to ensure proper absorption.
- Keep track of the dosing schedule, as missing doses may affect treatment outcomes.
Side Effects of Endometrin
Common Side Effects
- Vaginal irritation
- Headache
- Abdominal pain
- Breast tenderness
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Severe allergic reactions (swelling of the face, lips, or tongue)
Risks and Warnings of Endometrin
- Blood Clot Risk: Progesterone may increase the risk of blood clots. Seek medical help if you experience pain, swelling in the legs, or shortness of breath.
- Hormone-Sensitive Cancer Risk: Endometrin may increase the risk of breast or uterine cancer in women with a history of hormone-sensitive cancers.
Interactions with Endometrin
Common Drug Interactions
- CYP3A4 inducers (such as rifampin) may reduce the effectiveness of Endometrin.
- Avoid using Endometrin with other vaginal products at the same time, as it may affect absorption.
Alternatives to Endometrin
- Crinone (progesterone gel)
- Prometrium (oral progesterone capsules)
- Progesterone oil injections
