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Crinone
Crinone (progesterone gel) is a hormonal medication used primarily for progesterone supplementation or replacement in women undergoing fertility treatments, such as assisted reproductive technology (ART), and for the treatment of secondary amenorrhea (absence of menstrual periods). Progesterone is essential for preparing the lining of the uterus to support a pregnancy and maintain it during the early stages.
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Frequently Asked Questions
How long does it take for Crinone to start working?
Crinone begins to work as soon as it is absorbed, with its effects on the uterine lining supporting embryo implantation or addressing hormonal imbalances within a few days of starting treatment.
Can Crinone be used in early pregnancy?
Yes, Crinone is often used in the first trimester of pregnancy, especially in women undergoing fertility treatments, to help maintain the pregnancy.
What should I do if I miss a dose of Crinone?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Can Crinone cause mood changes?
Yes, mood swings and depressive symptoms are potential side effects of progesterone therapy. If these symptoms worsen, contact your healthcare provider.
How long can I use Crinone?
For fertility treatments, Crinone is typically used for the first 10 to 12 weeks of pregnancy. Your healthcare provider will guide you on how long to continue therapy based on your specific needs.
Comprehensive Drug Guide
How Does Crinone Work?
Crinone contains progesterone, which helps prepare the uterine lining for pregnancy by transforming it into a state that is receptive to a fertilized egg. It also helps maintain early pregnancy by supporting the uterine lining and reducing the risk of miscarriage in women undergoing fertility treatments.
Common Dosages
- Vaginal gel: 4% and 8% concentrations (administered via a single-use applicator).
Typical Dosing
- For progesterone supplementation: The typical dose is 90 mg (8% gel) inserted vaginally once daily, starting after ovulation or the embryo transfer, and continued for up to 10 to 12 weeks of pregnancy.
- For secondary amenorrhea: The usual dose is 45 mg (4% gel) every other day for 6 doses. If no response occurs, the dose may be increased to 90 mg (8% gel) every other day for 6 doses.
Typical Dosing
FDA Approved Indications
- Progesterone supplementation in women undergoing ART.
- Secondary amenorrhea (absence of menstrual periods).
Who Shouldn't Take Crinone?
- Known hypersensitivity to progesterone or any component of the formulation.
- Undiagnosed abnormal genital bleeding.
- Liver disease or hepatic dysfunction.
- Breast cancer or hormone-dependent cancers.
Advice From The Pharmacist
- Administer Crinone using the pre-filled applicator provided. Insert it into the vagina and squeeze the contents out. Avoid intercourse or douching immediately after application.
- Store Crinone at room temperature and protect it from heat and moisture.
- If you miss a dose, take it as soon as you remember, but do not double up doses.
Side Effects of Crinone
Common Side Effects
- Mild cramping
- Breast tenderness
- Headache
- Vaginal irritation or discharge
Uncommon/Severe Side Effects
- Blood clots (deep vein thrombosis, pulmonary embolism)
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Depression or mood changes
Risks and Warnings of Crinone
- Cardiovascular Risk: Progesterone therapy may increase the risk of blood clots, particularly in women with underlying cardiovascular risk factors or a history of clotting disorders.
- Cancer Risk: Prolonged use of progesterone may increase the risk of breast cancer in some women. Discuss your risk factors with your healthcare provider.
- Depression: Progesterone may cause mood swings or exacerbate depression. If you experience significant mood changes, consult your healthcare provider.
Interactions with Crinone
Common Drug Interactions
- CYP450 enzyme inducers: Drugs like rifampin, carbamazepine, and phenobarbital may reduce the effectiveness of Crinone by increasing its metabolism.
- Anticoagulants: Progesterone may increase the risk of blood clots, so using it with blood thinners like warfarin requires careful monitoring.
- Other hormone therapies: Combining Crinone with estrogen or other hormone therapies may increase the risk of side effects.
Alternatives to Crinone
- Endometrin (progesterone vaginal insert): A vaginal insert used for progesterone supplementation during assisted reproductive technology treatments.
- Prometrium (oral progesterone capsules): An oral form of progesterone used for similar purposes, including hormone replacement therapy.
- Progesterone in oil: A progesterone injection commonly used in fertility treatments to support early pregnancy.
